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Development of single cell-based technologies for iPSC-neurons from patients with schizophrenia

Research Project

Project/Area Number 17K19488
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Pharmaceutical Sciences and related fields
Research InstitutionOsaka University

Principal Investigator

Hashimoto Hitoshi  大阪大学, 薬学研究科, 教授 (30240849)

Project Period (FY) 2017-06-30 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
KeywordsiPS細胞 / 単一細胞解析 / 患者神経細胞 / 統合失調症 / 単細胞解析
Outline of Final Research Achievements

In this study, we have developed a series of recombinant lentiviruses expressing a fluorescent Venus protein under the control of promoters from various cell-type-specific marker genes for constructing cell-type specific labeling systems for iPSC-differentiated neurons from patients with psychiatric disorders. Using lentiviruses, we have successfully separated cell-type specific neurons from iPSC-differentiated neurons, in which there are many cell types such as excitatory and inhibitory neurons. The cell-type specific labeling systems we have developed in this study contribute to elucidating molecular etiology of psychiatric disorders at a single cell level.

Academic Significance and Societal Importance of the Research Achievements

ヒトiPS細胞から神経細胞を分化させる研究が再生医療のみならず脳・疾患研究や創薬への応用を目指して盛んに進められているが、未だ機能的に十分に成熟した細胞は得られておらず、また特定の神経細胞種のみを得ることができないのが現状である。そのような状況のもと、特定の神経細胞種を分取・解析する基盤技術を開発した本研究は、高い分化効率および特定の神経細胞種の分離を達成することを可能にし、疾患の本質にせまることに貢献することが期待されることから学術的重要性が高い。また、実現性の高い創薬研究を可能にすることが期待されることから社会的な要求性が高いものである。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (81 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (10 results) Journal Article (16 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 16 results,  Open Access: 16 results) Presentation (53 results) (of which Int'l Joint Research: 17 results,  Invited: 13 results) Book (1 results) Remarks (1 results)

  • [Int'l Joint Research] University of California, Los Angels/Northwestern University/New York Medical College(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Pecs/University of Szeged/University of Debrecen(ハンガリー)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Bristol(英国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Heidelberg(ドイツ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Liege(ベルギー)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of California, Los Angeles/Northwestern University/New York Medical College(米国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] University of Pecs/University of Szeged/University of Debrecen(ハンガリー)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] University of Bristol(英国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] University of Heidelberg(ドイツ)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] University of Liege(ベルギー)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Direct visualization of an antidepressant analog using surface-enhanced Raman scattering in the brain2020

    • Author(s)
      Masato Tanuma, Atsushi Kasai, Kazuki Bando, Naoyuki Kotoku, Kazuo Harada, Masafumi Minoshima, Kosuke Higashino, Atsushi Kimishima, Masayoshi Arai, Yukio Ago, Kaoru Seiriki, Kazuya Kikuchi, Satoshi Kawata, Katsumasa Fujita, Hitoshi Hashimoto
    • Journal Title

      JCI Insight

      Volume: 5 Issue: 6

    • DOI

      10.1172/jci.insight.133348

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes.2020

    • Author(s)
      Matsumura K, (33名中略), Hashimoto R, (37名中35番目),Hashimoto H, Nakazawa T.
    • Journal Title

      Nat. Commun

      Volume: 11(1) Issue: 1 Pages: 859-859

    • DOI

      10.1038/s41467-020-14697-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Current Perspective: Modeling of psychiatric disorders using induced pluripotent stem cell-related technologies.2019

    • Author(s)
      Nakazawa T, Hashimoto R, Takuma K, Hashimoto H.
    • Journal Title

      J Pharmacol Sci,

      Volume: 140(4) Issue: 4 Pages: 321-324

    • DOI

      10.1016/j.jphs.2019.06.002

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Autism-associated protein kinase D2 regulates embryonic cortical neuron development.2019

    • Author(s)
      Matsumura K, Baba M, Nagayasu K, Yamamoto K, Kondo M, Kitagawa K, Takemoto T, Seiriki K, Kasai A, Ago Y, Hayata-Takano A, Shintani N, Kuriu T, Iguchi T, Sato M, Takuma K, Hashimoto R, Hashimoto H.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 519(3) Issue: 3 Pages: 626-632

