Proposal for new research design of anti-hypertensive foods

• Project/Area Number: 17K19912
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Research Field: Health science and related fields
• Research Institution: Kyushu University
• Principal Investigator: Matsui Toshiro 九州大学, 農学研究院, 教授 (20238942)
• Project Period (FY): 2017-06-30 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 高血圧 / レニン-アンジオテンシン系 / アンジオテンシン代謝物 / 代謝物動態 / 機能性食品 / ペプチド / アンジオテンシン / 食品機能 / 高血圧予防

Outline of Final Research Achievements

In this study, in order to evaluate the dynamics of circulatory renin-angiotensin peptides, an LC-IT-MS/MS method was developed and the blood samples from young and aging SHRs were measured. As the result of the experiment, Angiotensin II concentration was increased by in aging rats, suggesting the correlation between renin-angiotensin-related peptide dynamics and aging/hypertension.

Academic Significance and Societal Importance of the Research Achievements

なぜ高血圧は発症するのか、血圧代謝系をどのように制御すればよいのか、高血圧診断の指標はあるのか、の問いについて、本研究では血圧代謝系での降圧に関わるアンジオテンシン代謝物と昇圧に関わるアンジオテンシン代謝物を一斉に検出可能な分析法を設定し、血圧上昇との相関関係を解明することを目的とした。これにより、どのような代謝物を高血圧指標にできるか、さらには機能性食品世襲の有効性を血圧代謝系制御に基づき評価することができると期待される。

Research Products

• [Journal Article] Intestinal absorption of small peptides: a review (2019)
  • Author(s): Weilin Shen, Toshiro Matsui
  • Journal Title: International Journal of Food Science and Technology Volume: 54 Issue: 6 Pages: 1942-1948
  • DOI: 10.1111/ijfs.14048
  • Peer Reviewed / Open Access
• [Journal Article] Current understanding of bioaccessibility and bioavailability of food‐derived bioactive peptides (2019)
  • Author(s): Mine Yoshinori、Matsui Toshiro
  • Journal Title: International Journal of Food Science & Technology Volume: 54 Issue: 7 Pages: 2319-2320
  • DOI: 10.1111/ijfs.14164
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Current knowledge of intestinal absorption of bioactive peptides (2017)
  • Author(s): Shen Weilin、Matsui Toshiro
  • Journal Title: Food & Function Volume: 8 Issue: 12 Pages: 4306-4314
  • DOI: 10.1039/c7fo01185g
  • Peer Reviewed
• [Presentation] Absorption behavior of bioactive peptides across intestinal membrane (2019)
  • Author(s): 松井利郎
  • Organizer: 2nd International symposium on bioactive peptides
  • Int'l Joint Research / Invited
• [Presentation] Application of MALDI-MS imaging technique for intestinal absorption process of bioactive peptides (2019)
  • Author(s): 松井利郎
  • Organizer: ICoFF2019 (7th)/ISNFF2019 (12th)
  • Int'l Joint Research / Invited
• [Presentation] Absorption of Cblin oligopeptide across Caco-2 cell monolayers and rat intestinal membrnae (2019)
  • Author(s): Weilin Shen, Mitsuru Tanaka, Reiko Nakao, Takeshi Nikawa, Toshiro Matsui
  • Organizer: ICoFF2019 (7th)/ISNFF2019 (12th)
  • Int'l Joint Research
• [Presentation] Simultaneous detection of angiotensin metabolites in rat plasma using LC-MS/MS method (2018)
  • Author(s): 申 偉琳、田中 充、松井利郎
  • Organizer: 第72回日本栄養・食糧学会
• [Presentation] ペプチド、ポリフェノール代謝解析に関する分析化学の重要性 (2018)
  • Author(s): 松井利郎
  • Organizer: 第3回メタボローム解析シンポジウム
  • Invited
• [Presentation] Transport of oligopeptides across Caco-2 cell monolayers (2018)
  • Author(s): 松井利郎
  • Organizer: 11th ISNFF
  • Int'l Joint Research / Invited
• [Presentation] 食品由来オリゴペプチドの吸収性および血圧調節作用について (2017)
  • Author(s): 松井利郎
  • Organizer: 第5回国際食品由来ペプチド学術交流会議
  • Int'l Joint Research / Invited
• [Presentation] Effect of aging on vasorelaxation of small peptides on contracted rat aorta (2017)
  • Author(s): 松井利郎
  • Organizer: ISNFF2017
  • Int'l Joint Research / Invited
• [Presentation] ペプチド吸収に対する加齢の影響の解明 (2017)
  • Author(s): 申 偉琳、Vu Thi Hanh、松井 利郎
  • Organizer: 第71回日本栄養・食糧学会
• [Presentation] Absorption of peptides into rat blood: Effect of peptide-length and aging of rats on absorption (2017)
  • Author(s): 松井利郎
  • Organizer: 108th AOCS Annual Meeting & Expo
  • Int'l Joint Research
• [Presentation] Small peptides: Anti-hypertensive and vasorelaxation actions (2017)
  • Author(s): 松井利郎
  • Organizer: International Symposium on Bioactive Peptides
  • Int'l Joint Research / Invited
• [Remarks] 食品分析学HP
  • URL: http://www.agr.kyushu-u.ac.jp/biosci-biotech/bunseki/
• [Remarks] 食品分析学HP
  • URL: http://www.agr.kyushu-u.ac.jp/lab/foodanalysis/