Nutritional intervention for cancer sarcopenia

• Project/Area Number: 17K19923
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Research Field: Health science and related fields
• Research Institution: Nara Medical University
• Principal Investigator: Kuniyasu Hiroki 奈良県立医科大学, 医学部, 教授 (00253055)
• Co-Investigator(Kenkyū-buntansha): 谷 里奈 奈良県立医科大学, 医学部, 助教 (20783872) ; 大森 斉 奈良県立医科大学, 医学部, 研究員 (80213875)
• Project Period (FY): 2017-06-30 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: がん性悪液質 / がん性サルコペニア / 中鎖脂肪酸 / シスチン / プテロスチルベン / ベルベリン / 悪液質 / アミノ酸 / ビタミン / 骨格筋 / グルコース / ミトコンドリア / エネルギー代謝 / サルコペニア / 糖 / リハビリテーション

Outline of Final Research Achievements

When the effects of nutrients on cancer sarcopenia were examined, glucose (Glc) showed a strong muscle protective effect but promoted tumor growth. Medium-chain fatty acid (MCFA) showed a strong antitumor effect and a moderate muscle protective effect. When Glc and MCFA were used in combination, the tumor-growing effect was offset and a strong muscle-protecting effect was observed. Cystine/theanine and pterostilbene have moderate antitumor and muscular protective effects. The combined use of them with Glc and MCFA was considered to be effective in suppressing cancer sarcopenia.

Academic Significance and Societal Importance of the Research Achievements

本研究により明らかとなったがん性サルコペニアに有効性を示す栄養素を用いた栄養介入は、簡便で低価格なもので容易に臨床応用可能である。これらに、適切な運動介入を組み合わせることでより効果的ながん性サルコペニアに対する改善効果が得られることが期待される。このような、簡便な方法によるがん性サルコペニアの抑制は、がん患者の社会復帰を促進すると考えられる。

Research Products

• [Int'l Joint Research] 南通大学(中国)
• [Int'l Joint Research] Nantong University(中国)
• [Int'l Joint Research] 南通大学(中国)
• [Journal Article] Evaluation of cancer-derived myocardial impairments using a mouse model (2020)
  • Author(s): Miyagawa Yoshihiro、Nukaga Shota、Mori Takuya、Fujiwara-Tani Rina、Fujii Kiyomu、Mori Shiori、Goto Kei、Kishi Shingo、Sasaki Takamitsu、Nakashima Chie、Ohmori Hitoshi、Kawahara Isao、Luo Yi、Kuniyasu Hiroki
  • Journal Title: Oncotarget Volume: 11 Issue: 41 Pages: 3712-3722
  • DOI: 10.18632/oncotarget.27759
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Anti-stem cell property of pterostilbene in gastrointestinal cancer cells. (2020)
  • Author(s): Mori S, Kishi S, Honoki K, Fujiwara-Tani R, Moriguchi T, Sasaki T, Fujii K, Tsukamoto S, Fujii H, Kido A, Tanaka Y, Luo Y, Kuniyasu H.
