• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of novel strategy for pancreatic cancer with ultrasound sensitive nanomedicine

Research Project

Project/Area Number 17K19501
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Pharmaceutical Sciences and related fields
Research InstitutionTeikyo University

Principal Investigator

SUZUKI RYO  帝京大学, 薬学部, 教授 (90384784)

Project Period (FY) 2017-06-30 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords薬物送達学 / 超音波 / マイクロバブル / 抗がん剤 / 膵臓がん / リポソーム / ドラッグデリバリーシステム / がん治療 / 薬物送達 / 癌
Outline of Final Research Achievements

Most of anti-cancer drugs have not provided enough therapeutic effects for pancreatic cancer. Thus, it is necessary to develop a novel drug delivery system. In this study, we attempted to develop the doxorubicin encapsulated liposome-loaded on microbubbles (D-lipo-MBs). When D-lipo-MBs were exposed to ultrasound, the collapse of MB would induce the release of the liposomes from MB, and deliver the drug into tumor tissue. Actually, in this delivery system, we observed the effective tumor cell growth suppression because of effective drug delivery by ultrasound exposure. Therefore, this drug delivery system may be a useful drug delivery system for pancreatic cancer.

Academic Significance and Societal Importance of the Research Achievements

膵臓がんに対する画期的な治療法はこれまでになく、新たな治療法の確立が望まれている。したがって、抗がん剤内封リポソームを搭載したマイクロバブルと超音波を応用した本研究は膵臓がんに対する新たな治療戦略を提示するための挑戦的な研究と位置付けられる。本研究で得られた成果は、難治性である膵臓がんの治療に画期的な知見を与えるものと考えている。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (5 results)

All 2020 2019 2018 Other

All Presentation (3 results) (of which Int'l Joint Research: 1 results) Remarks (2 results)

  • [Presentation] 抗がん剤内封リポソーム搭載マイクロバブルと超音波を併用した能動的抗がん剤デリバリーシステムの開発2020

    • Author(s)
      鈴木悠乃, 小俣大樹, 宗像理紗, 島 忠光, 影山彩織, 萩原芙美子, 丸山一雄, 鈴木 亮
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of new anticancer drug delivery system with ultrasound for cancer therapy2019

    • Author(s)
      Yuno Suzuki, Daiki Omata, Lisa Munakata, Tadamitsu Shima, Saori Kageyama, Fumiko Hagiwara, Kazuo Maruyama, Ryo Suzuki
    • Organizer
      The 6th International Symposium on Bioimaging & The 28th Annual Meeting of the Bioimaging Society
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 効率的なリポソームデリバリーをねらった超音波治療システムの構築に関する基礎的検討2018

    • Author(s)
      鈴木悠乃、鈴木亮、小俣大樹、Johan Unga、宗像理紗、影山彩織、Mostafa Soleyman、丸山一雄
    • Organizer
      第62回日本薬学会関東支部大会
    • Related Report
      2018 Research-status Report
  • [Remarks] 帝京大学薬学部薬物送達学研究室

    • URL

      https://www.teikyo-dds.com/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 帝京大学 薬学部 薬物送達学研究室

    • URL

      https://www.teikyo-dds-lab.com/

    • Related Report
      2018 Research-status Report

URL: 

Published: 2017-07-21   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi