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Establishing Multiple-Scale Connectomics

Research Project

Project/Area Number 17K19456
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Neuroscience and related fields
Research InstitutionKyoto University

Principal Investigator

shimono masanori  京都大学, 医学研究科, 特定准教授 (30552137)

Project Period (FY) 2017-06-30 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Keywords神経 / 脳 / ネットワーク / 3Dスキャン / ビックデータ / 非一様 / 抑制細胞 / 情報 / ニューラルネットワーク / ニューロン / データベース / コネクトーム / 局所回路 / 多電極計測 / マルチスケール / 多ニューロン計測
Outline of Final Research Achievements

Since last year, the company has developed a (Construct and analyze networks that include inhibitory cells) method that improves on its network construction methods. New findings from this approach have been published and published in BioRxiv [Kajiwara et al., 2019]. We have also accumulated systematic measurements from multiple brain regions using a method developed in 2018 to implant microcircuits into the whole brain using 3D scanning images. It is expected that the non-uniform differences among the brain regions of the microcircuits obtained in these accumulations will develope to contribute to greatly enhancing the realism of computational models in the near future.

Academic Significance and Societal Importance of the Research Achievements

脳は、100億のオーダーの数の神経細胞が繋がって出来ている。その細胞間のつながりは、単にランダムではなく、ある種の構造だった複雑性を有している。そして、脳領域間で、その特性は異なっている(非一様である)。そして、その非一様さを体系的に計測する事は、国家的なビックプロジェクトではないと難しいと専門家でも思っている者も多い。そこを、多細胞の計測と分析手法を成熟させ、3Dスキャンを活用する新たな切り口で、現実的に大目標を体系的に前進させている。この様な研究が、脳がもし疾患になるとどうなるのか、を予測した結果を解釈したりする助けとなるリアリティを有した数理モデルにつながる確実な道の一つである。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (23 results)

All 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (9 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results) Book (1 results) Remarks (9 results)

  • [Int'l Joint Research] taiwan/national central univerisity(その他の国・地域)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Inhibitory neurons in somato-motor cortex are highly central and also show high controllability.2020

    • Author(s)
      Kajiwara, M., Goetze F., …,Akutsu T., Shimono M.
    • Journal Title

      bioRxiv

      Volume: 1208 Pages: 954016-954016

    • DOI

      10.1101/2020.02.18.954016

    • Related Report
      2019 Annual Research Report
    • Open Access / Int'l Joint Research
  • [Journal Article] 3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol.2019

    • Author(s)
      Ide, S., Kajiwara, M., Imai, H., & Shimono, M.
    • Journal Title

      J. Vis. Exp.

      Volume: 147 Issue: 147

    • DOI

      10.3791/58911

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficient communication dynamics on macro-connectome, and the propagation speed2018

    • Author(s)
      Shimono Masanori、Hatano Naomichi
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 2510-2510

    • DOI

      10.1038/s41598-018-20591-y

    • NAID

      120006510276

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Neural network embedding of real neuronal networks [オーラル, 審査あり]2020

    • Author(s)
      Hase T., Shimono M.
    • Organizer
      NetSciX 2020
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Natural embeddiment of microconnectome to bridge a scale gap.2019

    • Author(s)
      Kajiwara, M., Ide, S., Imai, H., Shimono, M.
    • Organizer
      Network Science seminar 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] [An introductory talk] From Neuroscience to Network Science (招待講演)2019

    • Author(s)
      Shimono M.
    • Organizer
      Network Science seminar 2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Multi-scale Comparison Visualization System of Mouse Brain. (国際学会)2019

    • Author(s)
      L. Puwen, H. Natsukawa, M. Shimono, K. Koyamada
    • Organizer
      PasificVis 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Excitatory and Inhibitory Information flows on Micriconnectome [オーラル, 審査あり]2019

    • Author(s)
      Motoki Kajiwara, Felix Goetz, Akitoshi Seiyama, Masanori Shimono
    • Organizer
      Neuro2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Basic topologies of E/I categorized microconnectome.2019

    • Author(s)
      梶原基, 下野 昌宣
    • Organizer
      次世代脳シンホジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Multi-scale Comparison Visualization System of Mouse Brain.2019

    • Author(s)
      L. Puwen, H. Natsukawa, M. Shimono, K. Koyamada
    • Organizer
      PasificVis 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Natural embeddiment of microconnectome to bridge a scale gap.2018

    • Author(s)
      Kajiwara, M., Ide, S., Imai, H., Shimono, M.,
    • Organizer
      Network Science seminar 2019
    • Related Report
      2018 Research-status Report
  • [Presentation] [An introductory talk] From Neuroscience to Network Science2018

    • Author(s)
      Shimono M.
    • Organizer
      Network Science seminar 2019
    • Related Report
      2018 Research-status Report
    • Invited
  • [Book] 脳のネットワーク2020

    • Author(s)
      オラフ スポーンズ著, 下野昌宣 訳
    • Total Pages
      408
    • Publisher
      みすす書房
    • ISBN
      9784622088844
    • Related Report
      2019 Annual Research Report
  • [Remarks] 3D Scanning Technology Bridging Micro and Macro

    • URL

      https://www.jove.com/video/58911/3d-scanning-technology-bridging-microcircuits-macroscale-brain-images

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
  • [Remarks] @Sci_Ani

    • URL

      https://twitter.com/Sci_Ani/status/1128223237303951360

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
  • [Remarks] Bridging scales of brain

    • URL

      https://www.nationaltribune.com.au/bridging-scales-of-brain/

    • Related Report
      2019 Annual Research Report
  • [Remarks] Bridging scales of brain

    • URL

      https://www.miragenews.com/bridging-scales-of-brain/

    • Related Report
      2019 Annual Research Report
  • [Remarks] シリーズ白眉対談14「実験と理論とシミュレーション」

    • URL

      https://www.hakubi.kyoto-u.ac.jp/pub/nl15/Newsletter015-03.pdf

    • Related Report
      2019 Annual Research Report
  • [Remarks] Multi-Scale Neural Networks Laboratory

    • URL

      http://shimono-u.net/

    • Related Report
      2018 Research-status Report 2017 Research-status Report
  • [Remarks] シリーズ白眉対談⑭「実験と理論とシミュレーション」

    • URL

      https://www.hakubi.kyoto-u.ac.jp/pub/nl15/Newsletter015-03.pdf

    • Related Report
      2018 Research-status Report
  • [Remarks] @JoVE_Editorial

    • URL

      https://twitter.com/JoVE_Editorial/status/1128034679943098368

    • Related Report
      2018 Research-status Report
  • [Remarks] 京都大学教育研究活動データベース

    • URL

      https://kyouindb.iimc.kyoto-u.ac.jp/j/xY5zE

    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-07-21   Modified: 2021-02-19  

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