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Health age indices and gut microbiota from the Iwaki big data

Research Project

Project/Area Number 17K19781
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Society medicine, Nursing, and related fields
Research InstitutionHirosaki University

Principal Investigator

Nakaji Shigeyuki  弘前大学, 医学研究科, 特任教授 (10192220)

Co-Investigator(Kenkyū-buntansha) 沢田 かほり  弘前大学, 医学研究科, 助教 (50624889)
倉内 静香  弘前大学, 医学研究科, 講師 (60455730)
相馬 優樹  弘前大学, 医学研究科, 助教 (60792372)
徳田 糸代  弘前大学, 医学研究科, 助教 (90792391)
小笠原 悠  弘前大学, 医学研究科, 助手 (40809844)
Project Period (FY) 2017-06-30 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords健康年齢 / 岩木健康増進プロジェクト / ビッグデータ / ビッグデータ解析 / 16S-rDNA / 腸内細菌 / 健康指標
Outline of Final Research Achievements

In this research, the calculation formulas of various health ages (gut, lung, blood vessels, bones, physical strength, brain, oral cavity) are calculated by comprehensive analyzing the big data of the Iwaki Health Promotion Project in 2017 and 2018. The results are as follows. (1) Formulas for various health ages were calculated from the big data of the Iwaki Health Promotion Project of 2017. The main items used in the formula were alcohol intake, energy intake, dietary fiber intake, diabetes incidence, triglyceride fat area, abdominal circumference,γGTP, IgE, cognitive function, depression degree, amino acid, leptin and so on. (2) We also calculated the calculation formula using the big data of the Iwaki Health Promotion Project of 2018. Furthermore, these two formulas were compared each other.

Academic Significance and Societal Importance of the Research Achievements

提唱されている既存の各種健康年齢は、異なる対象者から、各研究者が独自の単独の健康年齢を提案している。また、時間的ずれもある。そこで、本研究では、岩木健康増進プロジェクトのビッグデータを総合的に同時に解析することで、各種健康年齢(腸・肺・血管・骨・体力・脳・口腔)の計算式を一括して開発した。本研究の特色と長所は、同一のデータから7つの健康年齢の計算式を同時に開発したことであり、しかもこの7つの健康年齢は健康長寿をほぼカバーできるものである。今後の健康対策は、健康を全体的にとらえるという視点が重要であり、本研究で作成した7つの式はその目的に合致し、今後の健康対策に貢献できるものとして期待される。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (25 results)

All 2019 2018 2017 Other

All Journal Article (17 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 17 results,  Open Access: 16 results) Presentation (7 results) (of which Invited: 5 results) Remarks (1 results)

  • [Journal Article] Daidzein Intake Is Associated with Equol Producing Status through an Increase in the Intestinal Bacteria Responsible for Equol Production2019

    • Author(s)
      Iino Chikara、Shimoyama Tadashi、Iino Kaori、Yokoyama Yoshihito、Chinda Daisuke、Sakuraba Hirotake、Fukuda Shinsaku、Nakaji Shigeyuki
    • Journal Title

      Nutrients

      Volume: 11 Issue: 2 Pages: 433-433

    • DOI

      10.3390/nu11020433

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations between cervical disc degeneration and muscle strength in a cross-sectional population-based study.2019

    • Author(s)
      Kumagai G, Wada K, Kudo H, Asari T, Chiba D, Ota S, Takeda O, Koyama K, Nakaji S, Ishibashi Y.
    • Journal Title

      PLoS One

      Volume: 14 Issue: 1 Pages: e0210802-e0210802

    • DOI

      10.1371/journal.pone.0210802

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship Between Serum Eicosapentaenoic Acid Levels and J-Waves in a General Population in Japan2018

    • Author(s)
      Kimura Y, Yamada M, Hanada K, Endo T, Narita N, Narita M, Senoo M, Yonekura M, Ichikawa H, Kurauchi S, Nakaji S, Okumura K, Tomita H.
    • Journal Title

      International Heart Journal

      Volume: 59 Issue: 4 Pages: 736-740

    • DOI

      10.1536/ihj.17-434

    • NAID

      130007427690

    • ISSN
      1349-2365, 1349-3299
    • Year and Date
      2018-07-31
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A study of the factors associated with cervical spinal disc degeneration, with a focus on bone metabolism and amino acids, in the Japanese population: a cross sectional study.2018

    • Author(s)
      Wada K, Tanaka T, Kumagai G, Kudo H, Asari T, Chiba D, Ota S, Kamei K, Takeda O, Nakaji S, Ishibashi Y.
    • Journal Title

      BMC Musculoskelet Disord

      Volume: 19 Issue: 1 Pages: 153-153

    • DOI

      10.1186/s12891-018-2055-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sleep Disturbance Has a Higher Impact on General and Mental Quality of Life Reduction than Nocturia: Results from the Community Health Survey in Japan2018

    • Author(s)
      Kido Koichi、Hatakeyama Shingo、Imai Atsushi、Yamamoto Hayato、Tobisawa Yuki、Yoneyama Tohru、Yoneyama Takahiro、Hashimoto Yasuhiro、Koie Takuya、Nakaji Shigeyuki、Ohyama Chikara
    • Journal Title

      European Urology Focus

      Volume: 99 Issue: 6 Pages: 0001-0001

    • DOI

      10.1016/j.euf.2018.04.017

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical implication of a quantitative frailty assessment tool for prognosis in patients with urological cancers2018

    • Author(s)
      Soma Osamu、Hatakeyama Shingo、Okamoto Teppei、Fujita Naoki、Matsumoto Teppei、Tobisawa Yuki、Yoneyama Tohru、Yamamoto Hayato、Yoneyama Takahiro、Hashimoto Yasuhiro、Koie Takuya、Nakaji Shigeyuki、Ohyama Chikara
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 25 Pages: 0001-0001

    • DOI

      10.18632/oncotarget.24712

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Infection of Helicobacter pylori and Atrophic Gastritis Influence Lactobacillus in Gut Microbiota in a Japanese Population2018

    • Author(s)
      Iino Chikara、Shimoyama Tadashi、Chinda Daisuke、Arai Tetsu、Chiba Daisuke、Nakaji Shigeyuki、Fukuda Shinsaku
    • Journal Title

      Frontiers in Immunology

      Volume: 9 Pages: 712-712

    • DOI

      10.3389/fimmu.2018.00712

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Age-related reduction of trunk muscle torque and prevalence of trunk sarcopenia in community-dwelling elderly: Validity of a portable trunk muscle torque measurement instrument and its application to a large sample cohort study2018

    • Author(s)
      Sasaki Eiji、Sasaki Shizuka、Chiba Daisuke、Yamamoto Yuji、Nawata Atsushi、Tsuda Eiichi、Nakaji Shigeyuki、Ishibashi Yasuyuki
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 2 Pages: e0192687-e0192687

    • DOI

      10.1371/journal.pone.0192687

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations between neck symptoms and LDL cholesterol in a cross-sectional population-based study2018

    • Author(s)
      Kumagai Gentaro、Wada Kanichiro、Tanaka Toshihiro、Kudo Hitoshi、Asari Toru、Chiba Daisuke、Ota Seiya、Nakaji Shigeyuki、Ishibashi Yasuyuki
    • Journal Title

      J Orthop Sci.

      Volume: 23 Issue: 2 Pages: 277-281

    • DOI

      10.1016/j.jos.2017.11.002

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Irritable bowel syndrome and quality of life in a community-dwelling population in Japan2017

    • Author(s)
      Sugawara Norio、Sato Ken、Takahashi Ippei、Satake Ryu、Fukuda Shinsaku、Nakaji Shigeyuki、Yasui-Furukori Norio
    • Journal Title

      The International Journal of Psychiatry in Medicine

      Volume: 53 Issue: 3 Pages: 159-170

    • DOI

      10.1177/0091217417749791

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between cognitive function and balance in a community-dwelling population in Japan2017

    • Author(s)
      Goto Shinichi、Sasaki Akira、Takahashi Ippei、Mitsuhashi Yuri、Nakaji Shigeyuki、Matsubara Atsushi
    • Journal Title

      Acta Oto-Laryngologica

      Volume: 138 Issue: 5 Pages: 471-474

    • DOI

      10.1080/00016489.2017.1408142

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Application of a stratum-specific likelihood ratio analysis in a screen for depression among a community-dwelling population in Japan2017

    • Author(s)
      Sugawara Norio、Kaneda Ayako、Takahashi Ippei、Nakaji Shigeyuki、Yasui-Furukori Norio
    • Journal Title

      Neuropsychiatr Dis Treat.

