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Genetic and epidemiological analysis of noise-induced hearing loss (NIHL) towards its tailor-made medicine and prevention

Research Project

Project/Area Number 17K19863
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Society medicine, Nursing, and related fields
Research InstitutionNational Defense Medical College

Principal Investigator

Shinomiya Nariyoshi  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 分子生体制御学, 教授 (40505260)

Co-Investigator(Kenkyū-buntansha) 松尾 洋孝  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 分子生体制御学, 准教授 (00528292)
山本 健  久留米大学, 医学部, 教授 (60274528)
Research Collaborator Shiotani Akihiro  
Mizutari Kunio  
Project Period (FY) 2017-06-30 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords分子遺伝疫学 / 個別化予防 / QOL / 聴力 / 予防医学・疫学
Outline of Final Research Achievements

Noise-induced hearing loss (NIHL) is one of the most common sensorineural hearing deficits. It is known that susceptibility to NIHL greatly depends on individual variation, but it is remained to be clarified. In the present study, subjects are from participants of health checkups for 50-years-old Japanese Defense Force personnel. We performed comprehensive genetic analysis on their data including hearing tests and laboratory data of health checkups. We also conducted the establishment of research resource and preparation of cooperation on the analyses. Moreover, we performed target gene analysis for candidate genes of hearing loss including NRF2, and a genome-wide association analysis (GWAS) of NIHL. These analyses will provide the results which lead personalized genomic prevention and medication for NIHL.

Academic Significance and Societal Importance of the Research Achievements

本研究では、難聴の感受性遺伝子の同定において複数の観点から理想的な対象サンプルの解析を大規模かつ網羅的に実施した。世界の人口の1割が悩まされている「難聴」、特に「感音難聴」には騒音性難聴の他、加齢性難聴(老人性難聴)も含まれるが、両者には酸化的ストレスなどの共通したメカニズムがあることが知られている。これまでの我々の成果からも、騒音性難聴になりやすい遺伝子多型が見いだされ、その予防への応用に資する成果が得られている。そのため、難聴の予防に資する遺伝子の発見を目的とした本研究は、日本のみならず世界の人々の健康増進や高齢化社会における活躍機会の増進にも大いに役立つことが期待できる。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (5 results)

All 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] A common variant of MAF/c-MAF, transcriptional factor gene in the kidney, is associated with gout susceptibility.2018

    • Author(s)
      Higashino T, Matsuo H, Okada Y, Nakashima H, Shimizu S, Sakiyama M, Tadokoro S, Nakayama A, Kawaguchi M, Komatsu M, Hishida A, Nakatochi M, Ooyama H, Imaki J, Shinomiya N.
    • Journal Title

      Human Cell

      Volume: 31 Issue: 1 Pages: 10-13

    • DOI

      10.1007/s13577-017-0186-6

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Independent effects of ADH1B and ALDH2 common dysfunctional variants on gout risk.2017

    • Author(s)
      Sakiyama M, Matsuo H, Akashi A, Shimizu S, Higashino T, Kawaguchi M, Nakayama A, Naito M, Kawai S, Nakashima H, Sakurai Y, Ichida K, Shimizu T, Ooyama H, Shinomiya N.
    • Journal Title

      Scientific Report

      Volume: 7 Issue: 1 Pages: 2500-2500

    • DOI

      10.1038/s41598-017-02528-z

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ADH1B とALDH2 の機能低下型多型は痛風発症と関連する.2018

    • Author(s)
      小松 眞子、松尾 洋孝、崎山 真幸、川口 真、中山 昌喜、長尾 優太郎、内藤 真理子、川合 紗世、中島 宏、櫻井 裕、清水 徹、大山 博司、四ノ宮 成祥
    • Organizer
      第28回日本疫学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Genome-wide association study of clinicallydefined gout and subtypes identifies multiple susceptibility loci including transporter genes.2017

    • Author(s)
      Hirotaka Matsuo, Nakayama Akiyoshi, Hirofumi Nakaoka, et al.
    • Organizer
      67th Annual Meeting of the American Society of Human Genetics.
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 臨床診断された痛風とサブタイプ症例のゲノムワイド関連解析によるトランスポーター遺伝子を含む10 ヵ所の痛風関連遺伝子座の同定2017

    • Author(s)
      中山昌喜、松尾洋孝、他
    • Organizer
      日本人類遺伝学会第62回大会
    • Related Report
      2017 Research-status Report

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Published: 2017-07-21   Modified: 2020-03-30  

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