Age-related changes of sleep bruxism pathophysiology
| Project/Area Number |
17K19753
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Oral Science and related fields
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| Research Institution | Osaka University |
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Principal Investigator |
Kato Takafumi 大阪大学, 歯学研究科, 教授 (50367520)
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 文彦 大阪大学, 歯学研究科, 助教 (60632130)
池邉 一典 大阪大学, 歯学研究科, 教授 (70273696)
三上 章良 大阪府立大学, 総合リハビリテーション学研究科, 教授 (60301272)
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| Project Period (FY) |
2017-06-30 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 睡眠時ブラキシズム / 加齢 / 咀嚼筋活 / 顎運動 / 睡眠関連疾患 / 睡眠 / 咀嚼筋 / 顎口腔機能 / ブラキシズム / ポリソムノグラフィー / 口腔機能 |
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| Outline of Final Research Achievements |
The results of the present research project showed the followings. 1) Young, otherwise healthy, SB subjects presented normal physiologic variables in sleep architecture, psychologic and cardiac variables. 2) In comparison to young SB subjects, middle-aged SB subjects showed a low quality in sleep architecture such as an increase of microarousals although the frequency of rhythmic masticatory muscle activity (RMMA) did not differ between the groups. However, middle aged SB subjects showed less frequent teeth grinding than young SB subjects. 3) In animals, RMMA, mimicking RMMA in humans, was found to occur in NREM sleep in experimental animals.
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| Academic Significance and Societal Importance of the Research Achievements |
歯ぎしりのような特殊な運動が睡眠中に生じるために、脳の活性化に加え、顎の運動を調節する神経回路が活動が重要であること、さらに加齢に伴う歯ぎしりの変化は、睡眠よりも顎の運動を調節するしくみの変化による可能性が示唆された点で、学術的な意義がある。また、実験動物が歯ぎしり様の運動を示すことから、歯ぎしりが生じるしくみを科学的に研究する方法に、基礎研究を取り入れるオプションが増えた点で社会的意義がある。ヒトの研究と組み合わせることで、診断法や治療法の開発に向けた研究に寄与すると考えられる。
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Sleep quality, psychological profiles, cardiac activity and salivary biomarkers in young subjects with different degrees of rhythmic masticatory muscle activity: a polysomnography study.2019
Author(s)
Haraki S, Tsujisaka A, Nonoue S, Nochino T, Kamimura M, Adachi H, Ishigaki S, Yatani H, Taniike M, Kato T.
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Journal Title
Journal of Oral & Facial Pain and Headache
Volume: 33
Issue: 1
Pages: 105-113
DOI
Related Report
Peer Reviewed
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[Journal Article] International consensus on the assessment of bruxism: Report of a work in progress.2018
Author(s)
Lobbezoo F, Ahlberg J, Raphael KG, Wetselaar P, Glaros AG, Kato T, Santiago V, Winocur E, De Laat A, De Leeuw R, Koyano K, Lavigne GJ, Svensson P, Manfredini D.
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Journal Title
Journal of Oral Rehabilitation
Volume: 45
Issue: 11
Pages: 837-844
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Rhythmic masticatory muscle activity (RMMA) index does not decrease with age, conversely to self reports of sleep bruxism: data from sleep laboratories of 3 Continents.2019
Author(s)
Dal Fabbro C, Rompre P, Kato T, Maluly M, Haraki S, Toyota R, Shiraishi Y, Andersen ML, Tufik S, Montplaisir J, Lavigne GJ.
Organizer
WorldSleep2019
Related Report
Int'l Joint Research
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[Presentation] Accuracy of newly developed portable PSG device for detection of sleep bruxism-related masseter EMG muscle activity.2017
Author(s)
Nakazato Y, Takaba M, Yoshida Y, Abe Y, Ono Y, Yoshizawa S, Nakamura H, Kawana F, Suganuma T, Kato T, Baba K.
Organizer
14th World Sleep
Related Report
Int'l Joint Research
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