| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We investigated the spontaneous activity of pulmonary vein myocardium, which is the cause of the development of atrial fibrillation. Cardiomyocytes were isolated from the pulmonary vein and their Ca2+ kinetics were compared with those of atrial and ventricular muscles. The cell morphology and Ca2+ movement of the myocardium were found to be similar to that of the atrial muscle. This suggests that the cause of the spontaneous activity in the pulmonary vein myocardium is not due to cellular Ca2+ dynamics, but its low K+ current, which is the nature of the myocardium itself. We are now investigating whether the spontaneous activity of pulmonary venous myocardium is affected by endothelial cells and smooth muscle cells.
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