Identification of microRNA as a serum biomarker for regulatory T cell in CRC cases.

• Project/Area Number: 17K19608
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology and related fields
• Research Institution: Kyushu University
• Principal Investigator: Mimori Koshi 九州大学, 大学病院, 教授 (50322748)
• Project Period (FY): 2017-06-30 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: Treg / FOXP3 / microRNA / FrⅠ+Ⅲ / EZH2 / miEAA / 大腸癌 / 制御性T細胞 / バイオマーカー

Outline of Final Research Achievements

We began a research work to establish the novel chronologic and objective system for evaluating tumor immune response mediated through regulatory T cell (Treg) in local tumor tissues and peripheral blood in colorectal cancer cases. In the current study, we have been disclosing the biological and clinical significance of miRNAs related to Treg among bunch of tissue infiltering lymphocytes (TILs). At present (April 2019), we have collected tissue samples and blood samples from 14 cases. Sample of TIL fraction in multi-region were extracted from case #1-11, and serum and PBMC samples were collected from case #10-14. According to microRNA array in TIL, we are now focusing on and analyzing miRNA inhibiting EZH2 genes which consists of SWI/SNF complex to regulate chromatin remodeling in malignant tissues. Then, we will proceed an enrichment analysis by using of miEAA, an online tool.

Academic Significance and Societal Importance of the Research Achievements

癌は多様性のために難治であるが、免疫チェックポイント阻害剤(ICB)の登場により腫瘍免疫応答の賦活化により多様性を克服するという画期的な治療戦略が生まれた。しかし実臨床では解決するべき課題は多く、特にeffector T-regによるCTLの抑制機構の解明は重要である。このeffector T-regの賦活化を制御する機構を解明し、そのマーカーとなるmiRNAを明らかにすることは学術的意義が大きく、またICB剤のさらなる抗腫瘍効果の改善にも寄与することへの期待は社会的意義も大きい。

Research Products

• [Journal Article] Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis (2019)
  • Author(s): Muto Yoshiharu*、Moroishi Toshiro*、Ichihara Kazuya、Nishiyama Masaaki、Shimizu Hideyuki、Eguchi Hidetoshi、Moriya Kyoji、Koike Kazuhiko、Mimori Koshi、Mori Masaki、Katayama Yuta、Nakayama Keiichi I. (*Equal contribution)
  • Journal Title: The Journal of Experimental Medicine Volume: 216 Issue: 4 Pages: 950-965
  • DOI: 10.1084/jem.20180900
  • Peer Reviewed / Open Access
• [Journal Article] A clinical trial of somatic and germline analyses for healthy longevity in a postoperative cancer patient. (2019)
  • Author(s): Hayashi N, Kuroda Y, Saito T, Tsuruda Y, Niida A, Otsu H, Eguchi H, Masuda T, Suzuki Y, Natsugoe S, Mimori K.
  • Journal Title: Surg Today. Volume: Epub Issue: 9 Pages: 738-747
  • DOI: 10.1007/s00595-019-01789-7
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin‐fixed paraffin‐embedded specimens (2019)
  • Author(s): Kohsaka Shinji、Tatsuno Kenji、Ueno Toshihide、et al.
  • Journal Title: Cancer Science Volume: 110 Issue: 4 Pages: 1464-1479
  • DOI: 10.1111/cas.13968
  • Peer Reviewed / Open Access
• [Journal Article] Plastin3 is associated with epithelial-mesenchymal transition and poor prognosis in gastric cancer. (2019)
  • Author(s): Kurashige J, Yokobori T, Mima K, Sawada G, Takahashi Y, Ueo H, Takano Y, Matsumura T, Uchi R, Eguchi H, Sudo T, Sugimachi K, Mori M, Baba H, Mimori K.
  • Journal Title: Oncol Lett Volume: 17(2) Pages: 2393-2399
  • DOI: 10.3892/ol.2018.9819
  • Peer Reviewed / Open Access
• [Journal Article] Age-related remodelling of oesophageal epithelia by mutated cancer drivers. (2019)
  • Author(s): Yokoyama A, Ogawa S., et al.
