Widespread injury of intestinal serosa with type I collagenase promote colonization of transplanted enteric neural stem cells
Project/Area Number |
17K17008
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Pediatric surgery
|
Research Institution | Kanazawa Medical University |
Principal Investigator |
|
Project Period (FY) |
2017-04-01 – 2020-03-31
|
Project Status |
Completed (Fiscal Year 2019)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 細胞外マトリクス / 腸管神経細胞 / 腸管神経堤由来細胞 / 細胞外マトリックス / 発生・分化 |
Outline of Final Research Achievements |
Hirschsprung’s disease (HSCR) causes abdominal distension and survival requires surgical excision of aganglionic bowel. However, after surgery, enterocolitis and fecal incontinence commonly occurs. Therefore, New strategies are needed to enhance bowel colonization by enteric neuron precursors and to reduce HSCR occurrence. In this study we demonstrated that injury of serosa with type I collagenase promote colonization of transplanted enteric neural crest derived Cells.
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Academic Significance and Societal Importance of the Research Achievements |
我々の研究結果は、I型コラゲナーゼを処理したレシピエントの大腸が、未治療の大腸よりも腸管神経系をより迅速に展開したことを示した。ドナーの神経幹細胞を受容可能な結腸にするこれらの発見は、細胞療法の現在の戦略を前進させることに役立つ。
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Report
(4 results)
Research Products
(5 results)