| Project/Area Number |
17K16914
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Osaka University |
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Principal Investigator |
Ito Rie 大阪大学, 医学部附属病院, 医員 (10778616)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 甲状腺未分化癌 / マクロファージ / 遺伝子解析 / RNAシーケンス / 甲状腺癌 |
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| Outline of Final Research Achievements |
Anaplastic thyroid carcinoma is rare, but it is highly malignant and has a poor prognosis. However, it is not known why the malignancy is high because the number of cases is small and the research has not progressed much. In order to clarify this, we focused on the presence of many macrophages in anaplastic thyroid carcinoma, and examined whether the presence of macrophages is associated with malignancy. There were many cases in which macrophages were present in anaplastic thyroid carcinoma, but there were some cases in which macrophages were present even in papillary thyroid carcinoma with good prognosis. Gene expression in anaplastic and other thyroid cancers was also analyzed by RNA-sequence using thyroid cancer cell lines, but there were no features by histological type.
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| Academic Significance and Societal Importance of the Research Achievements |
甲状腺未分化癌のマクロファージに関する報告はいくつかあったがあまり多くはなく日本の症例を使って甲状腺癌のマクロファージを確認したことに意義はあったと考える。しかし、自験例では未分化癌全てでマクロファージが多く存在したわけではなく乳頭癌など他の癌でも存在していたことから悪性度との関係は不明である。また甲状腺癌の細胞株を用いた遺伝子解析の報告はなかったため細胞株8種類を使いRNAシーケンスを行ったが、組織型によって遺伝子発現に特徴はみられなかった。つまり細胞株はその癌の特徴を表していないことがわかった。今後細胞株を使わない実験方法を検討することができるため意義のある実験であった。
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