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Analysis of neuro-glial interactions via extracellular ion signals

Research Project

Project/Area Number 17K17615
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Basic / Social brain science
General physiology
Research InstitutionYamagata University

Principal Investigator

Goto Jun-Ichi  山形大学, 医学部, 助教 (70435650)

Project Period (FY) 2017-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsシナプス可塑性 / イノシトール三リン酸 / カルシウムシグナル / ニューロン / ニューロングリア相互作用 / グリア / 生理学 / 神経科学 / 脳・神経 / シグナル伝達 / イオン輸送
Outline of Final Research Achievements

Although preliminary data were obtained from simultaneous measurements of extracellular ion concentrations and synaptic plasticity, it was difficult to record the data with high precision. Thus we changed the original plan and published the related research results.
We examined depotentiation and LTP inhibition of hippocampal synapses in IRBIT KO mice, which are downstream of IP3 receptor signaling, and found that both depotentiation and LTP inhibition were inhibited in IRBIT KO mice, that was the same as in IP3 receptor KO mice. On the other hand, short tetanus LTP, which was enhanced in IP3 receptor KO mice, was not changed in IRBIT KO mice, suggesting that another pathway downstream of the IP3 receptor is involved.

Academic Significance and Societal Importance of the Research Achievements

本研究成果は記憶・学習における神経系の基盤であるシナプス可塑性とカルシウムシグナル及びIP3シグナルがどのように関連するかの一端を明らかにしたものである。カルシウムシグナルが記憶・学習に果たす役割については広範で詳細な研究がなされているが、それに比べるとIP3シグナルの果たす役割についての理解は限定的である。本研究では特にIP3シグナルが従来型のカルシウムシグナルに非依存的にシナプス可塑性を制御していることを明らかにしており、記憶・学習の細胞基盤の多様性について新たな知見を提供するものである。

Report

(8 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (2 results)

All 2022 2019

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Synaptic plasticity in hippocampal CA1 neurons of mice lacking inositol-1,4,5-trisphosphate receptor-binding protein released with IP3 (IRBIT)2022

    • Author(s)
      Goto Jun-Ichi、Fujii Satoshi、Fujiwara Hiroki、Mikoshiba Katsuhiko、Yamazaki Yoshihiko
    • Journal Title

      Learning & Memory

      Volume: 29 Issue: 4 Pages: 110-119

    • DOI

      10.1101/lm.053542.121

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Depotentiation at the hippocampal CA1 synapse depends on the basal synaptic transmission2019

    • Author(s)
      Jun-Ichi Goto, Satoshi Fujii, Kenya Kaneko, Hiroki Fujiwara, Yoshihiko, Yamazaki, Katsuhiko Mikoshiba
    • Organizer
      9th FAOPS (Federation of the Asian and Oceanian Physiological Societies) CONGRESS
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2025-01-30  

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