    • DOI

      10.1016/j.bbrc.2019.09.048

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome.2019

    • Author(s)
      Baba M, Yokoyama K, Seiriki K, Naka Y, Matsumura K, Kondo M, Yamamoto K, Hayashida M, Kasai A, Ago Y, Nagayasu K, Hayata-Takano A, Takahashi A, Yamaguchi S, Mori D, Ozaki N, Yamamoto T, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T.
    • Journal Title

      Neuropsychopharmacology

      Volume: 44(12) Issue: 12 Pages: 2125-2135

    • DOI

      10.1038/s41386-019-0441-5

    • NAID

      130007811380

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pituitary adenylate cyclase-activating polypeptide modulates dendritic spine maturation and morphogenesis via microRNA-132 upregulation.2019

    • Author(s)
      Hayata-Takano A, Kamo T, Kijima H, Seiriki K, Ogata K, Ago Y, Nakazawa T, Shintani Y, Higashino K, Nagayasu K, Shintani N, Kasai A, Waschek JA, Hashimoto H.
    • Journal Title

      J Neurosci.

      Volume: 印刷中 Issue: 22 Pages: 4208-4220

    • DOI

      10.1523/jneurosci.2468-18.2019

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Whole-brain block-face serial microscopy tomography at subcellular resolution using FAST.2019

    • Author(s)
      Seiriki K, Kasai A, Nakazawa T, Niu M, Naka Y, Tanuma M, Igarashi H, Yamaura K, Hayata-Takano A, Ago Y, Hashimoto H.
    • Journal Title

      Nat Protoc.

      Volume: 印刷中 Issue: 5 Pages: 1509-1529

    • DOI

      10.1038/s41596-019-0148-4

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model.2019

    • Author(s)
      Kawase H, Ago Y, Naito M, Higuchi M, Hara Y, Hasebe S, Tsukada S, Kasai A, Nakazawa T, Mishina T, Kouji H, Takuma K, Hashimoto H.
    • Journal Title

      Pharmacol Biochem Behav.

      Volume: 176 Pages: 1-5

    • DOI

      10.1016/j.pbb.2018.11.003

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] VPAC1 receptors play a dominant role in PACAP-induced vasorelaxation in female mice.2019

    • Author(s)
      Ivic I, Balasko M, Fulop BD, Hashimoto H, Toth G, Tamas A, Juhasz T, Koller A, Reglodi D, Solymar M.
    • Journal Title

      PLoS One

      Volume: 14 Issue: 1 Pages: e0211433-e0211433

    • DOI

      10.1371/journal.pone.0211433

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association of Serotonin2c Receptor Polymorphisms With Antipsychotic Drug Response in Schizophrenia.2019

    • Author(s)
      Li J, Hashimoto H, Meltzer HY.
    • Journal Title

      Front Psychiatry.

      Volume: 10 Pages: 58-58

    • DOI

      10.3389/fpsyt.2019.00058

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Targeted knockdown of the mitochondria-localized protein p13 protects against experimental parkinsonism2018

    • Author(s)
      Inoue N, Ogura S, Kasai A, Nakazawa T, Ikeda K, Higashi S, Isotani A, Baba K, Mochizuki H, Fujimura H, Ago Y, Hayata-Takano A, Seiriki K, Shintani N, Hashimoto H
    • Journal Title

      EMBO Reports

      Volume: 19(3) Issue: 3

    • DOI

      10.15252/embr.201744860

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking.2018

    • Author(s)
      Shintani Y, Hayata-Takano A, Moriguchi K, Nakazawa T, Ago Y, Kasai A, Seiriki K, Shintani N, Hashimoto H.
    • Journal Title

      PLoS One

      Volume: 13 Issue: 5 Pages: e0196946-e0196946

    • DOI

      10.1371/journal.pone.0196946

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Accelerated pre-senile systemic amyloidosis in PACAP knockout mice - a protective role of PACAP in age-related degenerative processes.2018

    • Author(s)
      Reglodi D, Jungling A, Longueesp R, Kriegsmann J, Casadonte R, Kriegsmann M, Juhasz T, Bardosi S, Tamas A, Fulop BD, Kovacs K, Nagy Z, Sparks J, Miseta A, Mazzucchelli G, Hashimoto H, Bardosi A.
    • Journal Title