      Volume: Volume 13 Pages: 2369-2374

    • DOI

      10.2147/ndt.s142517

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Meniscal extrusion seen on ultrasonography affects the development of radiographic knee osteoarthritis: a 3-year prospective cohort study2017

    • Author(s)
      Chiba Daisuke、Maeda Shugo、Sasaki Eiji、Ota Seiya、Nakaji Shigeyuki、Tsuda Eiichi、Ishibashi Yasuyuki
    • Journal Title

      Clinical Rheumatology

      Volume: 36 Issue: 11 Pages: 2557-2564

    • DOI

      10.1007/s10067-017-3803-6

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decrease of Estradiol and Several Lifestyle Factors, but Not <b><i>Helicobacter pylori</i></b> Infection, Are Significant Risks for Osteopenia in Japanese Females2017

    • Author(s)
      Chinda Daisuke、Shimoyama Tadashi、Iino Chikara、Matsuzaka Masashi、Nakaji Shigeyuki、Fukuda Shinsaku
    • Journal Title

      Digestion

      Volume: 96 Issue: 2 Pages: 103-109

    • DOI

      10.1159/000479317

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dominance of the hypothalamus-pituitary-adrenal axis over the renin-angiotensin-aldosterone system is a risk factor for decreased insulin secretion.2017

    • Author(s)
      Daimon M, Kamba A, Murakami H, Mizushiri S, Osonoi S, Matsuki K, Sato E, Tanabe J, Takayasu S, Matsuhashi Y, Yanagimachi M, Terui K, Kageyama K, Tokuda I, Kurauchi S, Nakaji S.
    • Journal Title

      Sci Rep.

      Volume: 12 Issue: 1 Pages: 11360-11360

    • DOI

      10.1038/s41598-017-10815-y

    • NAID

      120006576915

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The influence of serum uric acid on renal function in patients with calcium or uric acid stone: A population-based analysis2017

    • Author(s)
      Tanaka Yoshimi、Hatakeyama Shingo、Tanaka Toshikazu、Yamamoto Hayato、Narita Takuma、Hamano Itsuto、Matsumoto Teppei、Soma Osamu、Okamoto Teppei、Tobisawa Yuki、Yoneyama Tohru、Yoneyama Takahiro、Hashimoto Yasuhiro、Koie Takuya、Takahashi Ippei、Nakaji Shigeyuki、Terayama Yuriko、Funyu Tomihisa、Ohyama Chikara
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 7 Pages: e0182136-e0182136

    • DOI

      10.1371/journal.pone.0182136

    • NAID

      120006583354

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 弘前市の一般住民における腸内細菌の種多様性と加齢との関係2017

    • Author(s)
      棟方理、高橋一平、相馬優樹、倉内静香、大圃研、上谷英史、高橋和幸、甲斐知彦、久田貴義、辨野義己、村下公一、中路重之.
    • Journal Title

      体力・栄養・免疫学雑誌

      Volume: 27 Pages: 128-136

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 真の社会イノベーションを実現する革新的「健やか力」創造拠点2019

    • Author(s)
      中路重之
    • Organizer
      出生コホート研究連携ワークショップ
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 中路重之.短命県返上、地域・職域・学校でのもう一歩の取り組み2018

    • Author(s)
      中路重之
    • Organizer
      .第3回青森県医学会県民公開講座
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 岩木プロジェクト健診の紹介2018

    • Author(s)
      中路重之
    • Organizer
      国際コンソーシアム協定連携シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 青森県の短命返上活動から見えてくるもの:世界一の健康ビッグデータに答えはあるか?2018

    • Author(s)
      中路重之
    • Organizer
      第13回日本応用老年学会大会 学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 青森県の短命県返上と地方創生2018

    • Author(s)
      中路重之
    • Organizer
      日本産学フォーラム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] "一般住民健診におけるメタボリック症候群と血清テストステロン濃度の関係について2018

    • Author(s)
      松本哲平, 畠山真吾, 山本勇人, 今井篤, 米山高弘, 橋本安弘, 古家琢也, 中路重之, 大山力
    • Organizer
      第106回日本泌尿器科学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 弘前市の一般住民における腸内細菌の多様性に関する検討2017

    • Author(s)
      棟方理 ,相馬優樹,小笠原悠,大圃研,上谷英史,甲斐知彦, 野村忠宏,中路重之
    • Organizer
      第27回体力栄養免疫学会大会
    • Related Report
      2017 Research-status Report
  • [Remarks] 真の社会イノベーションを実現する革新的「健やか力」創造拠点 研究・実績

    • URL

      http://coi.hirosaki-u.ac.jp/web/performance.html

    • Related Report
      2018 Annual Research Report

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Published: 2017-07-21   Modified: 2020-03-30  

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