  • Journal Title: Int J Mol Sci. Volume: 21 Issue: 24 Pages: 9347-9347
  • DOI: 10.3390/ijms21249347
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Combined administration of lauric acid and glucose improved cancer‐derived cardiac atrophy in a mouse cachexia model (2020)
  • Author(s): Nukaga Shota、Mori Takuya、Miyagawa Yoshihiro、Fujiwara‐Tani Rina、Sasaki Takamitsu、Fujii Kiyomu、Mori Shiori、Goto Kei、Kishi Shingo、Nakashima Chie、Ohmori Hitoshi、Kawahara Isao、Luo Yi、Kuniyasu Hiroki
  • Journal Title: Cancer Science Volume: 111 Issue: 12 Pages: 4605-4615
  • DOI: 10.1111/cas.14656
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Targeting claudin‐4 enhances chemosensitivity in breast cancer (2020)
  • Author(s): Luo Yi、Kishi Shingo、Sasaki Takamitsu、Ohmori Hitoshi、Fujiwara‐Tani Rina、Mori Shiori、Goto Kei、Nishiguchi Yukiko、Mori Takuya、Kawahara Isao、Kondoh Masuo、Kuniyasu Hiroki
  • Journal Title: Cancer Science Volume: 111 Issue: 5 Pages: 1840-1850
  • DOI: 10.1111/cas.14361
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Malic enzyme 1 is associated with tumor budding in oral squamous cell carcinomas. (2020)
  • Author(s): Nakashima C, Kirita T, Yamamoto K, Mori S, Luo Y, Sasaki T, Fujii K, Ohmori H, Kawahara I, Mori T, Goto K, Kishi S, Fujiwara-Tani R, Kuniyasu H
  • Journal Title: Int J Mol Sci Volume: 21 Issue: 19 Pages: 7149-7149
  • DOI: 10.3390/ijms21197149
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clostridium perfringens enterotoxin induced claudin-4 to activate YAP in oral squamous cell carcinomas. (2020)
  • Author(s): Nakashima C, Yamamoto K, Kishi S, Sasaki T, Ohmori H, Fujiwara-Tani R Mori S, Kawahara I, Nishiguchi Y, Mori T, Kondoh M, Luo Y, Kirita T, Kuniyasu H
  • Journal Title: Oncotarget Volume: 11 Issue: 4 Pages: 309-321
  • DOI: 10.18632/oncotarget.27424
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Role of Metastasis-Related Genes in Cisplatin Chemoresistance in Gastric Cancer (2019)
  • Author(s): Nishiguchi Yukiko、Oue Naohide、Fujiwara-Tani Rina、Sasaki Takamitsu、Ohmori Hitoshi、Kishi Shingo、Mori Shiori、Mori Takuya、Ikeda Naoya、Matsumoto Sohei、Wakatsuki Kohei、Luo Yi、Yasui Wataru、Sho Masayuki、Kuniyasu Hiroki
  • Journal Title: International Journal of Molecular Sciences Volume: 21 Issue: 1 Pages: 254-254
  • DOI: 10.3390/ijms21010254
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Magnetic Hyperthermia Using Self-Controlled Heating Elements Consisting of Fe-Al Milling Alloy Induces Cancer Cell Apoptosis while Preserving Skeletal Muscle (2019)
  • Author(s): Kawahara Isao、Goto Kei、Kodama Kenji、Luo Yi、Fujiwara-Tani Rina、Mori Takuya、Miyagawa Yoshihiro、Tanaka Hirokazu、Kodama Hiroyuki、Hosoito Nobuyoshi、Taniguchi Yukinori、Kuniyasu Hiroki
  • Journal Title: Pathobiology Volume: 86 Issue: 5-6 Pages: 254-262
  • DOI: 10.1159/000501524
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Evaluation of Parameters for Cancer-Induced Sarcopenia in Patients Autopsied after Death from Colorectal Cancer (2019)
  • Author(s): Ohmori Hitoshi、Kawahara Isao、Mori Takuya、Nukaga Shota、Luo Yi、Kishi Shingo、Fujiwara-Tani Rina?、Mori Shiori、Goto Kei、Sasaki Takamitsu、Kuniyasu Hiroki
  • Journal Title: Pathobiology Volume: 86 Issue: 5-6 Pages: 306-314
  • DOI: 10.1159/000503037
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Targeting claudin‐4 enhances chemosensitivity of pancreatic ductal carcinomas (2019)
