| Project/Area Number |
17K17896
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
General internal medicine(including psychosomatic medicine)
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| Research Institution | Okayama University |
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Principal Investigator |
Fujii Chikako 岡山大学, 医歯薬学総合研究科, 助教 (00534744)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 起立性調節障害 / 酸化ストレス / 酸化ストレスマーカー / バイオマーカー / 新起立試験 |
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| Outline of Final Research Achievements |
We investigated the oxidative stress environment in patients with orthostatic dysregulation. The study was conducted in the pediatric department of Okayama University Hospital with the approval of the Ethics Committee of Okayama University and in compliance with the ethical regulations. Serum d-ROMs and serum BAP levels were measured, and the children were divided into normal and high serum d-ROMs group (>300 U.) and normal and low serum BAP group (＜2200 μmol/l) to examine their background, subtype classification, and truancy status. Although there were no significant differences in gender, age, and subtype classification between the normal and high serum d-ROMs group and the normal and low serum BAP group, there was an association with truancy status at the time of deterioration, which may reflect the susceptibility to severe disease as a predisposition.
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| Academic Significance and Societal Importance of the Research Achievements |
起立性調節障害の病態を評価するバイオマーカーは現在存在してない。今回の研究において、起立性調節障害の病態や症状とバイオマーカーとの関連の一部を明らかにすることができたと考えられる。バイオマーカーは・低～非侵襲的に繰り返し検査できるので、特に小児医学・医療、心身症・神経症医療に適していると考えられる。今後本研究で明らかになった結果をもとにより一層の特異的なマーカーを検討していくことで、起立性調節障害患者の一般病院での診療実施が行いやすくなると考えられる。
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