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Study of the effect on osteoclastogenesis and orthodontic tooth movement by osteocyte stimulation by TNF

Research Project

Project/Area Number 17K17309
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontics/Pediatric dentistry
Research InstitutionTohoku University

Principal Investigator

Sugisawa Haruki  東北大学, 歯学研究科, 大学院非常勤講師 (20792162)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords骨細胞 / 破骨細胞 / TNF-α / 骨免疫学
Outline of Final Research Achievements

It has been reported that TNF-α is expressed and involved in osteoclasts and bone formation in orthodontic tooth movement. It was newly found that osteocytes express RANKL and induce osteoclast formation in physiological bone resorption. Therefore, the purpose of this study is to investigate the influence of TNF-α on osteocytes and how osteoclast formation in inflammatory site is affected in vitro and in vivo and to elucidate the mechanism. In the present study, it was found that when TNF-α acts on osteocyte, the expression of RANKL is increased. Furthermore, it was found that the action of TNF-αincreases the expression of RANKL in osteocyte in vivo.

Academic Significance and Societal Importance of the Research Achievements

本研究では骨細胞もTNF-αが作用するとRANKLを発現し、破骨細胞形成を促進するように働くことがin vitroおよびin vivoで確認された。本研究で、様々な炎症性骨疾患に関与する炎症性サイトカインであるTNF-αの骨細胞への影響を解明することは、骨細胞を炎症性骨疾患の標的細胞の一つとして選択でき、Osteoimmunologyの発展に寄与すると考えられる。また、新しい治療薬、治療法などの医療の発展にもつながり、さらには矯正学的歯の移動のメカニズムの解明にも寄与する可能性のある、非常に意義のあることだと考えている。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (9 results)

All 2018 2017

All Journal Article (4 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] The glucagon-like peptide-1 receptor agonist exendin-4 inhibits lipopolysaccharide-induced osteoclast formation and bone resorption via inhibition of TNF-α expression in macrophages.2018

    • Author(s)
      Wei-Ren Shen, Keisuke Kimura, Masahiko Ishida, Haruki Sugisawa, Akiko Kishikawa, Kazuhiro Shima, Saika Ogawa, Jiawei Qi, Hideki Kitaura
    • Journal Title

      Journal of Immunology Research

      Volume: 2018 Pages: 5783639-5783639

    • DOI

      10.1155/2018/5783639

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Corrosion resistance and mechanical properties of titanium nitride plating on orthodontic wires2018

    • Author(s)
      Sugisawa, H., Kitaura, H., Ueda, K., Kimura, K., Ishida, M., Ochi, Y., Kishikawa, A., Ogawa, S., Takano-Yamamoto T
    • Journal Title

      Dental Materials Journal

      Volume: 37 Issue: 2 Pages: 286-292

    • DOI

      10.4012/dmj.2016-348

    • NAID

      130006588780

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of muramyl dipeptide for lipopolysaccharide-mediated biological activity and osteoclast activity.2018

    • Author(s)
      Kitaura, H., Ishida, M., Kimura, K., Sugisawa, H., Kishikawa A, Shima, K., Ogawa S., Qi J, Kitaura H., Shen WR
    • Journal Title

      Anal. Cell. Pathol.

      Volume: Volume 2018 Pages: 8047610-8047610

    • DOI

      10.1155/2018/8047610

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 歯科矯正用Ni-Tiワイヤーに対する表面コーティングによる耐食性の解析2017

    • Author(s)
      木村桂介,杉澤晴紀,井田裕人,石田匡彦,島和弘,岸川明子,小川紗衣香,北浦英樹
    • Journal Title

      東北矯正歯科学会雑誌

      Volume: 25 Pages: 9-15

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Exendin-4, a GLP-1 receptor agonist, suppresses inflammation-induced osteoclast formation and bone resorption.2017

    • Author(s)
      Shen WR, Kimura K, Ishida M, Sugisawa H, Ochi Y, Kishikawa A, Shima K, Ogawa S., Qi J, Kitaura H.
    • Organizer
      The 12th International Workshop on Biomaterials in Interface Science.
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effects of diabetic medicine exendin-4 for osteoclast formation and bone resorption.2017

    • Author(s)
      Shen WR, Kimura K, Ishida M, Sugisawa H, Ochi Y, Kishikawa A, Shima K, Ogawa S., Qi J, Kitaura H.
    • Organizer
      The 76th Annual Meeting of the Japanese Orthodontic Society.
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 脂肪酸受容体GPR120の破骨細胞形成および骨吸収との関連性の検討2017

    • Author(s)
      木村桂介、石田匡彦、島和弘、杉澤晴紀、越智由美子、岸川明子、小川紗衣香、斉嘉韋、沈威任、北浦英樹
    • Organizer
      第76回日本矯正歯科学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 破骨細胞形成および骨吸収に対する脂肪細胞に発現するケモカインCXCL12の作用の検討2017

    • Author(s)
      島和弘、木村桂介、石田匡彦、杉澤晴紀、越智由美子、岸川明子、小川紗衣香、斉嘉韋、沈威任、北浦英樹
    • Organizer
      第76回日本矯正歯科学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] TiNコーティングを施した歯科矯正用ワイヤーの摩擦力の検討2017

    • Author(s)
      杉澤晴紀、北浦英樹、上田恭介、木村桂介、石田匡彦、越智由美子、岸川明子、小川紗衣香、山本照子
    • Organizer
      第76回日本矯正歯科学会大会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2020-03-30  

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