| Project/Area Number |
17K16648
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 膠芽腫 / グルタミン / セリン / 代謝リモデリング / glioma / アミノ酸代謝 / metabolism / remodeling / amino acid |
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| Outline of Final Research Achievements |
Core of the glioblastoma (GBM) tissue had nutrient starvation. As compared with edge of the GBM, core of the GBM had low concentration of glutamine and high concentration of serine, which was brought by a metabolic remodeling of amino acid. Serine metabolic enzyme, PSAT1, SHMT2, and MTHFD2 were increased in GBM tissues, especially, in the area nearby necrotic regions. Cell proliferation and cell cycle was inhibited by knockdown of PSAT1. In addition, knockdown of PSAT1 induced apoptosis in glioma cells. Our study suggested that the amino acid metabolic remodeling pathway and remodeling enzymes may be useful therapeutic targets in GBM therapy.
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| Academic Significance and Societal Importance of the Research Achievements |
近年、質量分析器などの機器の向上で、がん細胞での代謝リモデリングが細かなことまで明らかとなってきている。しかし、セリンに注目した研究はまだ端緒についたばかりである。膠芽腫におけるセリン代謝が明らかとなれば、新たな治療法の開発につながる可能性もあり、臨床的にも意義ある研究と思われる。
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