      J. Pathol.

      Volume: 245 Issue: 4 Pages: 478-490

    • DOI

      10.1002/path.5100

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Manipulation of dorsal raphe serotonergic neurons modulates active coping to inescapable stress and anxiety-related behaviors in mice and rats.2018

    • Author(s)
      Nishitani N, Nagayasu K, Asaoka N, Yamashiro M, Andoh C, Nagai Y, Kinoshita H, Kawai H, Shibui N, Liu B, Hewinson J, Shirakawa H, Nakagawa T, Hashimoto H, Kasparov S, Kaneko S.
    • Journal Title

      Neuropsychopharmacology

      Volume: 44 Issue: 4 Pages: 721-732

    • DOI

      10.1038/s41386-018-0254-y

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] High-speed and scalable whole-brain imaging in rodents and primates2017

    • Author(s)
      Seiriki K, Kasai A, Hashimoto T, Schulze W, Niu M, Yamaguchi S, Nakazawa T, Inoue K, Uezono S, Takada M, Naka Y, Igarashi H, Tanuma M, Waschek JA, Ago Y, Tanaka KF, Hayata-Takano A, Nagayasu K, Shintani N, Hashimoto R, Kunii Y, Hino M, Matsumoto J, Yabe H, Nagai T, Fujita K, Matsuda T, Takuma K, Baba A, Hashimoto H
    • Journal Title

      Neuron

      Volume: 94 Issue: 6 Pages: 1085-1100

    • DOI

      10.1016/j.neuron.2017.05.017

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prenatal exposure to valproic acid increases miR-132 levels in the mouse embryonic brain.2017

    • Author(s)
      Hara Y, Ago Y, Takano E, Hasebe S, Nakazawa T, Hashimoto H, Matsuda T, Takuma K.
    • Journal Title

      Molecular Autism

      Volume: 8 Issue: 1 Pages: 33-33

    • DOI

      10.1186/s13229-017-0149-5

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ヒトiPS細胞技術を用いた精神疾患モデルの開発2020

    • Author(s)
      中澤敬信、橋本亮太、田熊一敞、橋本均
    • Organizer
      第93回日本薬理学会年会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] iPS細胞を用いた精神疾患のメカニズム研究と創薬への応用2020

    • Author(s)
      中澤敬信、橋本亮太、田熊一敞、橋本均
    • Organizer
      第93回日本薬理学会年会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 社会的敗北ストレスによって活性化する前障神経細胞はストレス応答に関わる神経核の活動調整を介して不安様行動を調節する2020

    • Author(s)
      丹生 光咲、笠井 淳司、桑木 崇宏、田沼 将人、勢力 薫、中澤 敬信、山中 章弘、橋本 均
    • Organizer
      第93回日本薬理学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 3q29欠失症候群モデルマウスにおける精神疾患様の行動異常と大脳皮質神経細胞の過活動2020

    • Author(s)
      Masayuki Baba, Kazumasa Yokoyama, Kaoru Seiriki, Kensuke Matsumura, Momoka Kondo, Kana Yamamoto, Atsushi Kasai, Yukio Ago, Kazuki Nagayasu, Atsuko Hayata-Takano, Shun Yamaguchi, Daisuke Mori, Norio Ozaki, Tadashi Yamamoto, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto and Takanobu Nakazawa
    • Organizer
      第93回日本薬理学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Optical and computational dissection of neural circuit for fear memory2020

    • Author(s)
      Agetsuma M., Sato I., Tanaka Y., Kasai A., Arai Y., Yoshitomo M., Hashimoto H., Nabekura J., Nagai T.
    • Organizer
      第98回日本生理学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 自閉症モデルマウスの社会性行動障害の改善に関わる脳領域の探索2019

    • Author(s)
      彌永 祐輔、笠井 淳司、五十嵐 久人、原 雄大、三浦 大樹、勢力 薫、田沼 将人、山浦 港生、中澤 敬信、吾郷 由希夫、山口 瞬、田熊 一敞、橋本 均
    • Organizer
      第135回日本薬理学会近畿部会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 脳内シンギュラリティ細胞の探索を目指した全脳イメージングとアンバイアス解析2019