  • Journal Title: Nature Volume: 565 Issue: 7739 Pages: 312-317
  • DOI: 10.1038/s41586-018-0811-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CRMP5-associated GTPase (CRAG) Is a Candidate Driver Gene for Colorectal Cancer Carcinogenesis. (2019)
  • Author(s): Shimizu D, Masuda T, Sato K, Tsuruda Y, Otsu H, Kuroda Y, Eguchi H, Kodera Y, Mimori K.
  • Journal Title: Anticancer Res. Volume: 39(1) Issue: 1 Pages: 99-106
  • DOI: 10.21873/anticanres.13084
  • Peer Reviewed / Open Access
• [Journal Article] Multiregion Genomic Analysis of Serially Transplanted Patient-derived Xenograft Tumors. (2019)
  • Author(s): Sato K, Niida A, Masuda T, Shimizu D, Tobo T, Kuroda Y, Eguchi H, Nakagawa T, Suzuki Y, Mimori K.
  • Journal Title: Cancer Genomics Proteomics. Volume: 16(1) Issue: 1 Pages: 21-27
  • DOI: 10.21873/cgp.20109
  • Peer Reviewed / Open Access
• [Journal Article] Cytolytic Activity (CYT) Score Is a Prognostic Biomarker Reflecting Host Immune Status in Hepatocellular Carcinoma (HCC). (2018)
  • Author(s): Wakiyama H, Masuda T, Motomura Y, Hu Q, Tobo T, Eguchi H, Sakamoto K, Hirakawa M, Honda H, Mimori K.
  • Journal Title: Anticancer Res Volume: 38(12) Issue: 12 Pages: 6631-6638
  • DOI: 10.21873/anticanres.13030
  • Peer Reviewed / Open Access
• [Journal Article] Cancer evolution and heterogeneity (2018)
  • Author(s): Mimori K, Saito T, Niida A, Miyano S
  • Journal Title: Ann Gastroenterol Surg Volume: 2(5) Issue: 5 Pages: 332-338
  • DOI: 10.1002/ags3.12182
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Impact of Immune-Related Gene Expression in Preoperative Peripheral Blood from Gastric Cancer Patients (2018)
  • Author(s): Shuhei Ito et al
  • Journal Title: Ann Surg Oncol Volume: 25 Issue: 12 Pages: 3755
  • DOI: 10.1245/s10434-018-6739-4
  • Peer Reviewed / Open Access
• [Journal Article] Serial mutational tracking in surgically resected locally advanced colorectal cancer with neoadjuvant chemotherapy. (2018)
  • Author(s): Sugimachi K, Sakimura S, Kuramitsu S, Hirata H, Niida A, Iguchi T, Eguchi H, Masuda T, Morita M, Toh Y, Maehara Y, Suzuki Y, Mimori K.
  • Journal Title: Br J Cancer. Volume: 4 Issue: 4 Pages: 419-423
  • DOI: 10.1038/s41416-018-0208-5
  • Peer Reviewed / Open Access
• [Journal Article] Circulating Pre-microRNA-488 in Peripheral Blood Is a Potential Biomarker for Predicting Recurrence in Breast Cancer. (2018)
  • Author(s): Masuda T, Shinden Y, Noda M, Ueo H, Hu Q, Yoshikawa Y, Tsuruda Y, Kuroda Y, Ito S, Eguchi H, Ohno S, Mimori K.
  • Journal Title: Anticancer Res. Volume: 38(8) Issue: 8 Pages: 4515-4523
  • DOI: 10.21873/anticanres.12755
  • Peer Reviewed / Open Access
• [Journal Article] A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer (2018)
  • Author(s): Saito T, Niida A, Uchi R, Hirata H, Kodama M, Okimoto T, Murakami K, Suzuki Y, Ogawa S, Miyano S, Mimori K, et al.
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 2884-2884
  • DOI: 10.1038/s41467-018-05226-0
  • NAID: 120006551763
  • Peer Reviewed / Open Access
• [Journal Article] Over expression of FGFR1 Promotes Peritoneal Dissemination Via Epithelial-to-Mesenchymal Transition in Gastric Cancer. (2018)
  • Author(s): Shimizu D, Saito T, Ito S, Masuda T, Kurashige J, Kuroda Y, Eguchi H, Kodera Y, Mimori K.
