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New therapy for recurrent glioblastoma, EUrd-CED

Research Project

Project/Area Number 17K17735
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Tumor therapeutics
Research InstitutionNiigata University

Principal Investigator

Tsukamoto Yoshihiro  新潟大学, 医歯学総合病院, 助教 (90648891)

Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsglioma / EUrd / Glioblastoma / temozolomide / 膠芽腫 / TMZ耐性 / glioblastoma / CED / Glioma stem cell
Outline of Final Research Achievements

This study examined the efficacy of Convection enhanced delivery theraphy (CED) with EUrd, a newly identified therapeutic agent, for human-derived tumor cell lines and animal xenograft models resistant to temozolomide. Two temozolomide-resistant brain tumor cell lines were established. Each cell line proved to be sufficiently capable of cell experimentation, and the NGT41 cell line could almost certainly generate brain tumor models in immunocompromised mice. In the future, we plan to proceed with CED treatment experiments using EUrd.

Academic Significance and Societal Importance of the Research Achievements

膠芽腫は集学的な治療が行われる。治療初期は腫瘍の縮小などの効果が見られるが、徐々に治療耐性化することが問題である。本研究ではテモゾロミド耐性細胞への新規治療の研究である。ここまでの期間で、新規治療の研究に不可欠なヒト由来の脳腫瘍細胞株と免疫不全マウスへの移植モデルを確立した。またNGT41という細胞株でのモデルは、実際の患者さんと同様の薬剤を投与し、同様の治療経過を取ることも実証した。このようなマウスモデルは悪性神経膠腫などの悪性脳腫瘍への新規治療薬開発の為に大きな意義があると考えられる。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (3 results)

All 2019 2018

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 3 results)

  • [Journal Article] MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas2019

    • Author(s)
      Hideaki Abe, Manabu Natsumeda1, Masayasu Okada, Jun Watanabe, Yoshihiro Tsukamoto, Yu Kanemaru, Junichi Yoshimura, Makoto Oishi, Rintaro Hashizume, Akiyoshi Kakita and Yukihiko Fujii
    • Journal Title

      Frontiers in Oncology

      Volume: 9 Pages: 1-10

    • DOI

      10.3389/fonc.2019.01568

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dramatic response of BRAF V600E-mutant epithelioid glioblastoma to combination therapy with BRAF and MEK inhibitor: establishment and xenograft of a cell line to predict clinical efficacy2019

    • Author(s)
      Kanemaru Yu、Natsumeda Manabu、Okada Masayasu、Saito Rie、Kobayashi Daiki、Eda Takeyoshi、Watanabe Jun、Saito Shoji、Tsukamoto Yoshihiro、Oishi Makoto、Saito Hirotake、Nagahashi Masayuki、Sasaki Takahiro、Hashizume Rintaro、Aoyama Hidefumi、Wakai Toshifumi、Kakita Akiyoshi、Fujii Yukihiko
    • Journal Title

      Acta Neuropathologica Communications

      Volume: 7 Issue: 1 Pages: 119-119

    • DOI

      10.1186/s40478-019-0774-7

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas2018

    • Author(s)
      Hideaki Abe, Manabu Natsumeda, Yu Kanemaru, Jun Watanabe, Yoshihiro Tsukamoto, Masayasu Okada, Junichi Yoshimura, Makoto Oishi, Yukihiko Fujii
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 58 Issue: 7 Pages: 290-295

    • DOI

      10.2176/nmc.ra.2018-0044

    • NAID

      130007405002

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access

URL: 

Published: 2017-04-28   Modified: 2023-01-30  

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