Elucidation of novel mitochondrial functions in the regulation of inflammation
| Project/Area Number |
17K19768
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Oral Science and related fields
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| Research Institution | Nagasaki University |
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Principal Investigator |
TAKEDA Kohsuke 長崎大学, 医歯薬学総合研究科(薬学系), 教授 (10313230)
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| Project Period (FY) |
2017-06-30 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 炎症 / ミトコンドリア / インフラマソーム / シグナル伝達 |
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| Outline of Final Research Achievements |
Extracellular ATP functions as a danger signal that transduces information on tissue damage to the immune system. In this research, we examined the role of mitochondria in the production and secretion of interleukin 1β (IL-1β), an inflammatory cytokine, in inflammatory cells such as macrophages in response to extracellular ATP. We found that the intake of calcium by functional mitochondria downstream of the ligand-operated ion channel P2X7 that functions as a receptor for ATP appears to play an important role in ATP-induced IL-1β secretion.
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| Academic Significance and Societal Importance of the Research Achievements |
近年、さまざまな疾患の病因あるいは増悪因子として慢性炎症が注目されていることから、炎症の程度や持続時間を制御する機構の解明が急務である。その足がかりとなるのが、炎症のトリガーとして働く炎症性サイトカインIL-1βの産生機構の解明である。本研究では、IL-1βの産生にミトコンドリアの機能が重要であることが明らかとなったことから、ミトコンドリアの機能を維持することが慢性炎症をコントロールする一つの方策となることが示唆される。
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] WP1066 suppresses macrophage cell death induced by inflammasome agonists independently of its inhibitory effect on STAT3.2017
Author(s)
Honda, S., Sadatomi, D., Yamamura, Y., Nakashioya, K., Tanimura, S. and Takeda, K.
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Journal Title
Cancer Sci.
Volume: 108
Issue: 3
Pages: 520-527
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Structures of PGAM5 provide insight into active site plasticity and multimeric assembly.2017
Author(s)
Chaikuad, A., Filippakopoulos, P., Marcsisin, S. R., Picaud, S., Schroder, M., Sekine, S., Ichij, H., Engen, J. R., Takeda, K., Knapp, S.
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Journal Title
Structure 25, 1089-1099 (2017)
Volume: 25
Issue: 7
Pages: 1089-1099
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y12 in platelets.2017
Author(s)
Kamiyama, M., Shirai, T., Tamura, S., Suzuki-Inoue, K., Ehata, S., Takahashi, K., Miyazono, K., Hayakawa, Y., Sato, T., Takeda, K., Naguro, I., Ichijo, H.
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Journal Title
Cell Death and Differentiation
Volume: 24
Issue: 12
Pages: 2066-2076
DOI
Related Report
Peer Reviewed
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