| Project/Area Number |
17K17042
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
|
| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
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| Keywords | 体外循環 / 血液濾過透析 / 人工肺 / 呼吸不全 / 重症呼吸不全 / 酸塩基平衡 / ECCO2R |
|---|
| Outline of Final Research Achievements |
We developed an extracorporeal lung and renal assist device (ELRAD), comprising acid infusion, membrane lung, continuous hemodiafiltration and alkaline infusion. To evaluate this system, we conducted in vivo studies using experimental swine which were connected to the new system. As a result, a developed CO2 removal system efficiently removed CO2 at low blood flow and reduced minute ventilation, while maintaining acid-base balance within the normal range.
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| Academic Significance and Societal Importance of the Research Achievements |
重症急性呼吸不全患者では血中二酸化炭素濃度を適正域に保つために高い人工呼吸器圧を要するが，これがかえって人工呼吸器関連肺障害を引き起こす．新規システムは酸塩基平衡を用いることで二酸化炭素を除去するものであり，生体豚の実験でその有用性が示されたことは学術的意義があり，さらに安全かつ効率的に二酸化炭素を除去し，同時に腎機能を補助することで重症呼吸不全患者の肺保護戦略を非侵襲的に行うことができると考えられ，社会的意義がある研究成果である．
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