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Development of novel biomarkers in colorectal cancer treatment using chemokines

Research Project

Project/Area Number 17K16540
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionKyoto University

Principal Investigator

Inamoto Susumu  京都大学, 医学研究科, 助教 (60794683)

Research Collaborator Kawada Kenji  
Ogawa Ryotaro  
Yamamoto Takamasa  
Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsケモカイン / 大腸癌 / 腫瘍関連好中球 / バイオマーカー
Outline of Final Research Achievements

Using SMAD4 knockdown colorectal cancer metastasis model, we confirmed that the in the SMAD4 knockdown group, elevated expression of the cheekine CXCL1 and CXCL8 accumulated CXCR2 positive neutrophils around colorectal cancer tumor.
In addition, we verified the same phenomenon in human primary colorectal cancer specimens. Furthermore, the tumor infiltrating neutrophils themselves also highly expressed CXCL1 and CXCL8. Examination of patient blood samples showed that the CXCL8 high concentration group had a poor prognosis, suggesting the possibility of a novel biomarker. We finally, summarized these data and submitted it to “Clinical Cancer Research”.

Academic Significance and Societal Importance of the Research Achievements

本研究は腫瘍免疫に焦点を当てている。元来の抗がん剤ではなく、自己の免疫細胞が腫瘍からのケモカインシグナルにより、腫瘍促進を手伝う存在に陥っている。逆にこの点を注目し、新規バイオマーカーとして、癌の早期発見や再発確認に有用であるだけでなく、PD1などと強調して、抗腫瘍薬の開発にも繋げることが可能と考える。さらなる研究を進め、より多くの癌患者の助けになると期待している。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (1 results)

All 2019

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Loss of SMAD4 Promotes Colorectal Cancer Progression by Recruiting Tumor-Associated Neutrophils via the CXCL1/8-CXCR2 Axis.2019

    • Author(s)
      Ogawa R, Yamamoto T, Hirai H, Hanada K, Kiyasu Y, Nishikawa G, Mizuno R, Inamoto S, Itatani Y, Sakai Y, Kawada K.
    • Journal Title

      Clinical Cancer Research

      Volume: - Issue: 9 Pages: 2887-2899

    • DOI

      10.1158/1078-0432.ccr-18-3684

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2017-04-28   Modified: 2020-03-30  

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