Impact on the hearing by lack of mitochondrial tRNA modifier

Research Project

Project/Area Number	17K16927
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Otorhinolaryngology
Research Institution	Kumamoto University
Principal Investigator	Ogawa Shintaro 熊本大学, 病院, 非常勤診療医師 (10785190)
Project Period (FY)	2017-04-01 – 2020-03-31
Project Status	Completed (Fiscal Year 2019)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords	加齢性難聴 / tRNA修飾異常 / ミトコンドリア / ミトコンドリア機能異常 / メタボローム解析 / cdk5rap1 / tRNA / 基礎医学 / 聴覚機能
Outline of Final Research Achievements	Auditory function and morphology of the inner ear were investigated at the stage of 1, 3, 5 and 12 months in cdk5rap1 deficient mice. Age-related hearing loss was progressed in cdk5rap1 deficient mice earlier than in control mice. Hair cell loss and spiral ganglion cell loss were not the same timing each other.
Academic Significance and Societal Importance of the Research Achievements	加齢性難聴の原因の1つとなる事象は、tRNA修飾異常であることがわかった。このことを通して、加齢性難聴発症予防に関する薬剤開発の一助となることが予想される。