| Project/Area Number |
17K19818
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Society medicine, Nursing, and related fields
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| Research Institution | Hiroshima University |
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Principal Investigator |
Sobue Ikuko 広島大学, 医系科学研究科(保), 教授 (80171396)
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| Co-Investigator(Kenkyū-buntansha) |
小澤 未緒 広島大学, 医系科学研究科(保), 准教授 (80611318)
竹中 和子 広島大学, 医系科学研究科(保), 講師 (90227041)
植松 裕子 人間環境大学, 看護学部, 講師 (00808909)
桐本 光 広島大学, 医系科学研究科(保), 教授 (40406260)
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| Project Period (FY) |
2017-06-30 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2019: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2018: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2017: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 早期産児 / 疼痛 / 脳 / 誘発電位 / 小児看護学 / 疼痛緩和 / 正期産児 / 音楽 / 看護学 |
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| Outline of Final Research Achievements |
The purpose of this study was to elucidate the degree of invasiveness of treatment pain in preterm and term infants focusing on the sensory regions of the brain (somatosensory area, auditory area), and to develop a pain relief method.
We have developed new interventions (music, pacifiers, facilitated tucking and holding) that are more analgesic than the various previous interventions for heel puncture in preterm infants.A systematic review suggested the need for Aδ and C fiber stimulation-induced event-related potential (ERP) studies associated with neonatal heel puncture to establish ERP pain assessment for neonatal heel puncture. Studies in healthy adults showed a reduction in ERP latency, even though the blade of the lance device was inserted into depth of 0.1 mm in the epidermis where the free nerve endings of Aδ fibers are located, suggesting that ERP may not reflect treatment pain.
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| Academic Significance and Societal Importance of the Research Achievements |
新生児は、頻回の疼痛によって、脳と神経の発達や認知・運動・行動に短期的・長期的悪影響を被る。本研究において開発した踵穿刺に対する非薬理的疼痛緩和法は、疼痛緩和効果が高く簡便であり、NICUでの活用が期待できる。新生児の踵穿刺によって誘発される事象関連電位の体系的レビュー及び今回実施した疼痛によって誘発される事象関連電位の評価は、新生児の踵穿刺における疼痛評価と介入法開発への寄与が期待できる。
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