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Analysis of environmental contamination by Helicobacter spp. and it's infection routes to humans in Nara prefecture.

Research Project

Project/Area Number 17K17546
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Community health nursing
Research InstitutionNara Medical University

Principal Investigator

Horiuchi Saori  奈良県立医科大学, 医学部, 助教 (40794334)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
KeywordsHelicobacter pylori / 感染源 / PCR / cagA / 住民 / 動物 / Helicobacter spp. / 感染経路 / LAMP / 小・中学生 / 日常生活環境
Outline of Final Research Achievements

Chronic infection with Helicobacter pylori have been proved to be associated with gastric cancer. We aimed to clarify the prevalence of H. pylori in the community, where gastric cancer incidence is high, for the identification of infection source. We collected 163 samples (90 fecal samples from the residents and 73 environmental samples; water samples used for drinking and daily life, as well as, vegetables which were homegrown for eating in the raw and feces from animals, including pets and wild animals).
H. pylori glmM gene was detected in 20% (18/90) of fecal samples from the residents. The cagA-positive H. pylori strains which considered significantly increased risk of gastric diseases was detected only in 33.3% (5/18) of H. pylori positive fecal samples. Although H. pylori was not detected in environmental samples, contact with living environment especially animals, were suggested as the sources of infection, based on the questionnaire.

Academic Significance and Societal Importance of the Research Achievements

本研究により、胃がんの発生が多い県内の地域住民および生活環境中におけるH. pyloriの蔓延実態が明らかになった。生活環境検体の調査からはH. pyloriの感染源は特定されなかったが、今後は生活環境に加え、人獣共通感染症の視点も含めた更なる疫学調査の必要性が示唆された。地域においてH. pyloriの感染源を包括的に検討している研究は少ないため、本研究をモデルケースとして確立することで、今後の大規模な疫学調査の基盤となる可能性が考えられた。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (4 results)

All 2020 2019 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Development of a loop-mediated isothermal amplification assay for rapid Helicobacter pylori detection.2019

    • Author(s)
      Horiuchi S, Nakano R, Nakano A, Hishiya N, Uno K, Suzuki Y, Tanouchi A, Kakuta N, Masui T, Jojima N, Yano H.
    • Journal Title

      J Microbiol Methods.

      Volume: 163 Pages: 105653-105653

    • DOI

      10.1016/j.mimet.2019.105653

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] 奈良県におけるHelicobacter pyloriの感染源の検討2020

    • Author(s)
      堀内沙央里、中野竜一、中野章代、鈴木由希、角田尚紀、角田梨紗子、城島哲子、矢野寿一
    • Organizer
      第31回日本臨床微生物学会総会・学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 奈良県における住民のHelicobacter pyloriへの感染実態と感染経路の検討2019

    • Author(s)
      堀内沙央里、中野竜一、中野章代、鈴木由希、角田尚紀、矢野寿一
    • Organizer
      第89回日本感染症学会 西日本地方会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Helicobacter pylori検出のためのLAMP 法の開発2018

    • Author(s)
      堀内沙央里、中野竜一、中野章代、城島哲子、矢野寿一
    • Organizer
      第88回日本感染症学会西日本地方会学術集会・第61回日本感染症学会中日本地方会学術集会・第66回日本化学療法学会西日本支部総会
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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