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Impact on the hearing by lack of mitochondrial tRNA modifier

Research Project

Project/Area Number 17K16927
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionKumamoto University

Principal Investigator

Ogawa Shintaro  熊本大学, 病院, 非常勤診療医師 (10785190)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords加齢性難聴 / tRNA修飾異常 / ミトコンドリア / ミトコンドリア機能異常 / メタボローム解析 / cdk5rap1 / tRNA / 基礎医学 / 聴覚機能
Outline of Final Research Achievements

Auditory function and morphology of the inner ear were investigated at the stage of 1, 3, 5 and 12 months in cdk5rap1 deficient mice.
Age-related hearing loss was progressed in cdk5rap1 deficient mice earlier than in control mice. Hair cell loss and spiral ganglion cell loss were not the same timing each other.

Academic Significance and Societal Importance of the Research Achievements

加齢性難聴の原因の1つとなる事象は、tRNA修飾異常であることがわかった。このことを通して、加齢性難聴発症予防に関する薬剤開発の一助となることが予想される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (2 results)

All 2018 2017

All Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] メタボローム解析を用いたミトコンドリア機能異常による加齢性難聴の原因解明2018

    • Author(s)
      三輪 徹
    • Organizer
      日本耳科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Deficiency of mitochondrial tRNA modification causes progressive hearing loss2017

    • Author(s)
      Toru Miwa
    • Organizer
      53rd Inner ear biology 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2021-02-19  

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