Development of highly sensitive chiroptical measurements with surface plasmon resonances for analysis of trace amount of chiral molecules
| Project/Area Number |
17K17757
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Analytical chemistry
Physical chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 表面プラズモン / キラル分光分析 / 円二色性測定 / キラル分析 / 円二色性 |
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| Outline of Final Research Achievements |
I developed chiroptical measurement assisted by surface plasmon resonance to analyze microscopic chiral samples spectroscopically. The detection sensitivity of chiral molecules is improved by introducing nonlinear optical detection mode into surface plasmon ellipsometry. I also achieved novel circular dichroism spectrometer for bulk solutions chiral molecules, that has simple configuration consisting two linear polarizer and a quarter wave plate.
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| Academic Significance and Societal Importance of the Research Achievements |
円二色性測定は、タンパク質やアミノ酸だけでなく、薬剤など多くのキラルな分子を分析する方法として用いられてきたが、装置が高額であることや微小試料には適用が困難であることが課題であった。本研究計画で、円二色性測定をより簡易に実現したことや、マイクロメートルスケールの微小キラル試料を計測できる測定法を開発したことは、今後、これらの測定法が生化学など多くの研究分野における分析法として活用できると期待される。
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Report
(3 results)
Research Products
(13 results)
