| Project/Area Number |
17K19416
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biology of Cells to Organisms, and related fields
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Nozaki Tomoyoshi 東京大学, 大学院医学系研究科(医学部), 教授 (60198588)
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| Co-Investigator(Kenkyū-buntansha) |
サントス ハルベルト・ヒメネス 東京大学, 大学院医学系研究科(医学部), 助教 (90793779)
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| Project Period (FY) |
2017-06-30 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 進化 / オルガネラ / ミトコンドリア / 代謝 / 内部共生 |
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| Outline of Final Research Achievements |
We characterized two proteins involved in mitosome (uniquely evolved mitochondrion-related organelle in anaerobic eukaryotic cells)-vesicle contact, which possibly allows substrate/product transport and quality control of mitosomes. We concluded by various experimental approaches using biochemistry, cell biology, and genetics that ETMP1, a novel lineage-specific mitosomal transmembrane protein, interacts with EHD-domain containing proteins, which are localized to a variety of vesicles/vacuoles. Thus, this study shed new light on organellogenesis in eukaryotes.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果により、酸素の中で進化をした真核生物において、その中の細菌の内部共生に由来してできたミトコンドリアに似た細胞内小器官であるマイトソームの細胞内での相互作用を担うタンパク質が同定された。様々な環境の中で進化するオルガネラの多様性の一端が解明された。
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