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Age-related changes of sleep bruxism pathophysiology

Research Project

Project/Area Number 17K19753
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Oral Science and related fields
Research InstitutionOsaka University

Principal Investigator

Kato Takafumi  大阪大学, 歯学研究科, 教授 (50367520)

Co-Investigator(Kenkyū-buntansha) 佐藤 文彦  大阪大学, 歯学研究科, 助教 (60632130)
池邉 一典  大阪大学, 歯学研究科, 教授 (70273696)
三上 章良  大阪府立大学, 総合リハビリテーション学研究科, 教授 (60301272)
Project Period (FY) 2017-06-30 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords睡眠時ブラキシズム / 加齢 / 咀嚼筋活 / 顎運動 / 睡眠関連疾患 / 睡眠 / 咀嚼筋 / 顎口腔機能 / ブラキシズム / ポリソムノグラフィー / 口腔機能
Outline of Final Research Achievements

The results of the present research project showed the followings. 1) Young, otherwise healthy, SB subjects presented normal physiologic variables in sleep architecture, psychologic and cardiac variables. 2) In comparison to young SB subjects, middle-aged SB subjects showed a low quality in sleep architecture such as an increase of microarousals although the frequency of rhythmic masticatory muscle activity (RMMA) did not differ between the groups. However, middle aged SB subjects showed less frequent teeth grinding than young SB subjects. 3) In animals, RMMA, mimicking RMMA in humans, was found to occur in NREM sleep in experimental animals.

Academic Significance and Societal Importance of the Research Achievements

歯ぎしりのような特殊な運動が睡眠中に生じるために、脳の活性化に加え、顎の運動を調節する神経回路が活動が重要であること、さらに加齢に伴う歯ぎしりの変化は、睡眠よりも顎の運動を調節するしくみの変化による可能性が示唆された点で、学術的な意義がある。また、実験動物が歯ぎしり様の運動を示すことから、歯ぎしりが生じるしくみを科学的に研究する方法に、基礎研究を取り入れるオプションが増えた点で社会的意義がある。ヒトの研究と組み合わせることで、診断法や治療法の開発に向けた研究に寄与すると考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (33 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 1 results) Presentation (20 results) (of which Int'l Joint Research: 7 results,  Invited: 8 results) Book (2 results)

  • [Int'l Joint Research] モントリオール大学歯学部(カナダ)

    • Related Report
      2018 Research-status Report
  • [Journal Article] 最新の「睡眠時ブラキシズム」研究について-第1回睡眠時ブラキシズムと睡眠関連疾患-2020

    • Author(s)
      加藤隆史、豊田理紗、白石優季
    • Journal Title

      日本歯科評論

      Volume: 80(4) Pages: 2-4

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Ability to control directional lip-closing force during voluntary lip pursing in healthy young adults.2019

    • Author(s)
      Miyamoto T, Yamada K, Hijiya K, Kageyama T, Kato T, Sugo H, Shimono R, Masuda Y.
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: - Issue: 6 Pages: 526-532

    • DOI

      10.1111/joor.12776

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sleep quality, psychological profiles, cardiac activity and salivary biomarkers in young subjects with different degrees of rhythmic masticatory muscle activity: a polysomnography study.2019

    • Author(s)
      Haraki S, Tsujisaka A, Nonoue S, Nochino T, Kamimura M, Adachi H, Ishigaki S, Yatani H, Taniike M, Kato T.
    • Journal Title

      Journal of Oral & Facial Pain and Headache

      Volume: 33 Issue: 1 Pages: 105-113

    • DOI

      10.11607/ofph.2231

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sleep Stage Estimation Method Using a Camera for Home Use2019

    • Author(s)
      Teruaki NOCHINO,Yuko OHNO,Takafumi KATO,Masako TANIIKE,Shima OKADA
    • Journal Title

      Springer, Biomedical Engineering Letters

      Volume: 9 Issue: 2 Pages: 257-265

    • DOI

      10.1007/s13534-019-00108-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 歯ぎしり評価の臨床的意義と、その評価方法について教えてください2019

