The roles of high salt intake in hypothalamic inflammation and the pathogenesis of obesity
Project/Area Number |
17K17803
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Metabolomics
Environmental physiology(including physical medicine and nutritional physiology)
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Research Institution | Nagoya University |
Principal Investigator |
Takagi Hiroshi 名古屋大学, 医学部附属病院, 助教 (10792004)
|
Project Period (FY) |
2017-04-01 – 2019-03-31
|
Project Status |
Completed (Fiscal Year 2018)
|
Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 肥満 / 糖尿病 / 視床下部炎症 / 内臓脂肪 / 内科 / 視床下部 / 炎症 |
Outline of Final Research Achievements |
It is not clear whether high sodium intake correlates obesity and diabetes mellitus. Mice were fed with high fat diet (HF) or high fat and high salt diet (HF + HS). HF + HS group showed reduced body weight gain and increased epididymal white adipose tissue. No significant difference in mRNA expression of inflammatory cytokines in the arcuate was observed. HF + HS group showed impaired glucose tolerance and insulin secretion compared with HF.
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Academic Significance and Societal Importance of the Research Achievements |
食塩過剰摂取が肥満や糖尿病の危険因子となるかについては結論が定まっていない。本研究によりマウスにおいて高脂肪食に食塩過剰摂取が加わると、体重増加は抑制されるものの内臓脂肪量が増加し、耐糖能悪化、インスリン分泌不全を来たすことが見出された。その機序として視床下部炎症や中枢神経系を介した代謝制御の関与については今後も検討する必要がある。
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Report
(3 results)
Research Products
(1 results)