  • Journal Title: Cancer Genomics Proteomics. Volume: 15(4) Issue: 4 Pages: 313-320
  • DOI: 10.21873/cgp.20089
  • Peer Reviewed / Open Access
• [Journal Article] Identification of UHRF2 as a Negative Regulator of Epithelial-Mesenchymal Transition and Its Clinical Significance in Esophageal Squamous Cell Carcinoma. (2018)
  • Author(s): Iguchi T, Ueda M, Masuda T, Nambara S, Kidogami S, Komatsu H, Sato K, Tobo T, Ogawa Y, Hu Q, Saito T, Hirata H, Sakimura S, Uchi R, Hayashi N, Ito S, Eguchi H, Sugimachi K, Maehara Y, Mimori K
  • Journal Title: Oncology Volume: 3 Issue: 3 Pages: 179-187
  • DOI: 10.1159/000488860
  • Peer Reviewed / Open Access
• [Journal Article] PLOD2 as a potential regulator of peritoneal dissemination in gastric cancer. (2018)
  • Author(s): Kiyozumi Y, Iwatsuki M, Kurashige J, Ogata Y, Yamashita K, Koga Y, Toihata T, Hiyoshi Y, Ishimoto T, Baba Y, Miyamoto Y, Yoshida N, Yanagihara K, Mimori K, Baba H.
  • Journal Title: Int J Cancer. Volume: Mar 30 Issue: 5 Pages: 1202-1211
  • DOI: 10.1002/ijc.31410
  • Peer Reviewed / Open Access
• [Journal Article] GWAS Identifies Two Novel Colorectal Cancer Loci at 16q24.1 and 20q13.12. (2018)
  • Author(s): Tanikawa C, Kamatani Y, Takahashi A, Momozawa Y, Leveque K, Nagayama , Mimori K, Mori M, Ishii H, Inazawa J, Yasuda J, Tsuboi A, Shimizu A, Sasaki M, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Naito M, Wakai K, Koyama T, Takezaki T, Yuji K, Murakami Y, Nakamura Y, Kubo M, Matsuda K
  • Journal Title: Carcinogenesis Volume: Epub Issue: 5 Pages: 652-660
  • DOI: 10.1093/carcin/bgy026
  • Peer Reviewed / Open Access
• [Journal Article] Understanding intratumor heterogeneity by combining genome analysis and mathematical modeling (2018)
  • Author(s): Niida Atsushi、Nagayama Satoshi、Miyano Satoru、Mimori Koshi
  • Journal Title: Cancer science Volume: 109 Issue: 4 Pages: 884-892
  • DOI: 10.1111/cas.13510
  • Peer Reviewed / Open Access
• [Journal Article] Combined mutation of Apc, Kras and Tgfbr2 effectively drives metastasis of intestinal cancer. (2018)
  • Author(s): Sakai E, Nakayama M, Oshima H, Kouyama Y, Niida A, Fujii S, Ochiai A, Nakayama KI, Minori K, Suzuki Y, Hong CP, Ock CY, Kim SJ, Oshima M.
  • Journal Title: Cancer Res. Volume: 78 Issue: 5 Pages: 1334-1346
  • DOI: 10.1158/0008-5472.can-17-3303
  • NAID: 120006452378
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification of ARL4C as a Peritoneal Dissemination-Associated Gene and Its Clinical Significance in Gastric Cancer. (2018)
  • Author(s): Hu Q, Masuda T, Sato K, Tobo T, Nambara S, Kidogami S, Hayashi N, Kuroda Y, Ito S, Eguchi H, Saeki H, Oki E, Maehara Y, Mimori K
  • Journal Title: Ann Surg Oncol Volume: 25(3) Issue: 3 Pages: 745-753
  • DOI: 10.1245/s10434-017-6292-6
  • Peer Reviewed / Open Access
• [Journal Article] Antitumor effects of the antiparasitic agent ivermectin via inhibition of Yes-associated protein 1 expression in gastric cancer. (2017)
  • Author(s): Nambara S, Masuda T, Nishio M, Kuramitsu S, Tobo T, Ogawa Y, Hu Q, Iguchi T, Kuroda Y, Ito S, Eguchi H, Sugimachi K, Saeki H, Oki E, Maehara Y, Suzuki A, Mimori K
  • Journal Title: Oncotarget. Volume: 8(64) Issue: 64 Pages: 107666-107677
