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Compensation filter design method for BNCT to achieve optimal dose distribution

Research Project

Project/Area Number 17K17838
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical Physics and Radiological Technology
Quantum beam science
Research InstitutionKyoto University

Principal Investigator

Takata Takushi  京都大学, 複合原子力科学研究所, 助教 (60444478)

Project Period (FY) 2017-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
KeywordsBNCT / 治療計画 / 補償フィルター / ボーラス / 最適化 / 3Dプリンタ / 粒子線治療学 / 量子ビーム医療応用
Outline of Final Research Achievements

In Boron Neutron Capture Therapy (BNCT), compensation filters are sometimes used to enhance the dose distribution near the neutron incident surface. This study suggests a technique for creating the shape of a compensation filter to achieve the most effective dose distribution. This approach shows that using a filter with an optimized shape can maximize the dose to the tumor target while minimizing the dose to healthy tissues.

Academic Significance and Societal Importance of the Research Achievements

BNCTの臨床照射では、従来、矩形や円形といった単純な形状の補償フィルターが用いられおり、その厚さや体表面への配置は経験に基づいて決定されている。本研究で確立した補償フィルターの形状最適化を臨床適用することで、個々の症例毎に最適化された治療照射が可能となる。本研究の成果は、治療効果を最大限に発揮し、かつ、より安全性の高いBNCTの実現に繋がるものと考える。

Report

(7 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (17 results)

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (12 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Development of optimization method for uniform dose distribution on superficial tumor in an accelerator-based boron neutron capture therapy system2023

    • Author(s)
      Sasaki Akinori、Hu Naonori、Matsubayashi Nishiki、Takata Takushi、Sakurai Yoshinori、Suzuki Minoru、Tanaka Hiroki
    • Journal Title

      Journal of Radiation Research

      Volume: - Issue: 3 Pages: 1-10

    • DOI

      10.1093/jrr/rrad020

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intensity-modulated irradiation for superficial tumors by overlapping irradiation fields using intensity modulators in accelerator-based BNCT2022

    • Author(s)
      Sasaki Akinori、Hu Naonori、Takata Takushi、Matsubayashi Nishiki、Sakurai Yoshinori、Suzuki Minoru、Tanaka Hiroki
    • Journal Title

      Journal of Radiation Research

      Volume: 63 Issue: 6 Pages: 866-873

    • DOI

      10.1093/jrr/rrac052

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Development of an irradiation method for superficial tumours using a hydrogel bolus in an accelerator-based BNCT2021

    • Author(s)
      Sasaki Akinori、Tanaka Hiroki、Takata Takushi、Tamari Yuki、Watanabe Tsubasa、Hu Naonori、Kawabata Shinji、Kudo Yoshihiro、Mitsumoto Toshinori、Sakurai Yoshinori、Suzuki Minoru
    • Journal Title

      Biomedical Physics & Engineering Express

      Volume: 8 Issue: 1 Pages: 015015-015015

    • DOI

      10.1088/2057-1976/ac3d73

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of field-of-view and section thickness of diagnostic imaging on thermal neutron flux estimation in dose-planning for boron neutron capture therapy2018

    • Author(s)
      Sato Hiroyuki、Takata Takushi、Sakurai Yoshinori
    • Journal Title

      Radiological Physics and Technology

      Volume: 12 Issue: 1 Pages: 76-85

    • DOI

      10.1007/s12194-018-00494-3

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of a multimodal Monte Carlo based treatment planning system, Radiation Protection Dosimetry2017

    • Author(s)
      Kumada H, Takada K, Sakurai Y, Suzuki M, Takata T, Sakurai H, Matsumura A, Sakae T
    • Journal Title

      Radiation Protection Dosimetry

      Volume: 26 Issue: 1-4 Pages: 1-5

    • DOI

      10.1093/rpd/ncx218

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Study on the Improvement of Neutron Distribution by Overlapping of Irradiation Fields Using Intensity Moderators in Accelerator-based BNCT2022

    • Author(s)
      Akinori Sasaki, Takushi Takata et al.
    • Organizer
      第123回日本医学物理学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Study on the optimization methods of thermal neutron flux distribution by overlapping multiple irradiation fields for superficial tumors in accelerator-based BNCT2021

    • Author(s)
      Sasaki Akinori, Takata Takushi, et. al.
    • Organizer
      19th International Congress on Neutron Capture Therapy
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Optimization of bolus shape for boron neutron capture therapy using epi-thermal neutron beam2021

    • Author(s)
      Takata Takushi, Tanaka Hiroki, Sakurai Yoshinori, et. al.
    • Organizer
      59th Annual Conference of the Particle Therapy Co-Operative Group
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 熱外中性子を用いたBNCTにおけるボーラス形状の最適化 -計算グリッドサイズの検討-2020

    • Author(s)
      高田卓志、田中浩基、櫻井良憲、笹木彬礼、丸橋晃、鈴木実
    • Organizer
      第33回高精度放射線外部照射部会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 熱外中性子を用いたホウ素中性子捕捉療法におけるボーラス形状最適化の検討2019

    • Author(s)
      高田卓志、田中浩基、櫻井良憲、笹木彬礼、丸橋晃、鈴木実
    • Organizer
      第16回日本中性子捕捉療法学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Optimization of bolus shape for boron neutron capture therapy using epi-thermal neutron beam2019

    • Author(s)
      高田卓志、田中浩基、櫻井良憲、笹木彬礼、丸橋晃、鈴木実
    • Organizer
      第118回日本医学物理学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Kinectセンサーを用いた患者位置モニタリングの検討2018

    • Author(s)
      高田卓志、田中浩基、櫻井良憲、玉利勇樹、丸橋晃、鈴木実
    • Organizer
      第15回日本中性子捕捉療法学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Patient-Position Monitoring System for BNCT Irradiation2018

    • Author(s)
      Takuhi Takata、Hiroki Tanaka、Yoshinori Sakurai、Yuki Tamari、Akira Maruhashi、Minoru Suzuki
    • Organizer
      18th International Congress on Neutron Capture Therapy
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dosimetric Comparison of Total Scalp Irradiation in Boron Neutron Capture Therapy Using Thermal and Epithermal Neutron Beams2017

    • Author(s)
      Takushi Takata, Nozomi Fujimoto, Hiroki Tanaka, Yoshinori Sakurai, Minoru Suzuki
    • Organizer
      The 9th Young Researchers' BNCT Meeting
    • Related Report
      2017 Research-status Report
  • [Presentation] Optimization of Whole-Scalp Irradiation Applicator for Boron Neutron Capture Therapy2017

    • Author(s)
      Takushi Takata, Nozomi Fujimoto, Hiroki Tanaka, Yoshinori Sakurai, Minoru Suzuki
    • Organizer
      8th Japan-Korea medical physics joint meeting
    • Related Report
      2017 Research-status Report
  • [Presentation] ホウ素中性子捕捉療法による全頭皮照射-熱束分布均一性の改善-2017

    • Author(s)
      高田卓志、藤本望、田中浩基、櫻井良憲、鈴木実
    • Organizer
      第14回日本中性子捕捉療法学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Feasibility study for usefulness of CBCT image using X-ray equipment on BNCT treatment planning2017

    • Author(s)
      Hiroyuki Sato, Yasushi Ono, Takushi Takata, Yoshinori Sakurai
    • Organizer
      8th Japan-Korea medical physics joint meeting
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2024-01-30  

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