| Project/Area Number |
17K18303
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
Risk sciences of radiation and chemicals
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | N,N-ジメチルアセトアミド / 尿中代謝物濃度測定 / 皮膚吸収 / リスク評価 / HPLC-MSMS / 産業衛生 / 分析化学 / 産業衛生学 / 社会医学 / 生物学的モニタリング / DMAC |
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| Outline of Final Research Achievements |
This study aimed to develop a risk assessment for workers handling N,N-dimethylacetamide. In this study, we developed a method for simultaneous determination of DMAC urinary metabolites using high-performance liquid chromatography-mass spectrometry. In addition, urinary metabolite concentrations were measured in one worker. Then, at an air concentration of 0.15 ppm, only N-hydroxymethyl-N-methylacrtamide (1.27 mg/g creatinine) and S-(Acrtamidomethyl)mercapturic acid (0.24 mg/ g cratinine) were detected in urine.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は皮膚吸収が指摘されているDMACのリスク評価法として尿中代謝物4成分を同時に測定可能な方法を開発したことである．これまでのDMACの尿中代謝物濃度測定は，ガスクロマトグラフを用いたN-メチルアセトアミドの測定法であったが，このリスク評価法は測定精度に欠くという問題が指摘されていた．本研究により，精度の高いリスク評価法を検討するための方法が確立された．
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