  • DOI: 10.18632/oncotarget.22587
  • NAID: 120006454566
  • Peer Reviewed / Open Access
• [Journal Article] Circulating exosomal microRNA-203 is associated with metastasis possibly via inducing tumor-associated macrophages in colorectal cancer (2017)
  • Author(s): Takano Y, Masuda T, Iinuma H, Yamaguchi R, Sato K, Tobo T, Hirata H, Kuroda Y, Nambara S, Hayashi N, Iguchi T, Ito S, Eguchi H, Ochiya T, Yanaga K, Miyano S, Mimori K
  • Journal Title: Oncotarget Volume: 8(45) Issue: 45 Pages: 78598-78613
  • DOI: 10.18632/oncotarget.20009
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] MicroRNAs as Biomarkers in Colorectal Cancer. (2017)
  • Author(s): Masuda T, Hayashi N, Kuroda Y, Ito S, Eguchi H, Mimori K
  • Journal Title: Cancers (Basel). Volume: 9(9) Issue: 9 Pages: 124-124
  • DOI: 10.3390/cancers9090124
  • Peer Reviewed / Open Access
• [Journal Article] Japanese genome-wide association study identifies a significant colorectal cancer susceptibility locus at chromosome 10p14. (2017)
  • Author(s): Takahashi Y, Sugimachi K, Yamamoto K, Niida A, Shimamura T, Sato T, Watanabe M, Tanaka J, Kudo S, Sugihara K, Hase K, Kusunoki M, Yamada K, Shimada Y, Moriya Y, Suzuki Y, Miyano S, Mori M, Mimori K
  • Journal Title: Cancer Sci. Volume: 108(11) Issue: 11 Pages: 2239-2247
  • DOI: 10.1111/cas.13391
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical significance of ZNF750 gene expression, a novel tumor suppressor gene, in esophageal squamous cell carcinoma. (2017)
  • Author(s): Nambara S, Masuda T, Tobo T, Kidogami S, Komatsu H, Sugimachi K, Saeki H, Oki E, Maehara Y,Mimori K
  • Journal Title: Oncol Lett Volume: 14(2) Issue: 2 Pages: 1795-1801
  • DOI: 10.3892/ol.2017.6341
  • Peer Reviewed / Open Access
• [Journal Article] Significance of CD47 expression in gastric cancer (2017)
  • Author(s): Sudo Tomoya、Takahashi Yusuke、Sawada Genta、Uchi Ryutaro、Mimori Koshi、Akagi Yoshito
  • Journal Title: Oncology Letters Volume: 14 Issue: 1 Pages: 801-809
  • DOI: 10.3892/ol.2017.6257
  • Peer Reviewed / Open Access
• [Journal Article] DDR2 Expression Is Associated with a High Frequency of Peritoneal Dissemination and Poor Prognosis in Colorectal Cancer (2017)
  • Author(s): Sasaki S, Ueda M, Iguchi T, Kaneko M, Nakayama H, Watanabe T, Sakamoto A, Mimori K
  • Journal Title: Anticancer Res Volume: 37(5) Pages: 2587-2591
  • Peer Reviewed
• [Journal Article] Phosphoserine Phosphatase Is a Novel Prognostic Biomarker on Chromosome 7 in Colorectal Cancer. (2017)
  • Author(s): Sato K, Masuda T, Hu Q, Tobo T, Kidogami S, Ogawa Y, Saito T, Nambara S, Komatsu H, Hirata H, Sakimura S, Uchi R, Hayashi N, Iguchi T, Eguchi H, Ito S, Nakagawa T, Mimori K
  • Journal Title: Anticancer Res. Volume: 37(5) Pages: 2365-2371
  • Peer Reviewed
• [Journal Article] Up-regulation of SLC9A9 Promotes Cancer Progression and Is Involved in Poor Prognosis in Colorectal Cancer. (2017)
  • Author(s): Ueda M, Iguchi T, Masuda T, Komatsu H, Nambara S, Sakimura S, Hirata H, Uchi R, Eguchi H, Ito S, Sugimachi K, Mizushima T, Doki Y, Mori M, Mimori K
  • Journal Title: Anticancer Res. Volume: 37(5) Pages: 2255-2263
  • Peer Reviewed
