Involvement of PD-L1/PD-1 signal in invasion and metastasis of oral squamous cell carcinoma
| Project/Area Number |
17K17264
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 口腔扁平上皮癌 / PD-1 / 免疫チェックポイント分子 / program cell death 1 / MMP-3 / 抗免疫チェックポイント分子抗体療法 / PD-L1 / 口腔扁平上皮癌 (OSCC) / 転移 |
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| Outline of Final Research Achievements |
Using OSCC biopsy tissue samples, we show that PD-L1 / PD-1 signals cause immunosuppression and are involved in infiltration and metastasis. We have also shown that PD-L1 / PD-1 co-expression in biopsy tissue samples reduce patient's over-all survival rates. In addition, as a result of binding recombinant human PD-1 to PD-L1 overexpressing cell lines (SAS cells), signal transduction from PD-1 to PD-L1 promotes OSCC proliferation, migration, and infiltration.
In this study, it was suggested that PD-1 may act on PD-L1 to activate TNF Signaling Pathway in OSCC cells and promote migration and infiltration.
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| Academic Significance and Societal Importance of the Research Achievements |
これまで、PD-1/PD-L1に関してはその腫瘍免疫学的側面にのみ、フォーカスが当てられていた。しかしながら、本研究結果より、PD-1はOSCCに発現しているPD-L1に作用することで、OSCC細胞中のTNF Signaling Pathwayを活性化することが明らかとなった。これにより、OSCCの遊走及び浸潤を亢進することでOSCCの悪性化に寄与している可能性が示唆された。
このことは、抗PD-1抗体の治療効果予測に際して、活用できる可能性を含んでおり、更なる解析が必要であると考える。
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Report
(5 results)
Research Products
(6 results)
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[Journal Article] Significant association of increased PD-L1 and PD-1 expression with nodal metastasis and a poor prognosis in oral squamous cell carcinoma.2018
Author(s)
Maruse Y, Kawano S, Jinno T, Matsubara R, Goto Y, Kaneko N, Sakamoto T, Hashiguchi Y, Moriyama M, Toyoshima T, Kitamura R, Tanaka H, Oobu K, Kiyoshima T, Nakamura S.
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Journal Title
International Journal of Oral and Maxillofacial Surgery
Volume: －
Issue: 7
Pages: 836-845
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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