  • Author(s): Sasaki Takamitsu、Fujiwara‐Tani Rina、Kishi Shingo、Mori Shiori、Luo Yi、Ohmori Hitoshi、Kawahara Isao、Goto Kei、Nishiguchi Yukiko、Mori Takuya、Sho Masayuki、Kondo Masuo、Kuniyasu Hiroki
  • Journal Title: Cancer Medicine Volume: 8 Issue: 15 Pages: 6700-6708
  • DOI: 10.1002/cam4.2547
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Giving combined medium‐chain fatty acids and glucose protects against cancer‐associated skeletal muscle atrophy (2019)
  • Author(s): Mori Takuya、Ohmori Hitoshi、Luo Yi、Mori Shiori、Miyagawa Yoshihiro、Nukaga Shota、Goto Kei、Fujiwara‐Tani Rina、Kishi Shingo、Sasaki Takamitsu、Fujii Kiyomu、Kawahara Isao、Kuniyasu Hiroki
  • Journal Title: Cancer Science Volume: 110 Issue: 10 Pages: 3391-3399
  • DOI: 10.1111/cas.14170
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Concurrent Expression of CD47 and CD44 in Colorectal Cancer Promotes Malignancy (2019)
  • Author(s): Fujiwara-Tani Rina、Sasaki Takamitsu、Ohmori Hitoshi、Luo Yi、Goto Kei、Nishiguchi Yukiko、Mori Shiori、Nakashima Chie、Mori Takuya、Miyagawa Yoshihiro、Kawahara Isao、Fujii Kiyomu、Kishi Shingo、Tatsumoto Naokuni、Kuniyasu Hiroki
  • Journal Title: Pathobiology Volume: 86 Issue: 4 Pages: 182-189
  • DOI: 10.1159/000496027
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Targeting claudin-4 enhances CDDP-chemosensitivity of gastric cancer (2019)
  • Author(s): Nishiguchi Y, Fujiwara-Tani R, Sasaki T, Luo Y, Ohmori H, Kishi S, Mori S, Goto K, Yasui W, Sho M*, Kuniyasu H
  • Journal Title: Oncotarget Volume: 10 Issue: 22 Pages: 2189-2202
  • DOI: 10.18632/oncotarget.26758
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Concurrent expression of CD47 and CD44 in colorectal cancer promotes malignancy (2019)
  • Author(s): Fujiwara-Tani R, Sasaki T, Ohmori H, Luo Y, Goto K, Nishiguchi Y, Mori S, Nakashima C, Mori T, Miyagawa Y, Kawahara I, Fujii K, Kishi S, Tatsumoto N, Kuniyasu H
  • Journal Title: Pathobiology Volume: in press
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Magnetic hyperthermia using self-controlled heating elements consisting of Fe-Al milling alloy induces cancer cell apoptosis while preserving skeletal muscle. (2019)
  • Author(s): Kawahara I, Goto K, Kodama K, Luo Y, Fujiwara-Tani R, Mori T, Miyagawa Y, Tanaka H, Kodama H, Hirayama A, Hosoito N, Taniguchi Y, Miki Y, Kuniyasu H
  • Journal Title: Pathobiology Volume: in press
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Intermittent calorie restriction enhances epithelial- mesenchymal transition through alteration of energy metabolism in a mouse tumor model. (2018)
  • Author(s): Kusuoka O, Fujiwara-Tani R, Nakashima C, Fujii K, Ohmori H, Mori T, Kishi S, Miyagawa Y, Goto K, Kawahara I, Kuniyasu H
  • Journal Title: Int J Oncol Volume: 52 Pages: 413-423
  • DOI: 10.3892/ijo.2017.4229
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expression of cytosolic malic enzyme (ME1) is associated with disease progression in human oral squamous cell carcinoma (2018)
  • Author(s): Nakashima C, Yamamoto K, Fujiwara-Tani R, Luo Y, Matsushima S, Fujii K, Ohmori H, Sasahira T, Sasaki T, Kitadai Y, Kirita T, Kuniyasu H
  • Journal Title: Cancer Sci Volume: in press Issue: 6 Pages: 2036-2045
  • DOI: 10.1111/cas.13594
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pancreatic adenocarcinoma upregulated factor has oncogenic functions in oral squamous cell carcinoma (2018)
  • Author(s): Sasahira T, Kurihara M, Nishiguchi Y, Nakashima C, Kirita T, Kuniyasu H.
