| Project/Area Number |
17K17080
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Research Collaborator |
ICHIKAWA hiroyuki
SATO tadasu
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 歯髄 / 神経ペプチド / イオンチャネル |
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| Outline of Final Research Achievements |
In the tooth pulp, many neuropeptides or ion channels are present, and thought to act as neurotransmitters or sensors to various stimuli. This study demonstrates the role of these components in endodontic disease. PACAP is one member of the neuropeptide family, and localized in the tooth pulp. After pulp exposure, inflammatory cells were scattered throughout the coronal to root pulp. At 28 days after pulp exposure, these cells are also detected in the periapical region. By immunohistochemical staining, PACAP-immunoreactive (IR) nerve fibers increased in the tooth pulp after pulp exposure. These fibers may suppress the neurological inflammation caused by CGRP. In the central nerves system, PACAP-IR nerve fibers and its receptors detected in the brainstem. This result suggests that PACAP suppress pain transmission and/or inflammation in the tooth pulp.
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| Academic Significance and Societal Importance of the Research Achievements |
歯髄疾患は痛みを伴うことが多く、時には歯の喪失の一因となる。この病態に対して、痛み感覚やその抑制に関わる神経ペプチドやイオンチャネルのうち、PACAPが神経原性炎症や痛み感覚を抑制している可能性を示唆した。このことはこれまでに知られていなかった、学術的意義の大きな成果である。今後は病態の把握だけでなく、PACAPを用いた疾患の治癒方法の探索へと発展が期待できるため、社会的意義も大きいと考える。
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