Research Project
Grant-in-Aid for Challenging Research (Exploratory)
Extracellular ATP functions as a danger signal that transduces information on tissue damage to the immune system. In this research, we examined the role of mitochondria in the production and secretion of interleukin 1β (IL-1β), an inflammatory cytokine, in inflammatory cells such as macrophages in response to extracellular ATP. We found that the intake of calcium by functional mitochondria downstream of the ligand-operated ion channel P2X7 that functions as a receptor for ATP appears to play an important role in ATP-induced IL-1β secretion.
近年、さまざまな疾患の病因あるいは増悪因子として慢性炎症が注目されていることから、炎症の程度や持続時間を制御する機構の解明が急務である。その足がかりとなるのが、炎症のトリガーとして働く炎症性サイトカインIL-1βの産生機構の解明である。本研究では、IL-1βの産生にミトコンドリアの機能が重要であることが明らかとなったことから、ミトコンドリアの機能を維持することが慢性炎症をコントロールする一つの方策となることが示唆される。
All 2019 2018 2017
All Journal Article (6 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 6 results, Open Access: 4 results, Acknowledgement Compliant: 1 results) Presentation (21 results) (of which Int'l Joint Research: 2 results, Invited: 2 results)
The Journal of Biochemistry
Volume: 165 Issue: 1 Pages: 19-25
10.1093/jb/mvy077
Biochimica et Biophysica Acta (BBA) - General Subjects
Volume: 1862 Issue: 10 Pages: 2271-2280
10.1016/j.bbagen.2018.07.015
Cancer Sci.
Volume: 108 Issue: 3 Pages: 520-527
10.1111/cas.13154
Structure 25, 1089-1099 (2017)
Volume: 25 Issue: 7 Pages: 1089-1099
10.1016/j.str.2017.05.020
Cell Death and Differentiation
Volume: 24 Issue: 12 Pages: 2066-2076
10.1038/cdd.2017.114
J Biochem
Volume: 162 Issue: 3 Pages: 145-154
10.1093/jb/mvx048
