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Analysis of structure and function of actin bundle in the motile ciliated cells

Research Project

Project/Area Number 17K17701
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Morphology/Structure
Functional biochemistry
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

Shinohara Kyosuke  東京農工大学, 工学(系)研究科(研究院), 特任准教授 (20527387)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords繊毛 / 細胞骨格 / アクチン / 電荷
Outline of Final Research Achievements

In this project, we have examined function of Dpcd protein in the mouse motile ciliated cells. Using mouse molecular genetics and in vitro reconstitutions, we have found that Dpcd organizes actin network that is involved in maturation of the mouse motile cilia. Further, Dpcd is an actin bundling protein in redox-dependent manner.

Academic Significance and Societal Importance of the Research Achievements

本研究課題の成果により劣性の遺伝子性疾患である原発性繊毛運動不全症の発症メカニズムの一端が明らかとなった。まだ根本的な治療法のない疾患への治療戦略を考える上で情報を提供する。また、まだ未解明の事が多い繊毛の生物学、特に細胞骨格と繊毛の関係性を考えていく上で本研究成果は新しい知見をもたらし今後のこの分野の方向性(アクチン骨格と繊毛)に繋がる可能性がある。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (3 results)

All 2020 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Rsph4a is essential for the triplet radial spoke head assembly of the mouse motile cilia2020

    • Author(s)
      Yoke Hiroshi、Ueno Hironori、Narita Akihiro、Sakai Takafumi、Horiuchi Kahoru、Shingyoji Chikako、Hamada Hiroshi、Shinohara Kyosuke
    • Journal Title

      PLOS Genetics

      Volume: 16 Issue: 3 Pages: e1008664-e1008664

    • DOI

      10.1371/journal.pgen.1008664

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Primary Ciliary Dyskinesia protein Dpcd forms barrier that regulates transport between cilia and cytoplasm by electrostatic actin bundling2018

    • Author(s)
      篠原恭介
    • Organizer
      EMBO Workshop Cilia 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 原発性繊毛運動不全症の原因遺伝子Dpcdの機能解析2018

    • Author(s)
      澤田麻里
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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