| Project/Area Number |
17K17046
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 敗血症 / サイトカイン / 血液浄化 / 敗血症モデル / 血液浄化療法 / 集中治療 / 集中治療医学 |
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| Outline of Final Research Achievements |
It is widely believed that the pathogenesis of sepsis is caused by organ damage due to excessive inflammatory cytokines and immunodeficiency due to excessive anti-inflammatory cytokines. We hypothesized that blood purification would modulate the excessive cytokines and balance the cytokines, which would be useful for treatment. In this study, we were able to create a rat sepsis model in which the septic state persisted for several days. Several cytokine changes were identified by us for each period of illness. Histologically, organ damage was confirmed by maintaining the septic state, and we considered this model to be unprecedented in its reproducibility of long-term sepsis. As a next step, we plan to use this model to test the therapeutic effect of correcting cytokine balance by blood purification therapy.
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| Academic Significance and Societal Importance of the Research Achievements |
敗血症は現在医学でも致死率の高い疾患であるが，抗菌薬投与や感染巣のデブリードマン以外には根本的な治療がなく，治療の主体は全身管理である．過剰な炎症により臓器障害が引き起こされることに対し，炎症を強力に抑制する戦略がこれまで試みられたが臨床応用された治療法はない．感染に抵抗できる免疫力残しつつ臓器障害をきたさないサイトカインのバランスを保つという戦略が新たな敗血症治療になりうると考えている．今回構築した新たな敗血症動物モデルは長期の罹患期間に応じたサイトカインプロファイルを明らかにし，敗血症を原因とした臓器障害を再現するモデルである．敗血症の病態に基づく治療戦略開発の第一歩であると考える．
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