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Allergy research prospect with new paradigm open up by the new sensitive allergen microarray

Research Project

Project/Area Number 17K19662
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field General internal medicine and related fields
Research InstitutionThe University of Tokushima

Principal Investigator

KIDO Hiroshi  徳島大学, 先端酵素学研究所(デザイン), 特任教授 (50144978)

Research Collaborator TADA Hitomi  
SHINAHARA Wakako  
Project Period (FY) 2017-06-30 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywordsアレルギー / クラススイッチ / 湿疹 / 母乳栄養 / 人工栄養 / IgE / IgG1 / IgG2 / 食物アレルギー / 抗原親和性 / IgM / 経口免疫寛容 / マイクロアレイ / 免疫寛容
Outline of Final Research Achievements

We analyzed immunoglobulin class-switching and allergen-affinity of various immunoglobulin subtypes by the highly sensitive densely carboxylated protein microarray, which we had developed. Eczema during lactation period during the early infancy induced Th2-dependent immunoglobulin class-switching, resulting in high-affinity IgE production and suppression of IgA and IgG2 production, which is developed to food allergy at one year of age. In contrast, infants without eczema or with mild eczema induced Th1-dependent immunoglobulin class-switching through gastrointestinal mucosal allergen sensitization, resulting in low-affinity IgE, IgA and IgG2 production, which is developed to food tolerance at one year of age.

Academic Significance and Societal Importance of the Research Achievements

国民の約30%が何らかのアレルギー疾患に罹患している現状で、アレルギーの予防と治療を担う「アレルギー医療革命」が始まっている。この新たな治療を、安全で確実に実施するための検査方法、発症理論に基づく検査法として、研究者等が開発した高感度のDensely carboxylated protein (DCP) マイクロアレイを用いて、イムノグロブリンクラススイッチ解析と各種抗体の抗原親和性解析から取り組んだ。その結果、食物アレルギー発症児と免疫寛容児の間で、イムノグロブリンクラススイッチ解析とIgE抗体の抗原親和性の大きな違いを見出して、乳児の早期予後診断のバイオマーカーを提案することができた。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (14 results)

All 2019 2018 2017

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (11 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Trajectories of class-switching-related egg and cow’s milk allergen-specific immunoglobulin isotype formation and its modification by eczema with low- and high-affinity immunoglobulin E during early infancy.2019

    • Author(s)
      Irahara M, Shinahara W, Sugimoto M, Ogawa Y, Shitukawa K, Kubota K, Yang L, Saito H, Kagami S, Arisawa K, Kido H
    • Journal Title

      Immun Inflamm Dis

      Volume: 7 Pages: 74-85

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Early aggressive intervention for infantile atopic dermatitis to prevent development of food allergy: a multicenter, investigator-blinded, randomized, parsllel group controlled trial (PACI Study): protocol for a randomized controlled trial.2018

    • Author(s)
      Yamamoto-Hanada K, Kobayashi T, Williams H, Minami M, Abe M, Morita K, Natsume O, Sato M, Iwama M, Miyaji Y, Miyata M, Inagaki S, Tatsuki F, Narita M, Nakayama SF, Kido H, Saito H, Ohya Y
    • Journal Title

      Clin Trans Allergy

      Volume: 8 Issue: 1 Pages: 47-47

    • DOI

      10.1186/s13601-018-0233-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oral immunotherapy combined with omalizumab for high-risk cow's milk allergy: a randomized controlled trial2017

    • Author(s)
      Masaya Takahashi, Kazuhiko Soejima, Shoichiro Taniuchi, Yasuko Hatano, Sohsaku Yamanouchi, Hideki Ishikawa, Makoto Irahara, Youhei Sasaki, Hiroshi Kido, Kazunari Kaneko
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1

    • DOI

      10.1038/s41598-017-16730-6

    • NAID

      120006875671

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 経皮感作食物アレルギーモデルマウスに対する経口ワクチンの治療効果2018

    • Author(s)
      木本貴士、亀田桂子、堺聡子、松本真輝、高橋悦久、長尾みづほ、藤澤隆夫、木戸博
    • Organizer
      第55回日本小児アレルギー学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] カゼイン経皮感作アレルギーモデルマウスの作成と、アレルゲンの経口負荷アナフィラキシー誘発評価系の確立2018

    • Author(s)
      木本貴士、亀田桂子、堺聡子、松本真輝、高橋悦久、長尾みづほ、藤澤隆夫、木戸博
    • Organizer
      第55回日本小児アレルギー学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Different modes of immunoglobulin class-switching from allergen-specific IgG1 to low and high affinity IgE in the development of oral tolerance and food allergy.2018

    • Author(s)
      Kido H, Irahara M, Shinahara W
    • Organizer
      第67回日本アレルギー学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Allergen-specific low- and high-affinity IgE production associated with differential immunoglobulin class-switching in the development of pediatric food allergy in early infancy2018

    • Author(s)
      Hiroshi Kido, Makoto Irahara, Wakako Shinahara
    • Organizer
      AAAAI/WAO Joint Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Differential immunoglobulin class switching in the productions of aller-gen-specific low and high affinity IgE in the development of pediatric food allergy2017

    • Author(s)
      Kido H, Irahara M, Sasaki Y.
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 乳児期におけるイムノグロブリンクラススイッチの進展と抗原親和性2017

    • Author(s)
      苛原誠、佐々木陽平、品原和加子、杉本真弓、香美祥二、木戸博
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 新生児血中特異的IgE抗体と乳児期の感作についての検討2017

    • Author(s)
      渋谷紀子、斎藤恵美子、苛原誠、佐々木陽平、木戸博
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 微量採血による継時的抗原特異的イムノイグロブリンクラススイッチの動物実験モニター法2017

    • Author(s)
      佐々木陽平、大野仁詩、鈴木宏一、木戸博
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 生後6ヶ月までの母乳栄養児と人工乳栄養児の抗原摂取量の違いを背景とした湿疹誘発IgEクラススイッチパターンの違い2017

    • Author(s)
      木戸博、苛原誠、品原和加子、杉本真弓、香美祥二
    • Organizer
      第54回日本小児アレルギー学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 乳児期の経口免疫寛容と食物アレルギー発症の判定に有用なイムノグロブィンクラススイッチパターンの違いとIgEの高抗原親和性、低親和性IgE2017

    • Author(s)
      木戸博、苛原誠、品原和加子、香美祥二
    • Organizer
      第90回日本生化学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 微量採血によるアレルギーモデル実験動物の経時的抗原特異的抗体価の測定系の確立2017

    • Author(s)
      大野仁詩、品原和加子、高橋悦久、木戸博
    • Organizer
      第90回日本生化学会大会
    • Related Report
      2017 Research-status Report

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Published: 2017-07-21   Modified: 2020-03-30  

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