• [Journal Article] phyC: Clustering cancer evolutionary trees. (2017)
  • Author(s): Matsui Y, Niida A, Uchi R, Mimori K, Miyano S, Shimamura T:
  • Journal Title: PLoS Comput Biol. Volume: 13(5) Issue: 5 Pages: 1005509-1005509
  • DOI: 10.1371/journal.pcbi.1005509
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Overexpression of heat-shock factor 1 is associated with a poor prognosis in esophageal squamous cell carcinoma. (2017)
  • Author(s): Tsukao Y, Yamasaki M, Miyazaki Y, Makino T, Takahashi T, Kurokawa Y, Miyata H, Nakajima K, Takiguchi S, Mimori K, Mori M, Doki Y:
  • Journal Title: Oncol Lett. Volume: 13(3) Issue: 3 Pages: 1819-1825
  • DOI: 10.3892/ol.2017.5637
  • Peer Reviewed / Open Access
• [Journal Article] The loss of CASP4 expression is associated with poor prognosis in esophageal squamous cell carcinoma (2017)
  • Author(s): Shibamoto M, Hirata H, Eguchi H, Sawada G, Sakai N, Kajiyama Y, Mimori K
  • Journal Title: Oncology Letters Volume: 13 Issue: 3 Pages: 1761-6
  • DOI: 10.3892/ol.2017.5646
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Altered expression of Hippo signaling pathway molecules in intrahepatic cholangiocarcinoma. (2017)
  • Author(s): Sugimachi K, Nishio M, Aishima S, Kuroda Y, Iguchi T, Komatsu H, Hirata H, Sakimura S, Eguchi H, Bekki Y, Takenaka K, Maehara Y, Suzuki A, Mimori K.
  • Journal Title: ONCOLOGY Volume: - Issue: 1 Pages: 67-74
  • DOI: 10.1159/000463390
  • Peer Reviewed / Open Access
• [Journal Article] Extraction of cell-free DNA from urine, using polylysine-coated silica particles. (2017)
  • Author(s): Takano S, Hu Q, Amamoto T, Refinetti P, Mimori K, Funatsu T, Kato M
  • Journal Title: Anal Bioanal Chem. Volume: 409(16) Issue: 16 Pages: 4021-4025
  • DOI: 10.1007/s00216-017-0345-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation. Oncogene (2017)
  • Author(s): Otsubo K, Goto H, Nishio M, Kawamura K, Yanagi S, Nishie W, Sasaki T, Maehama T, Nishina H, Mimori K, Nakano T, Shimizu H, Mak TW, Nakao K, Nakanishi Y, Suzuki A
  • Journal Title: Oncogene Volume: 印刷中 Issue: 29 Pages: 4201-4211
  • DOI: 10.1038/onc.2017.58
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Clinical Significance of FANCD2 Gene Expression and its Association with Tumor Progression in Hepatocellular Carcinoma. (2017)
  • Author(s): Komatsu H, Masuda T, Iguchi T, Nambara S, Sato K, Hu Q, Hirata H, Ito S, Eguchi H, Sugimachi K, Eguchi H, Doki Y, Mori M, Mimori K
  • Journal Title: Anticancer Res. Volume: 37(3) Pages: 1083-1090
  • Peer Reviewed
• [Journal Article] Clinical Impact of Tumor-Infiltrating Lymphocytes in Esophageal Squamous Cell Carcinoma. (2017)
  • Author(s): Sudo T, Nishida R, Kawahara A, Saisho K, Mimori K, Yamada A, Mizoguchi A, Kadoya K, Matono S, Mori N, Tanaka T, Akagi Y.
  • Journal Title: Ann Surg Oncol. Volume: in press Issue: 12 Pages: 3763-3770
  • DOI: 10.1245/s10434-017-5796-4
  • Peer Reviewed / Open Access
• [Journal Article] Downregulation of ST6GALNAC1 is associated with esophageal squamous cell carcinoma development. (2017)
  • Author(s): Iwaya T, Sawada G, Amano S, Kume K, Ito C, Endo F, Konosu M, Shioi Y, Akiyama Y, Takahara T, Otsuka K, Nitta H, Koeda K, Mizuno M, Nishizuka S, Sasaki A, Mimori K.
