Biological function of LSR in ovarian cancer

• Project/Area Number: 17K16882
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Kochi University
• Principal Investigator: HIRAMATSU Kosuke 高知大学, 医学部附属病院, 特任助教 (10650591)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 卵巣癌 / 脂質代謝 / LSR

Outline of Final Research Achievements

LSR is a membrane protein which takes in lipid molecules. When we administrated some fatty acids to LSR-positive ovarian cancer cell, Elaidic acid which is a one of the trans-fatty acid promoted accumulation of lipid droplets and promoted ATP production and cell proliferation. Moreover, Elaidic acid promoted cell migration of LSR-positive cells. These resuts suggest that LSR contributes ovarian cancer spread. Finally our newly developed anti-LSR antibody inhibited theses processes.

Academic Significance and Societal Importance of the Research Achievements

今回LSRが脂肪酸の一種であるトランス脂肪酸を取り込み癌細胞の増殖と遊走に貢献することを証明した。また抗LSR抗体が卵巣癌の進展に重要な要素である増殖と遊走を阻害することから、抗LSR抗体は新規の卵巣癌治療薬として可能性を示した。

Research Products

• [Journal Article] LSR Antibody Therapy Inhibits Ovarian Epithelial Tumor Growth by Inhibiting Lipid Uptake (2018)
  • Author(s): Hiramatsu K, Serada S, Enomoto T, Takahashi Y, Nakagawa S, Nojima S, Morimoto A, Matsuzaki S, Yokoyama T, Takahashi T, Fujimoto M, Takemori H, Ueda Y, Yoshino K, Morii E, Kimura T, Naka T.
  • Journal Title: Cancer Research Volume: 78 Pages: 516-527
  • Peer Reviewed / Open Access
• [Presentation] LSR promotes lipid metabolism via beta oxidation and contributes cell viability in epithelial ovarian cancer (2018)
  • Author(s): Kosuke Hiramatsu, Satoshi Serada, Minoru Fujimoto, Shinya Matsuzaki, Yutaka Ueda, Kiyoshi Yoshino, Tadashi Kimura, Tetsuji Naka
  • Organizer: AACR annual meeting 2018
  • Int'l Joint Research
• [Presentation] LSR promotes lipid metabolism and contributes cell viability in low glucose environment in epithelial ovarian cancer (2018)
  • Author(s): Kosuke Hiramatsu, Satoshi Serada, Minoru Fujimoto, Shinya Matsuzaki, Yutaka Ueda, Tadashi Kimura, Tetsuji Naka
  • Organizer: IGCS 2018
  • Int'l Joint Research
• [Presentation] 卵巣癌細胞膜発現タンパク質であるLSRを標的とした新規抗体治療法の開発とその機能解析 (2018)
  • Author(s): 平松宏祐
  • Organizer: 第6回婦人科バイオマーカー研究会
• [Presentation] LSR promotes ovarian cancer cell growth following the activation of β-oxidation and its antibody inhibits lipid catabolism (2017)
  • Author(s): Kosuke Hiramatsu, Satoshi Serada, Takayuki Enomoto, Takuhei Yokoyama, Yusuke Takahashi, Minoru Fujimoto, Kiyoshi Yoshino, Tadashi Kimura, Tetsuji Naka
  • Organizer: AACR annual meeting 2017
  • Int'l Joint Research
• [Presentation] LSR promotes beta-oxidation via lipid uptake and subsequent tumor growth in ovarian cancer (2017)
  • Author(s): Kosuke Hiramatsu, Satoshi Serada, Minoru Fujimoto, Shinya Matsuzaki, Yutaka Ueda, Kiyoshi Yoshino, Tadashi Kimura, Tetsuji Naka
  • Organizer: 第76回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] LSR promotes lipid uptake, beta-oxidation and subsequent tumor growth in ovarian cancer (2017)
  • Author(s): Kosuke Hiramatsu, Satoshi Serada, Minoru Fujimoto, Shinya Matsuzaki, Yutaka Ueda, Kiyoshi Yoshino, Tadashi Kimura, Tetsuji Naka
  • Organizer: ESGO 2017
  • Int'l Joint Research