Analysis of human synovial mesenchymal stem cell in rheumatoid arthritis patients
| Project/Area Number |
17K16676
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
OTABE Koji 東京医科歯科大学, 統合研究機構, 助教 (70737288)
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| Co-Investigator(Renkei-kenkyūsha) |
SEKIYA Ichiro 東京医科歯科大学, 統合研究機構, 教授 (10345291)
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 再生医療 / 滑膜幹細胞 / 増殖能 / 分化能 / 関節リウマチ / 増殖 / 変形性膝関節症 |
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| Outline of Final Research Achievements |
Synovial mesenchymal stem cells from rheumatoid arthritis patients osteoarthritis patients had similar proliferation property, colony formation property, differentiation capacity, and surface antigen profiles. In suspended synovial tissue culture model, synovial mesenchymal stem cells from rheumatoid arthritis patients and osteoarthritis patients had similar average cell yield, cartilage differentiation property and surface antigen profile, though the cell yield variation was larger among rheumatoid arthritis than osteoarthritis. Both results were reviewed and accepted in the international scientific journal.
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| Academic Significance and Societal Importance of the Research Achievements |
変形性膝関節症および関節リウマチ症例の滑膜幹細胞の増殖能・分化能の違いを明らかにすることが、関節リウマチにおける滑膜炎による関節破壊の病態生理の解明や滑膜幹細胞による再生医療の安全性と治療効果を増幅させる手法の開発に有用である。また関節リウマチ患者に滑膜幹細胞治療を応用する道を開くだけでなく、既存の対象患者に対する移植医療においても培養滑膜幹細胞の品質評価や細胞収量および分化能・移植後の拒絶・炎症反応等、安全性の問題の解決につながる。さらに、幹細胞の増殖・分化を促すサイトカインの解明は、炎症時の滑膜間葉系幹細胞の挙動解明の助力となり、さらには関節内組織損傷における自然治癒過程の解明にも役立つ。
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Report
(3 results)
Research Products
(3 results)
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[Journal Article] Yields and chondrogenic potential of primary synovial mesenchymal stem cells are comparable between rheumatoid arthritis and osteoarthritis patients.2017
Author(s)
Yuji Kohno, Mitsuru Mizuno, Nobutake Ozeki, Hisako Katano, Keiichiro Komori, Shizuka Fujii, Koji Otabe, Masafumi Horie, Hideyuki Koga, Kunikazu Tsuji, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa, Takeshi Muneta, Ichiro Sekiya
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Journal Title
Stem Cell Res Ther
Volume: 8
Issue: 1
Pages: 115-115
DOI
Related Report
Peer Reviewed / Open Access
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