| Project/Area Number |
17K18044
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
Radiation science
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 冠動脈疾患 / 冠動脈CT / 心臓CT / 超高精細CT / 高精細CT / 狭心症 / 放射線 / 循環器・高血圧 |
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| Outline of Final Research Achievements |
The experimental study using moving coronary phantom was performed. The study showed that (1) coronary stenosis might be overestimated in heart rate of more than 60 bpm and (2) focus spot might affect stenosis quantification.
The clinical study included patients who underwent CCTA with ultra-high-resolution CT followed by invasive coronary angiography (ICA). The diameter stenosis, as determined by CCTA, demonstrated an excellent correlation with ICA and a slight significant overestimation with the agreed range of limits being ± 16%. The median effective radiation dose for CCTA was 5.4 mSv which was clinically acceptable.
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| Academic Significance and Societal Importance of the Research Achievements |
本邦において心臓疾患は癌に次ぐ主要な死因の一つである．本研究では，冠動脈疾患を評価するために超高精細CTを用いた冠動脈CTを臨床使用する際の基盤となるデータを示した．具体的には(1)冠動脈狭窄評価に影響を与える因子，(2)狭窄率計測能，(3)放射線被曝，である．
これらのデータは臨床で患者選択や検査選択を行う際の資料となり，不要な検査や放射線被曝の低減に寄与することが期待できる．
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