  • Journal Title: Int J Oncol. Volume: 50(2) Issue: 2 Pages: 441-447
  • DOI: 10.3892/ijo.2016.3817
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Expression of CCAT2, a Novel Long Noncoding RNA Transcript, and rs6983267 Single-Nucleotide Polymorphism Genotypes in Colorectal Cancers. (2017)
  • Author(s): Kasagi Y, Oki E, Ando K, Ito S, Iguchi T, Sugiyama M, Nakashima Y, Ohgaki K, Saeki H, Mimori K, Maehara Y:
  • Journal Title: Oncology. Volume: 92(1) Issue: 1 Pages: 48-54
  • DOI: 10.1159/000452143
  • Peer Reviewed / Open Access
• [Journal Article] Overexpression of CXCR7 Is a Novel Prognostic Indicator in Gastric Cancer. (2016)
  • Author(s): Nambara S, Iguchi T, Oki E, Tan P, Maehara Y, Mimori K.
  • Journal Title: Dig Surg Volume: Epub Issue: 4 Pages: 312-318
  • DOI: 10.1159/000452977
  • Peer Reviewed / Open Access
• [Journal Article] Attenuated RND1 Expression Confers Malignant Phenotype and Predicts Poor Prognosis in Hepatocellular Carcinoma (2016)
  • Author(s): Komatsu H, Iguchi T, Masuda T, Hirata H, Ueda M, Kidogami S, Ogawa Y, Sato K, Hu Q, Nambara S, Saito T, Sakimura S, Uchi R, Ito S, Eguchi H, Sugimachi K, Eguchi H, Doki Y, Mori M, Mimori K.
  • Journal Title: Ann Surg Oncol. Volume: 24(3) Issue: 3 Pages: 850-859
  • DOI: 10.1245/s10434-016-5573-9
  • Peer Reviewed / Open Access
• [Journal Article] As a Novel Prognostic Marker, Cysteine/histidine-rich 1 (CYHR1) is a Therapeutic Target in Patients with Esophageal Squamous Cell Carcinoma. (2015)
  • Author(s): Desaki R, Sawada G, Okumura H, Ikeda R, Tanabe K, Komatsu H, Mimori K, Mori M, Kita Y, Uchikado Y, Arigami T, Uenosono Y, Owaki T, Ishigami S, Natsugoe S.
  • Journal Title: Ann Surg Oncol. Volume: Epub Issue: 2 Pages: 586-593
  • DOI: 10.1245/s10434-015-5031-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 大腸癌の進展におけるmicroRNA-203（miR-203）の局在依存的な相反する機能 (2018)
  • Author(s): 増田隆明、高野裕樹、飯沼久恵、倉光正太郎、藤井昌志、北川彰洋、清水大、野田美和、吉川幸宏、胡慶江、鶴田祐介、黒田陽介、江口英利、矢永勝彦、三森功士
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 大腸癌におけるAGAP3の分子生物学的意義の検討 (2018)
  • Author(s): 清水大、佐藤晋彰、伊藤修平、増田隆明、北川彰洋、倉光正太郎、添田祐治、藤井昌志、神山勇太、野田美和、吉川幸宏、脇山浩明、胡慶江、齋藤衆子、鶴田祐介、黒田陽介、江口英利、小寺泰弘、三森功士
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 大腸がんにおける術源術後の経時的血清中microRNAの臨床的有用性について (2018)
  • Author(s): 吉川幸宏、福永光子、増田隆明、伊藤修平、清水大、倉光正太郎、藤井昌志、北川彰洋、野田美和、胡慶江、鶴田祐介、黒田陽介、江口英利、山田一隆、土岐祐一郎、森正樹、三森功士
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 7番染色体短腕（7p）に存在する大腸癌の新規ドライバー遺伝子DDX56の同定 (2018)
  • Author(s): 鶴田祐介、神山勇太、増田隆明、小川悠史、佐藤晋彰、胡慶江、野田美和、吉川幸宏、北川彰洋、藤井昌志、倉光正太郎、清水大、伊藤修平、江口英利、黒田陽介、三森功士
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 陥凹型早期大腸癌の遺伝子学的特徴 (2018)
  • Author(s): 江口英利、北川彰洋、倉光正太郎、清水大、藤井昌志、野田美和、吉川幸宏、胡慶江、鶴田祐介、黒田陽介、増田隆明、伊藤修平、三森功士
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] Circulating exosomal miR-203 is associated with metastasis via inducing tumor-associated macrophages in colorectal cancer (2018)
  • Author(s): D Shimizu, T Masuda, Y Takano, H Iinuma, R Yamaguchi, K Sato, T Tobo, H Hirata, Y Kuroda, S Nambara, N Hayashi, T Iguchi, S Ito, H Eguchi, T Ochiya, K Yanaga, S Miyano, K Mimori.