    • Author(s)
      橋本均、中澤敬信
    • Organizer
      第19回日本蛋白質科学会年会・第71回日本細胞生物学会大会 合同年次大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 高速・高拡張性全脳イメージングシステムFAST:アンバイアス、仮説フリーでの薬物の有効性と安全性の評価へ2019

    • Author(s)
      橋本均
    • Organizer
      第46回日本毒性学会学術年会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 高速・高精細全脳イメージングによる脳機能解析2019

    • Author(s)
      橋本均
    • Organizer
      第44回レーザ顕微鏡研究会&シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 脳内のシンギュラリティ検出のための全脳高解像度イメージング2019

    • Author(s)
      勢力 薫 笠井 淳司  中澤 敬信  橋本 均
    • Organizer
      Neuro2019 (第42回日本神経科学学会・ 第62回日本神経化学会大会合同大会)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 単一細胞 RNA seq によるストレス応答性神経細胞の特性解析2019

    • Author(s)
      田沼 将人 笠井 淳司 奥野 浩行 山浦 港生  丹生 光咲 勢力 薫  中澤 敬信  山口 瞬  橋本 均
    • Organizer
      Neuro2019 (第42回日本神経科学学会・ 第62回日本神経化学会大会合同大会)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 自閉スペクトラム症関連遺伝子POGZの患者特異的de novo変異の大脳皮質神経分化における表現型解析2019

    • Author(s)
      松村 憲佑  勢力 薫 永瀬 将志 綾部 信哉  山田 郁子  古瀬 民生 山本 果奈  北川 航平  猪口 徳一  佐藤 真  山口 瞬  田村 勝  若菜 茂晴  吉木 淳 渡部 文子 岡野 栄之  田熊 一敞  橋本 亮太 橋本 均 中澤 敬信
    • Organizer
      Neuro2019 (第42回日本神経科学学会・ 第62回日本神経化学会大会合同大会)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 多発家系患者のiPS分化神経細胞を用いた統合失調症の分子病態解析2019

    • Author(s)
      山本 果奈 栗生 俊彦 中澤 敬信  松村 憲佑 永安 一樹  馬場 優志  山森 英長  安田 由華  藤本 美智子  鶴崎 美徳  松本 直通  田熊 一敞  橋本 亮太  橋本 均
    • Organizer
      Neuro2019 (第42回日本神経科学学会・ 第62回日本神経化学会大会合同大会)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 前障の興奮性神経細胞はカテコラミンの放出を介して不安様行動を制御する2019

    • Author(s)
      Misaki Niu, Atsushi Kasai, Hisato Igarashi, Wataru Tanabe, Takahiro Kuwaki, Masato Tanuma, Kaoru Seiriki, Yukio Ago, Takanobu Nakazawa, Akihiro Yamanaka, Hitoshi Hashimoto
    • Organizer
      Neuro2019 (第42回日本神経科学学会・ 第62回日本神経化学会大会合同大会)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 全脳活動マッピングを用いた情動行動制御機構の解明2019

    • Author(s)
      笠井淳司、橋本均
    • Organizer
      生体機能と創薬シンポジウム2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 蛍光全脳イメージングのための連続断層イメージング法FAST2019

    • Author(s)
      勢力薫、橋本均
    • Organizer
      第57回日本生物物理学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 全脳イメージングシステムFASTを用いたアンバイアスで仮説に依らない脳内シンギュラリティの検出2019

    • Author(s)
      橋本均、中澤敬信、勢力薫、笠井淳司
    • Organizer
      第57回日本生物物理学会年会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Differential behavioral and neurochemical effects of ketamine enantiomers and their metabolites2019

    • Author(s)
      Yukio Ago, Hitoshi Hashimoto
    • Organizer
      AsCNP2019第6回アジア神経精神薬理学会
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Generation of serotonergic neurons from human induced pluripotent stem cells through forced expression of serotonin neuron-specific transcription factors.2019

