| Project/Area Number |
17K17242
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 神経障害性疼痛 / ドーパミン神経 / ドーパミン受容体 / von Frey filament / c-Fos / 神経科学 / 歯学 / 薬理学 |
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| Outline of Final Research Achievements |
We examined a hypothesis that dopaminergic nervous system is involved in alleviation of neuropathic pain in the orofacial region. Neuropathic model rats were made by chronic constriction injury of infraorbital nerve (ION-CCI). ION-CCI rats showed mechanical hypersensitivity (allodynia). Dopamine D2 receptor agonist attenuated mechanical hypersensitivity induced by ION-CCI. And dopamine D2 receptor antagonist enhanced mechanical hypersensitivity. These results suggested that dopaminergic nervous system is involved in change in symptom of neuropathic pain in the orofacial region, and dopamine D2 receptor agonist in particular is associated with alleviation of neuropathic pain.
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| Academic Significance and Societal Importance of the Research Achievements |
ドーパミン神経系と神経障害性疼痛の関係について調べた研究は少なく、不明な点が多い。本研究は口腔領域の侵害性疼痛モデルラットを用いて、その一端を明らかにすることができた。特に、ドーパミンD2受容体作動薬がその症状を緩和することが示唆された点の意義が大きいと考える。生活の質（quality of life：QOL)が大きく損なわれている神経障害性疼痛患者の症状の緩和に関する研究に、基礎的なデータを提供することができた。
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