    • Author(s)
      加藤隆史, 白石優季,豊田理紗,原木真吾,辻阪亮子
    • Journal Title

      睡眠医療

      Volume: 13(2) Pages: 237-241

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 歯ぎしり評価の臨床的意義と、その評価方法について教えてください。2019

    • Author(s)
      加藤隆史、白石優季、豊田理紗、原木真吾、辻阪亮子
    • Journal Title

      睡眠医療

      Volume: -

    • Related Report
      2018 Research-status Report
  • [Journal Article] International consensus on the assessment of bruxism: Report of a work in progress.2018

    • Author(s)
      Lobbezoo F, Ahlberg J, Raphael KG, Wetselaar P, Glaros AG, Kato T, Santiago V, Winocur E, De Laat A, De Leeuw R, Koyano K, Lavigne GJ, Svensson P, Manfredini D.
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: 45 Issue: 11 Pages: 837-844

    • DOI

      10.1111/joor.12663

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The occurrence of respiratory events in young subjects with a frequent rhythmic masticatory muscle activity: a pilot study2018

    • Author(s)
      Tsujisaka Akiko、Haraki Shingo、Nonoue Shigeru、Mikami Akira、Adachi Hiroyoshi、Mizumori Takahiro、Yatani Hirofumi、Yoshida Atsushi、Kato Takafumi
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 62 Issue: 3 Pages: 317-323

    • DOI

      10.1016/j.jpor.2017.12.004

    • NAID

      130007458276

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 睡眠時ブラキシズム2018

    • Author(s)
      加藤隆史
    • Journal Title

      ねむりとマネージメント

      Volume: 5 №1 Pages: 50-53

    • Related Report
      2017 Research-status Report
  • [Journal Article] Statistical sleep pattern modelling for sleep quality assessment based on sound events2017

    • Author(s)
      Wu Hongle、Kato Takafumi、Numao Masayuki、Fukui Ken-ichi
    • Journal Title

      Health Information Science and systems

      Volume: 5 Issue: 1 Pages: 11-11

    • DOI

      10.1007/s13755-017-0031-z

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Rhythmic Masticatory Muscle Activity in Sleep Bruxism Children2019

    • Author(s)
      Y.Shiraishi, M. Tachibana,A. Shirota,I. Mohri, M.Taniike,T.Yamashiro,T.Kato
    • Organizer
      97th.IADR General Session
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Association between rhythmic masticatory muscle activity and sleep arousals in sleep bruxism children2019

    • Author(s)
      Yuki Shiraishi, Masaya Tachibana, Ai Shirota, Ikuko Mohri, Masako Taniike, Takashi Yamashiro, Takafumi Kato
    • Organizer
      Oral Neuroscience 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The role of the dentist in the assessment and management of sleep bruxism2019

    • Author(s)
      Takafumi Kato
    • Organizer
      97th.IADR General Session
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 睡眠時ブラキシズムの研究の壁2019

    • Author(s)
      加藤隆史
    • Organizer
      日本顎口腔機能学会第63回学術大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ブラキシズムと上手につきあうために2019

    • Author(s)
      加藤隆史
    • Organizer
      公益社団法人日本補綴歯科学会第128回学術大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Rhythmic masticatory muscle activity (RMMA) index does not decrease with age, conversely to self reports of sleep bruxism: data from sleep laboratories of 3 Continents.2019

    • Author(s)
      Dal Fabbro C, Rompre P, Kato T, Maluly M, Haraki S, Toyota R, Shiraishi Y, Andersen ML, Tufik S, Montplaisir J, Lavigne GJ.
    • Organizer
      WorldSleep2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 若年成人の終夜ポリグラフ記録における第一夜効果2018

    • Author(s)
      城田愛、後野光覚、上村真代、原木真吾、辻阪亮子、谷池雅子、加藤隆史
    • Organizer
      第10回日本臨床睡眠医学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 睡眠時ブラキシズム:睡眠医学と歯科医学のはざまで2018

    • Author(s)
      加藤隆史
    • Organizer
      第10回日本臨床睡眠医学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 睡眠時ブラキシズム:basic science and clinical perspectives2018

