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Oxidative Stress and Advanced Glycation End Products in the Diabetic Retinopathy

Research Project

Project/Area Number 17K16962
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionShinshu University

Principal Investigator

Toriyama Yuichi  信州大学, 学術研究院医学系, 助教 (90757759)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords糖尿病網膜症 / 酸化ストレス / 終末糖化産物 / 最終糖化産物 / 糖尿病 / タンパク質 / ストレス
Outline of Final Research Achievements

Both the Lens-FR and aqueous ORP showed significantly higher in the diabetic group than in the non diabetic group. Both the lens-FR and aqueous ORP were significantly correlated with the severity of diabetic retinopathy. There was no significant correlation between the lens FR and the aqueous ORP.
There was a strong correlation between the concentration of aqueous VEGF and the severity of diabetic retinopathy. Although the strong correlation was found between the aqueous ORP and the concentration of VEGF, there was no significant correlation between the Lens-FR and aqueous VEGF.
In conclusion, we could evaluate in vivo accumulation of AGE and intraocular oxidative stress with minimally invasion. Lens FR and aqueous ORP may serve as new independent indicators for the evaluation of diabetes duration and the severity of diabetic retinopathy.

Academic Significance and Societal Importance of the Research Achievements

糖尿病網膜症の発症に終末糖化産物の蓄積と酸化ストレスは重要な要因となる。本研究は終末糖化産物蓄積を反映する水晶体自発蛍光値を非侵襲的な方法で測定し、眼内の酸化ストレス状況を反映する前房水酸化還元電位を低侵襲かつ短時間で測定した。いずれも糖尿病網膜症の発症と進行に従って上昇し、水晶体自発蛍光値は糖尿病の罹病期間の推測に、酸化還元電位は糖尿病網膜症の活動性にそれぞれ有用な指標となる可能性が示された。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (3 results)

All 2019 2018

All Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Intraocular Oxidative Stress and Accumulation of Advanced Glycation End Products in Diabetic Eyes2019

    • Author(s)
      Yuichi Toriyama
    • Organizer
      The 34th Asia-Pacific Åcademy of Ophthalmology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 眼内酸化ストレスおよび水晶体自発蛍光値と糖尿病網膜症との関連についての検討2019

    • Author(s)
      鳥山 佑一
    • Organizer
      第123回日本眼科学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 糖尿病黄斑浮腫における前房水サイトカイン濃度と抗VEGF注射回数との関連の検討2018

    • Author(s)
      鳥山 佑一
    • Organizer
      第122回日本眼科学会総会
    • Related Report
      2018 Annual Research Report

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Published: 2017-04-28   Modified: 2020-03-30  

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