| Project/Area Number |
17K19873
|
|---|
| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Society medicine, Nursing, and related fields
|
|---|
| Research Institution | National Cardiovascular Center Research Institute |
|---|
Principal Investigator |
Kokubo Yoshihiro 国立研究開発法人国立循環器病研究センター, 病院, 医長 (20393217)
|
|---|
| Project Period (FY) |
2017-06-30 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2019)
|
| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 頸動脈硬化 / プラーク進展 / 循環器病 / 追跡研究 / 危険因子 / リスクスコア / 頸動脈プラーク / 地域住民 / 頸動脈硬化症 / 内膜中膜複合体厚 / 脳卒中 / 虚血性心疾患 / 予防医学 |
|---|
| Outline of Final Research Achievements |
No prospective study of the relationship between IMT progression and incident CVD has been performed. We studied 4724 participants without CVD who had carotid ultrasonography. Carotid ultrasonographic follow-up was performed every 2 years, newly revealing 193 CCA plaques. During the 59,909 person-years of follow-up, we observed 221 strokes and 154 CHD events. CCA plaque was a risk factor for CVD. Also, we developed a scoring system for each risk factor as follows: 2, 4, 6, 9, and 11 points for age 40's to 80's; -1 point for women; 1, and 2 points for SBP=120-159, and ≧160mmHg; 1, 2, and 3 points for TC=160-239, 240-279, and ≧280mg/dL; 2, and -1 points for HDLC<35 and ≧60mg/dL; 1 point for overweight or current smoking; and 2 points for diabetes. In conclusion, this study provides the first demonstration that new progression of incident CCA plaque is a CVD risk. We have developed a 10-year risk score for the plaque in routine health examinations and outpatients.
|
| Academic Significance and Societal Importance of the Research Achievements |
生活習慣の改善のポイントや動脈硬化罹病のリスクスコアーを世界で初めて示すことが出来るため、動脈硬化ガイドラインなどで引用でき、動脈硬化予防に大きく寄与することが可能な研究といえる。これらのエビデンスを用いて、頸動脈エコー検査を実施せずとも、健診や外来のデータを用いてプラーク進展の予測確率を簡便に掲載できることが可能となる。
|