    • Author(s)
      Yuma Nagai, Kazuki Nagayasu, Konomi Masunaka, Yukio Ago, Atsushi Kasai, Hisashi Shirakawa, Takanobu Nakazawa, Hitoshi Hashimoto, Shuji Kaneko
    • Organizer
      AsCNP2019第6回アジア神経精神薬理学会
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vivo imaging of alkynylated S-citalopram using surface-enhanced Raman scattering2019

    • Author(s)
      Masato Tanuma, Atsushi Kasai, Kazuki Bando, Naoyuki Kotoku, Kosuke Higashino, Yukio Ago, Satoshi Kawata, Katsumasa Fujita, Hitoshi Hashimoto
    • Organizer
      Neuroscience 2019(Society for Neuroscience)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Singularity Biology: small elements change the function of the whole systems2019

    • Author(s)
      Kazuki Horikawa,Hiroko Bannnai,Hitoshi Hashimoto
    • Organizer
      ICSB2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pituitary Adenylate Cyclase-Activating Polypeptide in the Ventromedial Hypothalamus Increased Appetite Through the Change of Neuropeptides Expression in the Arcuate Nucleus of Mice2019

    • Author(s)
      Yuki Kambe, Thanh Trung Nguyen, Takashi Kurihara, Tomoya Nakamachi, Norihito Shintani, Hitoshi Hashimoto and Atsuro Miyata
    • Organizer
      The Akira Arimura Memorial VIP/PACAP and Related Peptides Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of PACAP signaling for functional synapse formation in the hippocampal neurons2019

    • Author(s)
      Atsuko Hayata-Takano, Harui Kijima, Toshihiko Kamo, Kaoru Seiriki, Yusuke Shintani, Takanobu Nakazawa, Hitoshi Hashimoto
    • Organizer
      The Akira Arimura Memorial VIP/PACAP and Related Peptides Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 単一細胞RNA seqによるストレス応答性神経細胞の特性解析2019

    • Author(s)
      田沼将人、笠井淳司、奥野浩行、山浦港生、丹生光咲、勢力薫、中澤敬信、山口瞬、橋本均
    • Organizer
      第92回 日本薬理学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 脳疾患の病態解析と創薬へ向けたアンバイアス全脳イメージング2019

    • Author(s)
      橋本均
    • Organizer
      第92回 日本薬理学会年会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 前障神経の活性化はカテコラミン放出を介して不安様行動を引き起こす2019

    • Author(s)
      笠井淳司、丹生光咲、桑木崇宏、田邊航、田沼将人、五十嵐久人、吾郷由希夫、勢力薫、中澤敬信、橋本均
    • Organizer
      第92回 日本薬理学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Involvement of miR-132 in PACAP-dependent morphological changes of dendritic spines.2018

    • Author(s)
      Hayata-Takano A, Kijima H, Kamo T, Shintani Y, Ago Y, Seiriki K, Nakazawa T, Shintani N, Hashimoto H
    • Organizer
      CINP World Congress 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Whole-brain mapping of neuronal activity in mice after social defeat stress2018

    • Author(s)
      Igarashi H, Kasai A, Niu M, Seiriki K, Kuwaki T, Tanuma M, Yamaguchi S, Nakazawa T, Hashimoto H
    • Organizer
      World Congress of Basic and Clinical Pharmacology (WCP2018 KYOTO)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Protein kinase D2 (PRKD2) regulates embryonic neural development2018

    • Author(s)
      Baba M, Matsumura K, Nakazawa T, Nagayasu K, Kasai A, Takuma K, Hashimoto H
    • Organizer
      World Congress of Basic and Clinical Pharmacology (WCP2018 KYOTO)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] The de novo Q1042R POGZ mutation in sporadic ASD disrupts the neuronal differentiation2018

    • Author(s)
      Matsumura K, Nakazawa T, Okada S, Nagayasu K, Miura H, Kasai A, Takuma K, Yamamori H, Yasuda Y, Hashimoto R, Hashimoto H
    • Organizer
      World Congress of Basic and Clinical Pharmacology (WCP2018 KYOTO)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 多発家系患者のiPS分化神経細胞を用いた統合失調症の分子病態解析2018

    • Author(s)
      山本果奈、松村憲佑、中澤敬信、永安一樹、栗生俊彦、馬場優志、田熊一敞、鶴崎美徳、安田由華、山森英長、松本直通、橋本亮太、橋本均
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2018
    • Related Report
      2018 Research-status Report
  • [Presentation] 複数の自閉症スペクトラム障害患者にde novo変異が認められるPRKD2は神経発達に関与する2018

