| Project/Area Number |
17K16578
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Kitasato University |
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Principal Investigator |
Fukuyama Takashi 北里大学, 北里大学メディカルセンター, 上級研究員 (10462251)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 癌/精巣抗原 / 生殖細胞成熟過程 / 悪性形質獲得 / 胃癌 / 始原生殖細胞 / Helicobacter pylori / 癌 / がん / ステージング / 発がん因子 / 癌/精巣高原 |
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| Outline of Final Research Achievements |
In gametogenesis, it is known that cancer / testis antigens have consistent expression patterns at each stage. On the other hand, cancer / testis antigens are known to be expressed even when malignant traits are acquired (carcinogenesis). We hypothesized that the pattern of cancer / testis antigen expression might have regularity not only in the germ cell maturation process but also in carcinogenesis.
In the present study, we analyzed the expression of cancer / testis antigens by increasing malignant traits in mice and verified the hypothesis. Furthermore, Kita-kyushu lung cancer antigen-1 was identified as a cancer / testis antigen expressed in human gastric cancer in the early stage of canceration, and its expression was proved to be related to H. pylori.
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| Academic Significance and Societal Importance of the Research Achievements |
ゲノム不安定性を有する生殖細胞の成熟過程と発癌過程において、癌/精巣抗原が発現するという共通点があり、本研究により、それらの過程における発現パターンは逆相関を呈することが明らかとなった。各臨床癌の癌/精巣抗原の発現パターンを生殖細胞成熟過程のそれと照らし合わせることにより、その臨床癌がどのステージの癌細胞であるかを層別化できる可能性を示すことができた。癌/精巣抗原による層別化は、効果的な治療方法の選定に有用であると考えられる。
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