Analysis of sleep-wake disturbance in chronic kidney disease based on peripheral blood leukocyte gene profile
| Project/Area Number |
17K17752
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
Neurology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 慢性腎臓病 / 睡眠覚醒障害 / 不眠症 / 認知症 / キラルアミノ酸 / 認知機能障害 / 睡眠障害 / Dアミノ酸 / 認知機能低下 / 糖尿病 |
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| Outline of Final Research Achievements |
Sleep-wake disorders and dementia are important issues to be overcome in social life. In patients with chronic kidney disease (CKD), it is known to cause sleep-wake disturbance and cognitive decline. However, pathophysiology of sleep-wake disorders and dementia has not been fully investigated. In this study, we aimed to elucidate the pathology and identify therapeutic target molecules. We evaluated diagnostic methods for higher brain dysfunctions such as sleep-wake disorders and cognitive decline in CKD patients, as well as the identification of blood markers, using multiple measurement systems. As a result, we showed the possibility that chiral amino acids are involved in pathological conditions and could be therapeutic targets.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で得られたキラルアミノ酸の知見は、CKD患者での睡眠覚醒障害や認知機能低下の診断や治療に寄与する可能性のみならず、糖尿病などの他疾患における同病態の解明ならびに治療法の確立に役立つ可能性がある。多くの症例に多大な恩恵を与えるとともに、人的あるいは経済的な社会への恩恵効果も大きいと考えられ、非常に重要な意義があると考える。
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Report
(7 results)
Research Products
(10 results)
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[Journal Article] Intra-brain and plasma levels of L-Serine are associated with cognitive status in patients with CKD. Kid Dis2023
Author(s)
〇Iwata Y*, Nakade Y, Kinoshita M, Sabit H, Nakajima R, Furuichi K, Mita M, Nakane M, Sakai N, Kitajima S, Toyama T, Miyagawa T, Hara A, Shimizu M, Sato K, Oshima M, Nakagawa S, Yamamura Y, Ogura H, Koshino Y, Nakada M, Wada T.
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Journal Title
Kidney Dis (Basel) .
Volume: 9
Issue: 2
Pages: 118-129
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Increased levels of oral Streptococcus-derived D-alanine in patients with chronic kidney disease and diabetes mellitus.2022
Author(s)
Nakade Y, Iwata Y*, Sakai N, Mita M, Nakane M, Hamase K, Suda W, Toyama T, Kitajima S, Hara A, Shimizu M, Ogushi C, Furuichi K, Koshino Y, Morita H, Hattori M, Wada T.
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Journal Title
Sci Rep
Volume: 12
Issue: 1
Pages: 21773-21773
DOI
Related Report
Peer Reviewed / Open Access
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