| Project/Area Number |
17K16445
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Hiroshima University |
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Principal Investigator |
Sakane Hiroaki 広島大学, 病院(医), 医科診療医 (60781672)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 低線量CT / DNA損傷 / 染色体異常 / 放射線被ばく / 被ばく / 放射線 |
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| Outline of Final Research Achievements |
Although annual lung cancer screening using low-dose chest computed tomography (LDCT) could reduce the number of deaths in high-risk patients, their biological effects due to radiation exposure remain unclear. To compare LDCT and standard-dose CT (SDCT) for DNA double-strand breaks (DSBs) and chromosome aberrations (CAs) in peripheral blood lymphocytes, we obtained blood samples from about 200 participants before and after CT. DSBs and CAs increased after a SDCT scan, whereas there was no difference in the number of DNA damages observed before and after a LDCT scan.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、肺がん検診で用いられている低線量CT検査の染色体DNAへの影響が現在検査可能なレベルでは検出できないほどに小さいことを示した初めての研究である。放射線学的および生物学的な観点の両方から胸部CT撮影の線量低減の目標は1.5mSvあたりに設定することが可能であると考えられ、今後のより安全な医療放射線被ばくの管理体制の確立とともに、低線量CT検診の普及に伴う肺がん死亡率減少につながることが期待される。
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