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Vascular niche for maintenance of capillary stem cells

Research Project

Project/Area Number 17K19368
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Biology of Cells to Organisms, and related fields
Research InstitutionAsahikawa Medical College

Principal Investigator

Kawabe Jun-ichi  旭川医科大学, 医学部, 教授 (10400087)

Co-Investigator(Kenkyū-buntansha) 松永 行子 (津田行子)  東京大学, 生産技術研究所, 准教授 (00533663)
Project Period (FY) 2017-06-30 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords毛細血管 / 体性幹細胞 / 骨格筋再生 / 血管ニッチ / 幹細胞 / ペリサイト / 骨格筋 / 再生医療
Outline of Final Research Achievements

We found novel somatic stem cells, termed capillary stem cells (CapSCs) isolated from peripheral microvasculature. In this study, we demonstrated that CapSCs contribute to myogenesis in drug-induced muscle damage and dystrophy mice models. These findings suggest that in addition to satellite cells, microvascular cells, CapSCs play an important role for muscular regeneration and maintenance of muscular mass.

Academic Significance and Societal Importance of the Research Achievements

再生能が高い多核細胞である骨格筋線維は、非常に高い頻度で核の入れ替えをしていること、核補充に毛細血管の一部であるCapSCが担っていることを明らかにした。これらの知見は、同細胞を用いた筋ジストロフィー症の治療法への応用の他、高齢化社会を背景に筋肉量が減少し社会生活に支障をきたす(サルコペニア)病態改善にむけた研究戦略の方向性をつけることができた。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (13 results)

All 2020 2019 2018 2017

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (8 results) (of which Invited: 2 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Capillary-resident EphA7(+) pericytes are multipotent cells with anti-ischemic effects through capillary formation.2020

    • Author(s)
      Yoshida Y, Kabara M, Kano K, Horiuchi K, Hayasaka T, Tomita Y, Takehara N, Minoshima A, Aonuma T, Maruyama K, Nakagawa N, Azuma N, Hasebe N, Kawabe JI.
    • Journal Title

      Stem Cells Transl Med

      Volume: 9 Issue: 1 Pages: 120-130

    • DOI

      10.1002/sctm.19-0148

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ninjurin 1 mediates peripheral nerve regeneration through Schwann cell maturation of NG2-positive cells2019

    • Author(s)
      Tomita Yui、Horiuchi Kiwamu、Kano Kohei、Tatsukawa Takamitsu、Matsuo Risa、Hayasaka Taiki、Yoshida Yuri、Kabara Maki、Yasuda Satoshi、Nakajima Keiichi、Nakagawa Naoki、Takehara Naofumi、Okizaki Atsutaka、Hasebe Naoyuki、Kawabe Jun-ichi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 519 Issue: 3 Pages: 462-468

    • DOI

      10.1016/j.bbrc.2019.09.007

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pericyte-Specific Ninjurin1 Deletion Attenuates Vessel Maturation and Blood Flow Recovery in Hind Limb Ischemia.2018

    • Author(s)
      Minoshima A, Hasebe N et al
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 38 Issue: 10 Pages: 2358-2370

    • DOI

      10.1161/atvbaha.118.311375

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A 3D in vitro pericyte-supported microvessel model: visualization and quantitative characterization of multistep angiogenesis.2018

    • Author(s)
      Lee, E, Takahashi H, Pauty J, Kobayashi M, Kato K, Kabara M, Kawabe J, Matunaga YT
    • Journal Title

      J Material Chem B.

      Volume: 6 Pages: 1085-94

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] EphA7+ pericyte is a novel perivascular stem cell for regeneration of skeletal muscles.2019

    • Author(s)
      Kano K, Kawabe J et al.
    • Organizer
      The 42nd Annual Meeting of the Molecular Biology Society of Japan
    • Related Report
      2019 Annual Research Report
  • [Presentation] 日常生活状態における骨格筋組織の再生・維持に毛細血管周細胞が重要である2019

    • Author(s)
      鹿野耕平、内田紗英子、鈴木勇太、堀内至、澤田潤、長谷部直幸、川辺淳一
    • Organizer
      第31回日本老年学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Identification of Capillary stem cells having capillary formation and potent regenerative potency2018

    • Author(s)
      吉田 有里 、鹿原 真樹 、鹿野 耕平 、早坂 太希 、富田 唯 、堀内 至 、簑島 暁帆 、齊藤 幸裕 、西村 正人 、竹原 有史 、東 信良 、長谷部 直幸 、川辺 淳一
    • Organizer
      第1回日本循環器基礎研究フォーラムBCVR
    • Related Report
      2018 Research-status Report
  • [Presentation] Visualization and quantification of pericyte incorporated 3D in vitro angiogenesis2018

    • Author(s)
      Lee E, Takahashi H, Pauty J, Kabara M, Kawabe J, Matsunaga Y
    • Organizer
      第26回日本血管生物医学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 毛細血管幹細胞(Capillary Stem Cells(CapSCs))による骨格筋再生2018

    • Author(s)
      鹿野耕平、鹿原真樹、堀内至、早坂太希、吉田有里、富田唯、丸山啓介、澤田潤、蓑島暁帆、中川直樹、竹原有史、長谷部直幸、川辺 淳一
    • Organizer
      第26回日本血管生物医学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Capillary stem cells, multipotent pericytes resident in microvessels and their clinical application2018

    • Author(s)
      Kawabe J
    • Organizer
      第41回  日本分子生物学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Capillary pericytes provide a new insight in vital phenomenon of multicellular organism.2018

    • Author(s)
      Kawabe J
    • Organizer
      第41回  日本高血圧学会総会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 多分化能をもつ毛細血管幹細胞(Capillary Stem Cells)の同定とその組織再生能の検討2017

    • Author(s)
      吉田有里、川辺淳一ら
    • Organizer
      第25回 日本血管生物医学学術集会
    • Related Report
      2017 Research-status Report
  • [Patent(Industrial Property Rights)] 毛細血管由来幹細胞 その用途および製造方法2017

    • Inventor(s)
      川辺淳一
    • Industrial Property Rights Holder
      川辺淳一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2018 Research-status Report
    • Overseas

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Published: 2017-07-21   Modified: 2021-02-19  

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