    • Author(s)
      加藤隆史
    • Organizer
      第17回日本睡眠歯科学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 閉塞性睡眠時無呼吸症候群の基礎2018

    • Author(s)
      加藤隆史
    • Organizer
      第28回 日本顎変形症学会総会・学術大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 小児における睡眠時リズム性咀嚼筋活動の発生様式2018

    • Author(s)
      白石優季、橘雅弥、Sheng-Yun Lu、城田愛、毛利育子、辻阪亮子、谷池雅子、山城隆、加藤隆史
    • Organizer
      第10回日本臨床睡眠医学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 若年成人睡眠時ブラキシズムにおけるレム睡眠の咬筋活動特性2018

    • Author(s)
      豊田理紗、大倉睦美、野々上茂、原木真吾、辻阪亮子、足立浩祥、加藤隆史
    • Organizer
      第10回日本臨床睡眠医学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 携帯型睡眠検査装置による睡眠時ブラキシズム記録の妥当性検証2018

    • Author(s)
      中里友香理,高場雅之,吉田裕哉,安部友佳,葭澤秀一郎,中村浩崇,川名ふさ江,菅沼岳史,加藤隆史,矢谷博文,馬場一美
    • Organizer
      第60回日本顎口腔機能学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 明期の間歇的低酸素がラットの口腔顔面領域の体性感覚に与える影響2018

    • Author(s)
      岸本沙樹,片桐綾乃,豊田博紀,丹羽 均,加藤隆史
    • Organizer
      第12回 三叉神経領域の感覚-運動統合機構研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 睡眠時ブラキシズムの基礎2018

    • Author(s)
      加藤隆史
    • Organizer
      日本補綴歯科学会関西支部総会ならびに学術大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 睡眠中の顎口腔機能異常の病態生理の解析基盤2017

    • Author(s)
      加藤隆史
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Distinct first night effects for rhythmic and non-rhythmic masticatory muscle activities in young adults.2017

    • Author(s)
      Haraki S, Nonoue M, Tsujisaka A, Mikami A, Ishigaki S, Mizumori T, Yatani H, Yoshida A, Kato T.
    • Organizer
      14th World Sleep
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Accuracy of newly developed portable PSG device for detection of sleep bruxism-related masseter EMG muscle activity.2017

    • Author(s)
      Nakazato Y, Takaba M, Yoshida Y, Abe Y, Ono Y, Yoshizawa S, Nakamura H, Kawana F, Suganuma T, Kato T, Baba K.
    • Organizer
      14th World Sleep
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] SPONTANEOUS AROUSAL RELATED EXPIRATORY MOUTH LEAK DURING CPAP TITRATION PREDICT NON-ADHERENCE IN OSAS PATIENTS2017

    • Author(s)
      M. Mashita, S. Nonoue, T. Kato, Y. Shigedo, K. Kyotani, H. Adachi, A.Mikami
    • Organizer
      14th World Sleep
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 睡眠時ブラキシズムにおけるリズム性および非リズム性咀嚼筋活動の相反性初夜効果2017

    • Author(s)
      原木真吾,辻阪亮子,石垣尚一,瑞森崇弘,矢谷博文,加藤隆史
    • Organizer
      第126回日本補綴歯科学会学術大会
    • Related Report
      2017 Research-status Report
  • [Book] Sleep Medicine For Dentists 2nd eds, Role of Dentists in Sleep Medicine2020

    • Author(s)
      Lavigne GJ, Heinzer RC, Dal Fabbro C, Smith MT, Masse J-F, Almeida FR, Kato T, Lobbezoo F, Cistulli PA.
    • Total Pages
      224
    • Publisher
      Quintessence publishing
    • Related Report
      2019 Annual Research Report
  • [Book] 新よくわかる顎口腔機能-咬合・摂食嚥下・発音を理解する-,睡眠時ブラキシズムの評価法.2017

    • Author(s)
      98. 加藤隆史.
    • Total Pages
      287
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2017 Research-status Report

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Published: 2017-07-21   Modified: 2021-02-19  

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