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Elucidation of treatment pain and development of alleviation methods for preterm and term infants due to brain localization and network development

Research Project

Project/Area Number 17K19818
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Society medicine, Nursing, and related fields
Research InstitutionHiroshima University

Principal Investigator

Sobue Ikuko  広島大学, 医系科学研究科(保), 教授 (80171396)

Co-Investigator(Kenkyū-buntansha) 小澤 未緒  広島大学, 医系科学研究科(保), 准教授 (80611318)
竹中 和子  広島大学, 医系科学研究科(保), 講師 (90227041)
植松 裕子  人間環境大学, 看護学部, 講師 (00808909)
桐本 光  広島大学, 医系科学研究科(保), 教授 (40406260)
Project Period (FY) 2017-06-30 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2019: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2018: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2017: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywords早期産児 / 疼痛 / 脳 / 誘発電位 / 小児看護学 / 疼痛緩和 / 正期産児 / 音楽 / 看護学
Outline of Final Research Achievements

The purpose of this study was to elucidate the degree of invasiveness of treatment pain in preterm and term infants focusing on the sensory regions of the brain (somatosensory area, auditory area), and to develop a pain relief method.
We have developed new interventions (music, pacifiers, facilitated tucking and holding) that are more analgesic than the various previous interventions for heel puncture in preterm infants.A systematic review suggested the need for Aδ and C fiber stimulation-induced event-related potential (ERP) studies associated with neonatal heel puncture to establish ERP pain assessment for neonatal heel puncture. Studies in healthy adults showed a reduction in ERP latency, even though the blade of the lance device was inserted into depth of 0.1 mm in the epidermis where the free nerve endings of Aδ fibers are located, suggesting that ERP may not reflect treatment pain.

Academic Significance and Societal Importance of the Research Achievements

新生児は、頻回の疼痛によって、脳と神経の発達や認知・運動・行動に短期的・長期的悪影響を被る。本研究において開発した踵穿刺に対する非薬理的疼痛緩和法は、疼痛緩和効果が高く簡便であり、NICUでの活用が期待できる。新生児の踵穿刺によって誘発される事象関連電位の体系的レビュー及び今回実施した疼痛によって誘発される事象関連電位の評価は、新生児の踵穿刺における疼痛評価と介入法開発への寄与が期待できる。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (7 results)

All 2021 2020 2019 2018 2017

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (4 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Can Event-Related Potentials Evoked by Heel Lance Assess Pain Processing in Neonates? A Systematic Review2021

    • Author(s)
      Shiroshita Yui、Kirimoto Hikari、Ozawa Mio、Watanabe Tatsunori、Uematsu Hiroko、Yunoki Keisuke、Sobue Ikuko
    • Journal Title

      Children

      Volume: 8 Issue: 2 Pages: 58-58

    • DOI

      10.3390/children8020058

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evoked potential as a pain evaluation index for neonatal procedural pain2020

    • Author(s)
      Shiroshita Yui, Kirimoto Hikari, Nakagawa Satoshi, Uematsu Hiroko, Sobue Ikuko
    • Journal Title

      International Journal of Nursing & Clinical Practices

      Volume: -

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of music (Brahms lullaby) and non-nutritive sucking on heel lance in preterm infants: A randomized controlled crossover trial (in press)2018

    • Author(s)
      Hiroko Uematsu, Ikuko Sobue
    • Journal Title

      Paediatrics & Child Health

      Volume: 23

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] A literature review on the effects of pharmacological intervention for heel lance pain in neonates2020

    • Author(s)
      Shiroshita Yui, Sobue Ikuko, Torobu Akemi
    • Organizer
      The 7th Asian Symposium on Healthcare Without Borders
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pain associated with heel lance in newborns by measuring evoked potentials in electroencephalography: A basic research study involving adults2020

    • Author(s)
      Shiroshita Yui, Kirimoto Hikari, Nakagawa Satoshi, Tomoyasu Yukiko, Kamei Tatsuya, Sobue Ikuko
    • Organizer
      The 6th International Nursing Research Conference of World Academy of Nursing Science
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 新生児のかかと穿刺痛に対する疼痛緩和法を開発するための文献検討2019

    • Author(s)
      城下由衣,祖父江育子
    • Organizer
      日本看護研究学会第24回九州・沖縄地方会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Literature review on the effects of music to reduce pain experienced by pediatric patients undergoing medical treatment2017

    • Author(s)
      Yui Yamane,Ikuko Sobue
    • Organizer
      The 5th Asian Symposium on Healthcare without Borders
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-07-21   Modified: 2022-01-27  

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