    • Author(s)
      馬場優志、松村憲佑、中澤敬信、永安一樹、笠井淳司、田熊一敞、橋本均
    • Organizer
      第61回 日本神経化学会大会・第40回日本生物学的精神医学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Chd8ヘテロ欠損マウス巨脳では大脳皮質と扁桃体の細胞数が増加し神経細胞が減少する2018

    • Author(s)
      笠井淳司、中雄一郎、片山雄太、彌永祐輔、山浦港生、田沼将人、勢力薫、中澤敬信、中山敬一、橋本均
    • Organizer
      第61回 日本神経化学会大会・第40回日本生物学的精神医学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 高速・高拡張性全脳イメージングシステムFAST:アンバイアスで仮説フリーに脳内のシンギュラリティを検出する手法へ2018

    • Author(s)
      橋本均、笠井淳司、勢力薫、中澤敬信
    • Organizer
      第56回 日本生物物理学会年会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Claustrum is involved in stress-induced anxiety-like behaviors2018

    • Author(s)
      Kasai A, Niu M, Seiriki K, Igarashi H, Tanuma M, Kuwaki T, Nagayasu K, Yamaguchi S, Nakazawa T, Yamanaka A, Hashimoto H
    • Organizer
      Cold Spring Harbor Laboratory Meeting (Molecular mechanisms of neuronal connectivity)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 高精細全脳イメージング技術FASTの開発と精神疾患モデルマウスの病態解析2018

    • Author(s)
      勢力薫、笠井淳司、丹生光咲、田沼将人、五十嵐久人、中澤敬信、山口瞬、井上謙一、高田昌彦、橋本均
    • Organizer
      第68回 日本薬学会近畿支部総会・大会
    • Related Report
      2018 Research-status Report
  • [Presentation] High-speed and high-resolution whole-brain imaging system FAST (block-face-serial-microscopy tomography)2018

    • Author(s)
      Hashimoto H, Seiriki K, Kasai A, Nakazawa T
    • Organizer
      Cold Spring Harbor Conference Asia
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Whole-brain analysis of the NMDA receptor antagonist-induced neuronal activation in mice using hifh-speed and high-resolution imaging system FAST (block-face serial microscopy tomography)2018

    • Author(s)
      Seiriki K, Kasai A, Nakazawa T, Hashimoto H
    • Organizer
      Cold Spring Harbor Conference Asia
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] iPS細胞関連技術とヒト型疾患モデルマウスを用いた精神疾患の分子病態解析2018

    • Author(s)
      中澤敬信、橋本亮太、田熊一敞、橋本均
    • Organizer
      第28回日本臨床精神神経薬理学会 第48回日本神経精神薬理学会 合同年会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] マウス新生仔へのプロスタグランジンD2受容体DP1作動薬による神経細胞の形態 や行動への影響2018

    • Author(s)
      早田敦子、奥田健太、毛利育子、橘雅弥、新谷勇介、菊池泰河、中澤敬信、谷池雅子、橋本均
    • Organizer
      第28回日本臨床精神神経薬理学会 第48回日本神経精神薬理学会 合同年会
    • Related Report
      2018 Research-status Report
  • [Presentation] (R)-ketamine, (S)-ketamine and their metabolites affect differentially in vivo monoamine release in the prefrontal cortex of mice: Different involvement of AMPA receptors2018

    • Author(s)
      Yukio Ago, Wataru Tanabe, Momoko Higuchi, Shinji Tsukada, Kenji Hashimoto, Hitoshi Hashimoto
    • Organizer
      The 57th Annual Meeting of American College of Neuropsychopharmacology (ACNP)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] PACAP-provoked PAC1 receptor signaling and internalization through two isoform of β-arrestins dependent mechanisms2018

    • Author(s)
      Yusuke Shintani, Atsuko Hayata-Takano1, Keita Moriguchi and Hitoshi Hashimoto
    • Organizer
      International GPCR Symposium
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] iPS細胞関連技術を用いた統合失調症の分子病態解析および神経細胞分化の基盤技術開発2018