  • Organizer: AACR Annual Meeting 2018
  • Int'l Joint Research
• [Presentation] がんゲノム進化の解明と臨床応用にむけてのアプローチ (2018)
  • Author(s): 三森功士
  • Organizer: 第117回北海道癌談話会 春期シンポジウム
  • Invited
• [Presentation] 大腸がんにおいて転移を決める条件について (2018)
  • Author(s): 北川彰洋、黒田陽介、鶴田祐介、大津甫、江口英利、増田隆明、三森功士
  • Organizer: 第230回大分県外科医会
• [Presentation] がん進化論からみた腫瘍免疫療法の有効性についての考察 (2018)
  • Author(s): 三森功士
  • Organizer: 第73回日本消化器外科学会総会
• [Presentation] 陥凹型早期大腸癌における網羅的遺伝子解析の検討 (2018)
  • Author(s): 江口英利、清水大、倉光正太郎、吉川幸宏、胡慶江、鶴田祐介、黒田陽介、増田隆明、伊藤修平、三森功士
  • Organizer: 第73回日本消化器外科学会総会
• [Presentation] 7番染色体短腕（7p）に存在する大腸癌の新規ドライバー遺伝子DEAD Box Helicase56(DDX56)の同定 (2018)
  • Author(s): 増田隆明、倉光正太郎、藤井昌志、北川彰洋、胡慶江、鶴田祐介、黒田陽介、伊藤修平、江口英利、三森功士
  • Organizer: 第73回日本消化器外科学会総会
• [Presentation] 大腸がんにおける経時的血清中microRNAのコンビネーションの臨床的有用性 (2018)
  • Author(s): 吉川幸宏、福永光子、伊藤修平、増田隆明、江口英利、山田一隆、土岐祐一郎、森正樹、三森功士
  • Organizer: 第73回日本消化器外科学会総会
• [Presentation] 新規癌遺伝子oxysterol binding protein like 3(OSBPL3)の大腸癌における臨床的意義 (2018)
  • Author(s): 胡慶江、増田隆明、倉光正太郎、鶴田祐介、黒田陽介、伊藤修平、江口英利、沖英次、前原喜彦、三森功士
  • Organizer: 第73回日本消化器外科学会総会
• [Presentation] 術後再発大腸がん患者においてctDNA変異検出ト腫瘍免疫応答について (2018)
  • Author(s): 三森功士
  • Organizer: 第27回日本がん転移学会学術集会・総会
• [Presentation] 大腸がんにおける経時的血清中microRNAのコンビネーションの臨床的有用性 (2018)
  • Author(s): 吉川幸宏、増田隆明、清水大、大津甫、黒田陽介、江口英利、山田一隆、土岐祐一郎、森正樹、三森功士
  • Organizer: 第77回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] elF5 Mimic Protein 1(5MP1)はMYCの翻訳開始点をリプログラムし大腸癌の悪性化を促進する (2018)
  • Author(s): 佐藤晋彰、増田隆明、胡慶江、齋藤衆子、脇山浩明、吉川幸宏、神山勇太、野田美和、黒田陽介、江口英利、中川尚志、三森功士
  • Organizer: 第77回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] 大腸癌におけるAGAP3の分子生物学的意義の検討 (2018)
  • Author(s): 清水大、齋藤衆子、佐藤晋彰、増田隆明、大津甫、黒田陽介、江口英利、神田光郎、小寺泰弘、三森功士
  • Organizer: 第77回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] 大腸癌におけるoxysterol binding protein like 3(OSBPL3)の臨床的意義 (2018)
  • Author(s): 江口英利、胡慶江、増田隆明、清水大、藤井昌志、野田美和、神山勇太、吉川幸宏、脇山浩明、佐藤晋彰、鶴田祐介、黒田陽介、三森功士
  • Organizer: 第77回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] 大腸癌において7番染色体短腕のDEAD-Box Helicase56の増幅が癌化に影響するスプライシング異常を誘導する (2018)
  • Author(s): 黒田陽介、神山勇太、増田隆明、野田美和、吉川幸宏、佐藤晋彰、清水大、鶴田祐介、大津甫、江口英利、三森功士