  • Journal Title: Histopathol Volume: 70 Pages: 539-548
  • DOI: 10.1016/j.ejps.2018.02.016
  • Peer Reviewed
• [Journal Article] Pro-metastatic signaling of elaidic acid, a trans fatty acid, is associated with lipid rafts. (2018)
  • Author(s): Kishi S, Fujiwara-Tani R, Luo Y, Kawahara I, Goto K, Fujii K, Ohmori H, Nakashima C, Sasaki T, Kuniyasu H
  • Journal Title: Oncol Lett Volume: 15 Pages: 4423-4426
  • DOI: 10.3892/ol.2018.7817
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expression of the long-chain fatty acid receptor GPR40 was associated with cancer progression in colorectal cancer. (2018)
  • Author(s): Nakashima C, Kishi S, Fujiwara-Tani R, Luo Y, Kawahara I, Goto K, Fujii K, Ohmori H, Kuniyasu H*
  • Journal Title: Oncol Lett Volume: 15 Pages: 8641-8646
  • DOI: 10.3892/ol.2018.8383
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Multifarious Functions of Pyruvate Kinase M2 in Oral Cancer Cells (2018)
  • Author(s): Kurihara-Shimomura M, Sasahira T, Nakashima C, Kuniyasu H, Shimomura H, Kirita T
  • Journal Title: Int J Mol Sci Volume: 19 Issue: 10 Pages: 10-10
  • DOI: 10.3390/ijms19102907
  • Peer Reviewed / Open Access
• [Journal Article] Significance of intranuclear angiotensin-II type 2 receptor in oral squamous cell carcinoma (2018)
  • Author(s): Matsushima-Otsuka S, Fujiwara-Tani R, Sasaki T, Ohmori H Nakashima C, Kishi S, Nishiguchi Y, Fujii K, Luo Y, Kuniyasu H
  • Journal Title: Oncotarget 9(93): , 2018 Volume: 9 Issue: 93 Pages: 36561-36574
  • DOI: 10.18632/oncotarget.26337
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Intake of medium-chain fatty acids induces oxidative stress and to atrophy the myocardium (2018)
  • Author(s): Miyagawa Y, Mori T, Goto K, Fujiwara-Tani R, Kishi S, Sasaki T, Fujii K, Ohmori H, Kawahara I, Kuniyasu H
  • Journal Title: Lipids in Health and Disease Volume: 17 Issue: 1 Pages: 258-258
  • DOI: 10.1186/s12944-018-0908-0
  • Peer Reviewed / Open Access
• [Journal Article] Anti-claudin-4 extracellular domain antibody enhances the antitumoral effects of chemotherapeutic and antibody drugs in colorectal cancer (2018)
  • Author(s): Fujiwara-Tani R, Sasaki T, Luo Y, Ohmori H, Nishiguchi Y, Kishi S, Mori S, Goto K, Kondoh M, Kuniyasu H*
  • Journal Title: Oncotarget Volume: 9 Issue: 100 Pages: 37367-37378
  • DOI: 10.18632/oncotarget.26427
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pro-metastatic intracellular signaling of elaidic acid, a trans fatty acid. (2017)
  • Author(s): Fujii K, Luo Y, Nishiguchi Y, Fujiwara R, Kishi S, He S, Yang S, Sasaki T, Ohmori H, Kuniyasu H
  • Journal Title: Int J Oncol Volume: 50 Issue: 1 Pages: 85-92
  • DOI: 10.3892/ijo.2016.3797
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Elaidic acid, a trans fatty acid, enhances the metastasis of colorectal cancer cells (2017)
  • Author(s): Ohmori H, Fujii K, Kadochi Y, Mori S, Nishiguchi Y, Fujiwara R, Kishi S, Sasaki T, Kuniyasu H
  • Journal Title: Pathobiol Volume: in press Issue: 3 Pages: 144-151
  • DOI: 10.1159/000449205
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Fatty acids inhibit anti-cancer effect of 5-fluorouracil in mouse cancer cell lines. (2017)
  • Author(s): Tanabe E, Kitayoshi M, Fujii K, Ohmori H, Luo Y, Fujiwara R, Kadochi Y, Mori S, Kuniyasu H*.
