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Establishment of new wound care for chronic wound with infection by analysing lymphocyte function

Research Project

Project/Area Number 17K17393
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Fundamental nursing
Research InstitutionTohoku University

Principal Investigator

Tanno Hiromasa  東北大学, 医学系研究科, 助教 (10755664)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords創傷治癒 / 感染 / NKT細胞 / リンパ球 / 白血球 / 緑膿菌 / 看護学 / 免疫学
Outline of Final Research Achievements

Chronic wound infections are considered one of the most severe wound problem. Indeed, some studies reported bacteria are present over 90 % of chronic wounds. Pseudomonas aeruginosa is frequently isolated from chronic wounds and thought to be a cause of delayed wound healing. Previously, we showed that iNKT cell deficiency resulted in a delayed wound healing process. Other group showed that NKT cells enhanced pulmonary clearance of this bacteria. However, the role of NKT cells in the host defense to P. aeruginosa infection at the wound sites remains to be elucidated. In this study, we conducted to elucidate the role of NKT cells in the host defense to P. aeruginosa infection at the wound site. NKT cells promote re-epithelialization and P. aeruginosa clearance during wound healing. This mechanism may be associated with increased levels of IL-17A and β-defensin1.

Academic Significance and Societal Importance of the Research Achievements

これまで、リンパ球が創傷治癒促進に関わることは報告されているが、感染および貪食細胞に対する機能は評価されていない。また、感染によるバイオフィルム産生に対する研究は抗菌薬による細菌数減少に主眼が置かれ、リンパ球機能など宿主側の要因については殆ど明らかになっていない。
本研究により、リンパ球の一種NKT細胞が緑膿菌接種創の創傷治癒と菌排除を促進することが明らかとなり、リンパ球機能に着目した新しいケア技術の確立につながる可能性を示した。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (9 results)

All 2019 2018 2017

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (5 results) Book (2 results)

  • [Journal Article] Dectin-2-Mediated Signaling Leads to Delayed Skin Wound Healing through Enhanced Neutrophilic Inflammatory Response and Neutrophil Extracellular Trap Formation.2019

    • Author(s)
      Miura T, Kawakami K, Kanno E, Tanno H, Tada H, Sato N, Masaki A, Yokoyama R, Kawamura K, Kitai Y, Takagi N, Yamaguchi K, Yamaguchi N, Kyo Y, Ishii K, Imai Y, Saijo S, Iwakura Y, Tachi M.
    • Journal Title

      J Invest Dermatol

      Volume: 139(3) Issue: 3 Pages: 702-711

    • DOI

      10.1016/j.jid.2018.10.015

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Invariant NKT cells promote skin wound healing by preventing a prolonged neutrophilic inflammatory response2017

    • Author(s)
      Hiromasa Tanno, Kazuyoshi Kawakami, Emi Kanno, Aiko Suzuki, Naoyuki Takagi, Hideki Yamamoto, Keiko Ishii, Yoshimichi Imai, Ryoko Maruyama, Masahiro Tachi
    • Journal Title

      Wound Repair and Regeneration

      Volume: 25(5) Issue: 5 Pages: 805-815

    • DOI

      10.1111/wrr.12588

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 緑膿菌接種創の治癒過程と菌排除におけるNKT細胞欠損の影響.2018

    • Author(s)
      丹野寛大,菅野恵美, 佐藤すずな, 山口賢次, 石井恵子, 丸山良子, 川上和義, 館正弘
    • Organizer
      第20回日本褥瘡学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 緑膿菌接種創の治癒過程におけるNatural Killer T細胞の役割.2018

    • Author(s)
      丹野寛大,菅野恵美,佐藤すずな,霜野瑞葵,佐々木綾子,山口賢次,石井恵子,丸山良子,川上和義, 館正弘
    • Organizer
      第48回日本創傷治癒学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Contribution of iNKT cells to the clearance of Pseudomonas aeriginosa from skin wounds.2018

    • Author(s)
      Hiromasa Tanno, Emi Kanno, Ayako Sasaki, Keiko Ishii, Kazuyoshi Kawakami
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] NKT細胞は好中球性炎症を制御し皮膚創傷治癒を促進する2017

    • Author(s)
      丹野寛大, 菅野恵美, 三浦孝行, 石井恵子, 中山俊憲, 谷口克, 丸山良子, 館正弘, 川上和義
    • Organizer
      第28回日本生体防御学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 皮膚創傷治癒過程におけるNKT細胞の役割ー好中球性炎症に注目してー2017

    • Author(s)
      丹野寛大, 菅野恵美, 佐藤紀子, 正木愛梨, 三浦孝行, 山口賢次, 石井恵子, 丸山良子, 川上和義, 館 正弘
    • Organizer
      第47回日本創傷治癒学会
    • Related Report
      2017 Research-status Report
  • [Book] WOC Nursing 2018年7月 Vol.6No.7 特集:創傷治癒の最前線2018

    • Author(s)
      丹野寛大、菅野恵美
    • Publisher
      医学出版
    • Related Report
      2018 Annual Research Report
  • [Book] 看護技術2017年8月号 創部感染の予防とケア2017

    • Author(s)
      丹野寛大, 菅野恵美
    • Total Pages
      4
    • Publisher
      メヂカルフレンド社
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2020-03-30  

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