    • Author(s)
      中澤敬信、橋本亮太、田熊一敞、橋本均
    • Organizer
      日本薬学会 第138回年会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 神経薬理研究の最前線2018

    • Author(s)
      橋本均
    • Organizer
      平成29年度 大阪大学薬友会 第8回卒後研修会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 自閉スペクトラム症患者に高頻度でde novo変異が認められる遺伝子産物の機能解析2017

    • Author(s)
      馬場優志、松村憲佑、中澤敬信、永安一樹、笠井淳司、田熊一敞、橋本均
    • Organizer
      第130回 日本薬理学会近畿部会
    • Related Report
      2017 Research-status Report
  • [Presentation] POGZ, a recurrently mutated gene in patients with ASD, regulates the neuronal differentiation2017

    • Author(s)
      Matsumura K, Nakazawa T, Nagayasu K, Miura H, Kasai A, Takuma K, Yamamori H, Yasuda Y, Hashimoto R, Hashimoto H
    • Organizer
      第40回 日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 複数の自閉症患者にde novo変異が認められるPRKD2遺伝子産物の機能解析2017

    • Author(s)
      馬場優志、松村憲佑、中澤敬信、永安一樹、笠井淳司、田熊一敞、橋本均
    • Organizer
      第131回 日本薬理学会近畿部会
    • Related Report
      2017 Research-status Report
  • [Presentation] 自閉スペクトラム症に高頻度に認めるPOGZ遺伝子座の患者特異的de novo変異の表現型解析2017

    • Author(s)
      中澤敬信、田熊一敞、橋本亮太、橋本均
    • Organizer
      第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 全脳マッピングと神経活動操作による情動行動制御機構の解明2017

    • Author(s)
      笠井淳司、丹生光咲、勢力薫、五十嵐久人、桑木崇宏、田沼将人、中澤敬信、山口瞬、山中章弘、橋本均
    • Organizer
      第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
    • Related Report
      2017 Research-status Report
  • [Presentation] Whole-brain mapping analysis of the NMDAR antagonist-induced neuronal activation.2017

    • Author(s)
      Seiriki K, Kasai A, Hashimoto T, Kuwaki T, Niu M, Naka Y, Igarashi H, Nakazawa T, Yamaguchi S, Ago Y, Hashimoto H
    • Organizer
      Neuroscience 2017, Annual Meeting of Society for Neuroscience, USA
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] High-speed serial-sectioning imaging for whole brain analysis with high scalability.2017

    • Author(s)
      Kasai A, Seiriki S, Hashimoto T, Niu M, Yamaguchi S, Naka Y, Igarashi H, Tanuma M, Nakazawa T, Inoue K-I, Takada M, Fujita K, Hashimoto H
    • Organizer
      Neuroscience 2017, Annual Meeting of Society for Neuroscience, USA
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 高頻度にde novo変異が認められる自閉スペクトラム症関連遺伝子POGZの患者由来iPS細胞を用いた分子病態解析2017

    • Author(s)
      岡田翔大、松村憲佑、中澤敬信、永安一樹、馬場優志、笠井淳司、吾郷由希夫、田熊一敞、山森英長、安田由華、橋本亮太、橋本均
    • Organizer
      第132回 日本薬理学会近畿部会
    • Related Report
      2017 Research-status Report
  • [Presentation] ヒトiPS細胞からセロトニン神経細胞への分化誘導法の開発2017

    • Author(s)
      桝中このみ、永安一樹、中澤敬信、吾郷由希夫、田熊一敞、橋本均
    • Organizer
      第132回 日本薬理学会近畿部会
    • Related Report
      2017 Research-status Report
  • [Book] Medical Science Digest 2019年 6月臨時増刊号2019

    • Author(s)
      勢力薫、笠井淳司、橋本均
    • Total Pages
      66
    • Publisher
      ニューサイエンス社
    • Related Report
      2019 Annual Research Report
  • [Remarks] 大阪大学大学院薬学研究科神経薬理学分野ホームページ

    • URL

      http://molpharm.umin.jp/

    • Related Report
      2019 Annual Research Report 2018 Research-status Report 2017 Research-status Report

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Published: 2017-07-21   Modified: 2021-02-19  

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