| Project/Area Number |
17K19881
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Health science and related fields
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| Research Institution | Tohoku University |
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Principal Investigator |
Dan Takashi 東北大学, 医学系研究科, 准教授 (00512451)
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| Project Period (FY) |
2017-06-30 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 老化制御 / PAI-1 / TNFα / LPS / SASP / 老化 / マクロファージ / TGFβ / 転写制御 / SASP(細胞老化関連分泌形質) / TGF-β1 / 発現制御 |
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| Outline of Final Research Achievements |
As a result of examining the influence of PAI-1 on the transcription of TNFα of SASP (cellular senescence related secretory trait), the new physiological action of PAI-1 which has not been reported so far has been reported that PAI-1 directly enhances macrophage cytokine expression I found it. This action is completely different from conventionally known fibrinolytic control.
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| Academic Significance and Societal Importance of the Research Achievements |
化合物（仮称CompoundX）がPAI-1で誘導されるTNFα産生を抑制することの発見は、新薬創製のシーズとなり、新しい機序の抗炎症剤や抗がん剤の研究開発につながる。
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