| Project/Area Number |
17K19290
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Forestry and Forest Products Science, Applied aquatic science, and related fields
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| Research Institution | Setsunan University (2020)
Kyoto University (2017-2019) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
前川 真吾 京都大学, 情報学研究科, 助教 (30467401)
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| Project Period (FY) |
2017-06-30 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 哺育因子 / ディスカス / ディスカスミルク / 免疫グロブリン / 保育因子 |
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| Outline of Final Research Achievements |
In this study, in order to identify mammalian growth factors in discus milk, we searched for genes induced in the mucus of discus parent fish by RNA sequencing analysis using a next-generation sequencer that can comprehensively analyze gene expression. As a result, immunoglobulins were found as candidates for mammalian growth factors, and their dynamics in the hatchlings suggested that immunoglobulins may be the mammalian growth factors that have been sought for many years.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の結果、ディスカスの仔魚は免疫グロブリンをディスカスミルクからmRNAの形で摂取し、自身の体内に取り込んだ後にタンパク質に翻訳している可能性が示唆された。仔魚が親魚表皮の粘液をついばんだ後に消化管内で小胞中において翻訳が誘導される分子機構を解明することにより、すでに実用化されている種苗生産現場における健苗育成技術として活用することができるだけでなく、仔魚期の生残率が低く種苗生産の困難なウナギ等の養殖魚の初期飼料への応用に寄与することも期待される。
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