Vascular niche for maintenance of capillary stem cells
| Project/Area Number |
17K19368
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biology of Cells to Organisms, and related fields
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松永 行子 (津田行子) 東京大学, 生産技術研究所, 准教授 (00533663)
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| Project Period (FY) |
2017-06-30 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 毛細血管 / 体性幹細胞 / 骨格筋再生 / 血管ニッチ / 幹細胞 / ペリサイト / 骨格筋 / 再生医療 |
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| Outline of Final Research Achievements |
We found novel somatic stem cells, termed capillary stem cells (CapSCs) isolated from peripheral microvasculature. In this study, we demonstrated that CapSCs contribute to myogenesis in drug-induced muscle damage and dystrophy mice models. These findings suggest that in addition to satellite cells, microvascular cells, CapSCs play an important role for muscular regeneration and maintenance of muscular mass.
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| Academic Significance and Societal Importance of the Research Achievements |
再生能が高い多核細胞である骨格筋線維は、非常に高い頻度で核の入れ替えをしていること、核補充に毛細血管の一部であるCapSCが担っていることを明らかにした。これらの知見は、同細胞を用いた筋ジストロフィー症の治療法への応用の他、高齢化社会を背景に筋肉量が減少し社会生活に支障をきたす（サルコペニア）病態改善にむけた研究戦略の方向性をつけることができた。
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Capillary-resident EphA7(+) pericytes are multipotent cells with anti-ischemic effects through capillary formation.2020
Author(s)
Yoshida Y, Kabara M, Kano K, Horiuchi K, Hayasaka T, Tomita Y, Takehara N, Minoshima A, Aonuma T, Maruyama K, Nakagawa N, Azuma N, Hasebe N, Kawabe JI.
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Journal Title
Stem Cells Transl Med
Volume: 9
Issue: 1
Pages: 120-130
DOI
Related Report
Peer Reviewed / Open Access
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