| Project/Area Number |
17K18081
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
Metabolomics
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 生理活性ペプチド / 糖尿病 / 糖尿病慢性合併症 / サリューシンβ / 血管障害 / 血管作動性ペプチド / 糖尿病血管障害 |
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| Outline of Final Research Achievements |
We aimed to elucidate the pathophysiological significance of salusin-β in chronic complications of diabetes mellitus. In this study, we successfully established a new sandwich enzyme-linked immunosorbent assay (ELISA) to quantitate plasma free salusin-β concentration, which is more accurate than previous our measurement systems. We evaluated 136 patients with diabetes mellitus. In the results, salusin-β was not significantly difference in patients’ characteristics, such as age, gender, etc. However, salusin-β was correlated with kidney function. And it was suggested that salusin-β was related to chronic diabetic complications, especially diabetic nephropathy.
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| Academic Significance and Societal Importance of the Research Achievements |
今後さらにサリューシンβの病態生理学的意義を明確にしていくことにより、サリューシンβが糖尿病慢性血管障害の新たなターゲットマーカー、ひいては糖尿病合併症の進展予防薬開発のための創薬シーズになる可能性も期待される。
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