Investigation of the improvement of breast skin after radiation with fat grafting
| Project/Area Number |
17K17024
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
MUTO Mayu 横浜市立大学, 医学研究科, 共同研究員 (10723348)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 乳房再建 / 脂肪注入 / 放射線照射後 / 脂肪移植 / 放射線 |
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| Outline of Final Research Achievements |
Five patients (cultured adipose stem cell-added fat grafting: 4, pure fat grafting: 1) were included in the study. At present, the number of surgeries was 3 in 2 cases, 2 in 2 cases, and 1 in 1 case. 2 cases of reconstruction were completed, 2 cases were expected to be completed, and 1 case was in the middle of treatment.The results of viscoelasticity measurements showed that in all but one of the four cases, fat grafting tended to increase the tension and elasticity of the post-irradiation skin and reduce the skin fatigue effect. As for the volume measurement, an increase of 51.8 cc was observed in only one completed case.However, fat grafting was also performed on the concave area after biopsy on the healthy side, and although the breast shape was clearly improved visually, the volume decreased by -8.8 cc, so there was an error in the measurement equipment, and the possibility of a larger volume increase was considered.
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| Academic Significance and Societal Importance of the Research Achievements |
放射線照射後の皮膚は、晩期障害として微小血管の閉塞や過剰な線維化が起こることにより、乳房皮膚が硬く乾燥し、創傷治癒機序が正常に働かない状態となっている。本研究では、培養脂肪幹細胞付加脂肪または純脂肪による脂肪注入により、放射線照射後の皮膚の張りは増し、弾力性は増し、皮膚疲労効果は小さくなる傾向にあった。乳癌術後・放射線照射後の症例に対する脂肪注入による乳房再建は、乳房体積を増しつつ、乳房皮膚の状態が改善する可能性が示唆された。
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Report
(5 results)
Research Products
(27 results)
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[Presentation] 腹部以外を採取部とする自家組織乳房再建【対称性の獲得を目的とした皮弁選択・乳房マウンド作成・修正術】2017
Author(s)
武藤真由, 佐武利彦, 佐治詩保子, 本間有貴, 芳賀祥子, 長谷川佳子, 青木宏信, 前川二郎
Organizer
第60回日本形成外科学会総会・学術集会, 大阪,2017,4. シンポジウム
Related Report
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