  • Journal Title: Oncol Lett Volume: 14 Issue: 1 Pages: 681-686
  • DOI: 10.3892/ol.2017.6190
  • Peer Reviewed / Open Access
• [Journal Article] Proton pump inhibitor induces-collagen expression in colonocytes is associated with collagenous colitis. (2017)
  • Author(s): Mori S, Kadochi Y, Luo Y, Fujiwara-Tani R, Nishiguchi Y, Kishi S, Fujii K, Ohmori H, Kuniyasu H
  • Journal Title: World J Gastroentrol Volume: 23 Issue: 9 Pages: 1586-1593
  • DOI: 10.3748/wjg.v23.i9.1586
  • Peer Reviewed / Open Access
• [Journal Article] Remodeling of energy metabolism by a ketone body and medium-chain fatty acid suppressed proliferation of CT26 mouse colon cancer cells. (2017)
  • Author(s): Kadochi Y, Mori S, Fujiwara-Tani R, Luo Y, Nishiguchi Y, Kishi S, Fujii K, Ohmori H, Kuniyasu H
  • Journal Title: Oncol Lett Volume: 14 Issue: 1 Pages: 673-680
  • DOI: 10.3892/ol.2017.6195
  • Peer Reviewed / Open Access
• [Journal Article] Fatty acids induce stemness in the stromal cells of a CT26 mouse tumor model (2017)
  • Author(s): Kawahara I, Mori T, Goto K, Fujii K, Ohmori H, Fujiwara-Tani R, Kuniyasu H
  • Journal Title: Pathobiol Volume: in press Issue: 5 Pages: 237-242
  • DOI: 10.1159/000471854
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Overexpression of PCDHB9 promotes peritoneal metastasis and correlates with poor prognosis in patients with gastric cancer. (2017)
  • Author(s): Mukai S, Oue N, Oshima T, Imai T, Sekino Y, Honma R, Sakamoto N, Sentani K, Kuniyasu H, Egi H, Tanabe K, Yoshida K, Ohdan H, Yasui W.
  • Journal Title: J Pathol Volume: 243 Issue: 1 Pages: 100-110
  • DOI: 10.1002/path.4931
  • Peer Reviewed / Open Access
• [Presentation] 網羅的遺伝子発現解析による胃がんの発生・進展の理解 (2020)
  • Author(s): 大上直秀，山本悠司, 浅井竜一, 國安弘基, 仙谷和弘, 坂本直也, 大段秀樹, 吉田和弘, 安井弥
  • Organizer: 第109回日本病理学会総会
  • Invited
• [Presentation] 糖質と中鎖脂肪酸の併用経口投与は悪液質における癌関連骨格筋萎縮を抑制する (2020)
  • Author(s): 森 拓也、 大森 斉、川原 勲、宮川良博、後藤 桂、額賀翔太、森 汐莉、岸 真五、谷 里奈、國安弘基
  • Organizer: 第109回日本病理学会総会
• [Presentation] アミノ酸シスチン・テアニン摂取ががん悪液質マウスの骨格筋と腫瘍増殖に与える効果 (2020)
  • Author(s): 川原 勲、大森 斉、森 拓也、宮川良博、後藤 桂、額賀翔太、森 汐莉、岸 真五、谷 里奈、國安弘基
  • Organizer: 第109回日本病理学会総会
• [Presentation] Parameters for cancer-induced sarcopenia in patients autopsied after death from colorectal cancer (2020)
  • Author(s): Mori T, Ohmori H, Luo Y, Kawahara I, Nukaga S, Miyagawa Y, Goto K, Kuniyasu H
  • Organizer: 79th Annual Meeting of Japanese Association for Cancer
• [Presentation] Effect of lauric acid intake on skeletal muscle atrophy caused by 5-FU treatment in CT26 colon cancer mouse model. (2020)
  • Author(s): Kawahara I, Mori T, Luo Y, Nukaga S, Miyagawa Y, Goto K, Ohmori H, Kuniyasu H
  • Organizer: 79th Annual Meeting of Japanese Association for Cancer
