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Creation of in vivo dormant human lung adenocarcinoma model

Research Project

Project/Area Number 17K16615
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Respiratory surgery
Research InstitutionJichi Medical University

Principal Investigator

Shibano Tomoki  自治医科大学, 医学部, 助教 (10648900)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords肺癌 / 転移 / 微小環境 / 医療・福祉
Outline of Final Research Achievements

Since prognosis of lung cancer has improved in the past few decades, the opportunity to encounter late recurrence has also increased. Dormancy, a phenomenon that cancers achieve resistant to treatment and sleeps inside the body for few years had been frequently discussed in cancers with slow progression; ie. breast cancers or prostatic cancers, but not for lung cancers. In this study, we discovered that some human adenocarcinoma cell lines express dormant characteristics in vivo and in vitro, suggesting dormancy may also exists in lung cancers.

Academic Significance and Societal Importance of the Research Achievements

肺癌のdormancyに関する研究は今後の肺がん患者の予後改善のためには必要不可欠であるが、進行の早い肺癌では適切なdormancyモデルは存在しない。本研究により得られたヒト肺癌細胞dormancyモデルを今後さらに解析し、確立することで肺がん研究のさらなる発展に繋がると考えている。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (3 results)

All 2018 2017

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Establishment of highly metastatic KRAS mutant lung cancer cell sublines in long-term three-dimensional low attachment cultures.2017

    • Author(s)
      Nakano T, Kanai Y, Amano Y, Yoshimoto T, Matsubara D, Shibano T, Tamura T, Oguni S, Katashiba S, Ito T, Murakami Y, Fukayama M, Murakami T, Endo S, Niki T.
    • Journal Title

      Plos One

      Volume: 12 Issue: 8 Pages: e0181342-e0181342

    • DOI

      10.1371/journal.pone.0181342

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Long-term, 3-dimentional spheroid culture: a putative model to study evolution of detached cancer cells in tumor metastasis.2018

    • Author(s)
      Tomoki Shibano
    • Organizer
      Metastasis Research Society 17th Biennal Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 低接着培養下における肺癌細胞のシグナル伝達と細胞周期制御分子の解析2017

    • Author(s)
      柴野 智毅
    • Organizer
      第26回日本がん転移学会学術集会・総会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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