  • Organizer: 第77回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] 大腸癌におけるAGAP3の分子生物学的意義の検討 (2018)
  • Author(s): 清水大、佐藤晋彰、増田隆明、大津甫、黒田陽介、江口英利、神田光郎、小寺泰弘、三森功士
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] 大腸発がんから進行がんとなり難治性を呈するまでの新たな大腸がんモデル (2018)
  • Author(s): 三森功士
  • Organizer: 公益財団法人高松宮妃癌研究基金 第49回国際シンポジウム
• [Presentation] 大腸癌における新たながん遺伝子5MP1はMYCの翻訳リプログラミングを介して細胞増殖を促進する (2018)
  • Author(s): 佐藤晋彰、増田隆明、大津甫、鶴田祐介、江口英利、黒田陽介、三森功士
  • Organizer: 第29回日本消化器癌発生学会
• [Presentation] 消化器がんにおける様々な進化機構について～新たな大腸がん進化機構の解明～ (2018)
  • Author(s): 三森功士
  • Organizer: 第44回北里大学医学会総会
  • Invited
• [Presentation] 大腸がんにおける進化機構のシフトによる腫瘍内多様性の創出 (2018)
  • Author(s): 三森功士
  • Organizer: 第14回日本消化管学会総会学術集会
• [Presentation] 大腸がんにおける新たな進化と選択圧について (2018)
  • Author(s): 三森功士
  • Organizer: 第2回消化器外科臨床応用をめざす研究交流会
  • Invited
• [Presentation] 大腸がんにおける新たな進化と多様性創出機構について (2017)
  • Author(s): 三森功士
  • Organizer: Translation Research Seminar
• [Presentation] がん転移再発の早期診断におけるctDNAの臨床的有用性について (2017)
  • Author(s): 三森功士
  • Organizer: JBICバイオ関連基盤技術研究会
• [Presentation] 薬物動態から見直す大腸がん化学療法 (2017)
  • Author(s): 三森功士
  • Organizer: 第28回日本消化器癌発生学会
  • Invited
• [Presentation] 消化器がん転移再発診断と治療評価法に関するctDNA解析の臨床的有用性と今後の課題 (2017)
  • Author(s): 三森功士
  • Organizer: 第55回日本癌治療学会学術集会
• [Presentation] 食道がんゲノム情報に基づく診断と治療戦略の構築 (2017)
  • Author(s): 三森功士
  • Organizer: JDDW2017
• [Presentation] 大腸発がんから進行がんにいたる過程のゲノムレベル進化について (2017)
  • Author(s): 三森功士
  • Organizer: 第3回がんゲノム・エピゲノムセミナー
• [Presentation] ctDNAにおいて突然変異の検出が可能な原発巣の特徴 (2017)
  • Author(s): 三森功士
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 消化器がん症例の様々な臨床的局面における血中ctDNA突然変異検出の意義 (2017)
  • Author(s): 三森功士
  • Organizer: 第26回日本がん転移学会
• [Presentation] 消化器癌におけるctDNA検出の臨床的意義と臨床応用にむけての提言 (2017)
  • Author(s): 三森功士
  • Organizer: 第72回日本消化器外科学会
• [Presentation] プロパゲルマニウム（SK-818）の骨髄由来細胞制御機構による癌転移巣増殖制御について (2017)
  • Author(s): 三森功士
  • Organizer: 第38回日本炎症・再生医学会
  • Invited
• [Presentation] 大腸がんの進化と転移再発を決める選択圧について (2017)
  • Author(s): 三森功士
  • Organizer: 昭和大学横浜北部病院2017年消化器センター軽井沢セミナー
  • Invited
• [Presentation] がん治療における革新的変化を踏まえた最先端技術，新たな開発戦略の現状と今後の方向性 (2017)
  • Author(s): 三森功士
  • Organizer: 第23回抗悪性腫瘍薬開発フォーラム