Regeneration of elastic fibers
| Project/Area Number |
17K19534
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical structure and function and related fields
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Research Collaborator |
AKAMA Tomoya
KAGESHIMA Masami
SHIMIZU Tadamichi
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| Project Period (FY) |
2017-06-30 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 細胞外マトリックス / 弾性線維 / 再生 / 老化 / 生体分子 / 再生医学 |
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| Outline of Final Research Achievements |
Tissue elasticity in organs such as skin, arteries, and lungs is conferred by an extracellular matrix named elastic fiber. Aging-associated deterioration of elastic fibers causes loose skin, arteriosclerosis, and emphysema, while elastic fibers do not regenerate in aged tissues. In this study, we explored the reason why elastic fiber regeneration does not occur by analyzing the expression of Fibulin-4 and 5, and LTBP-2 and 4, which we have identified as elastogenic proteins, in aged tissues. We also developed an in vitro assay system for elastogenesis.
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| Academic Significance and Societal Importance of the Research Achievements |
老化に伴って私達の体は伸縮性を失ってゆく。皮膚はたるみ、動脈は硬くなり、肺が縮みにくくなって呼吸機能が低下する。これらは、伸縮性を担う弾性線維が劣化・断裂していくことに起因する。弾性線維のターンオーバーは極めて遅く、成長期を過ぎると弾性線維は再生されないとされる。本研究では、なぜ弾性線維が再生されないのか、その理由の一端を明らかにし、弾性線維再生に必要な基盤的知識を提供する。
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Role of thrombospondin-1 in mechanotransduction and development of thoracic aortic aneurysm in mouse and humans.2018
Author(s)
Yamashiro Y, Thang BQ, Shin SJ, Lino CA, Nakamura T, Kim J, Sugiyama K, Tokunaga C, Sakamoto H, Osaka M, Davis EC, Wagenseil JE, Hiramatsu Y and Yanagisawa H.
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Journal Title
Circulation Research
Volume: 123(6)
Issue: 6
Pages: 660-672
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Role of LTBP-4 in alveolarization, angiogenesis and fibrosis in lungs.2017
Author(s)
Bultmann-Mellin I, Dinger K, Debuschewitz C, Loewe KMA, Melcher Y, Plum MTW, Appel S, Rappl G, Willenborg S, Schauss AC, Jungst C, Kruger M, Dressler S, Nakamura T, Wempe F, Alejandre Alcazar MA, Sterner-Kock A
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Journal Title
Am J Physiol Lung Cell Mol Physiol
Volume: 313
Issue: 4
Pages: L687-L698
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart by Preserving Lipid Raft Cholesterol.2016
Author(s)
Nishiga M, Horie T, Kuwabara Y, Nagao K, Baba O, Nakao T, Nishino T, Hakuno D, Nakashima Y, Nishi H, Nakazeki F, Ide Y, Koyama S, Kimura M, Hanada R, Nakamura T, Inada T, Hasegawa K, Conway SJ, Kita T, Kimura T, Ono K.
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Journal Title
Circ Res.
Volume: -
Issue: 5
Pages: 835-847
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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