• [Presentation] Dual inhibition of distinct metabolic features targets osteosarcoma stem cells (2019)
  • Author(s): Kishi S, Honoki K, Tsukamoto S, Fujii H, Kondo Y, Tanaka Y, Kuniyasu H
  • Organizer: American Association for Cancer Research Annual Meeting 2019
  • Int'l Joint Research
• [Presentation] Proof of concept for claudin-2-directed cancer therapy by using a monoclonal antibody that recognizes the extracellular loop domain of claudin-2 (2019)
  • Author(s): Hashimoto Y, Hata T, Tada M, Iida M, Watari A, Okada Y, Doi T, Kuniyasu H, Yagi K, Tachibana K, Kondoh M
  • Organizer: 2019 Controlled Release Society Annual Meeting & Exposition
  • Int'l Joint Research
• [Presentation] 中鎖脂肪酸が骨格筋組織と骨格筋細胞代謝に及ぼす影響 (2019)
  • Author(s): 森 拓也、宮川良博、川原 勲、後藤 桂、森 汐莉、岸 真五、谷 里奈、國安弘基
  • Organizer: 第108回日本病理学会総会
• [Presentation] がん悪液質における骨格筋萎縮は腫瘍成長に伴い放出されるHMGB1の影響を受ける (2019)
  • Author(s): 森 拓也、大森 斉、川原 勲、宮川良博、額賀翔太、後藤 桂、羅 奕、國安弘基
  • Organizer: 第4回日本がんサポーティブケア学会学術集会
• [Presentation] がん悪液質における心筋ミトコンドリア機能障害に対する中鎖脂肪酸の効果 (2019)
  • Author(s): 額賀翔太、大森 斉、森 拓也、宮川良博、後藤 桂、川原 勲、國安弘基
  • Organizer: 第4回日本がんサポーティブケア学会学術集会
• [Presentation] Effects of nutritional intervention on cancer-related skeletal muscle atrophy (2019)
  • Author(s): Kawahara I, Ohmori H, Mori T, Miyagawa Y, Nukaga S, Goto K, Mori S, Kishi S, Fujiwara-Tani R, Kuniyasu H
  • Organizer: 78th Annual Meeting of Japanese Association for Cancer
• [Presentation] Role of HMGB1 in skeletal muscle atrophy from cancer cachexia (2019)
  • Author(s): Mori T, Ohmori H, Kawahara I, Miyagawa Y, Nukaga S, Goto K, Mori S, Kishi S, Fujiwara-Tani R, Kuniyasu H
  • Organizer: 78th Annual Meeting of Japanese Association for Cancer, Kyoto, 2019.926-28
• [Presentation] Lauric acid, a medium-chain fatty acid protects myocardial mitochondria from dysfunction in cancer cachexia (2019)
  • Author(s): Nukaga S, Ohmori H, Mori T, Miyagawa Y, Goto K, Kawahara I, Fujiwara-Tani R, Kishi S, Mori S, Kuniyasu H
  • Organizer: 78th Annual Meeting of Japanese Association for Cancer
• [Presentation] Cancer cachexia induces myocardial atrophy by mitochondrial dysfunction producing oxidative stress (2019)
  • Author(s): Miyagawa Y, Ohmori H, Mori T, Nukaga S, Kawahara I, Goto K, Mori S, Kishi S, Kuniyasu H
  • Organizer: 78th Annual Meeting of Japanese Association for Cancer
• [Presentation] ミトコンドリア代謝を標的とした肉腫治療の可能性 (2018)
  • Author(s): 岸 真五、朴木寛也、城戸顕、辻内俊文、田中康仁、國安弘基
  • Organizer: 第3回日本整形外科学会基礎学術集会
  • Invited
• [Presentation] がんのエネルギー代謝―がん悪性形質との関連 (2018)
  • Author(s): 國安弘基、森汐莉、谷里奈、岸真吾、西口由希子、森拓也、宮川良博、後藤桂、川原勲、大森斉
  • Organizer: 第29回日本消化器癌発生学会
  • Invited
• [Presentation] 担癌マウスにおける糖摂取の癌増殖および筋萎縮におよぼす影響 (2017)
  • Author(s): 森 拓也、川原 勲、後藤 桂 、宮川良博、谷 里奈、國安弘基
  • Organizer: 第106回日本病理学会総会、東京都
• [Presentation] 腹膜播種モデルおけるラウリン酸の経口摂取が抗腫瘍と骨格筋萎縮に及ぼす影響 (2017)
  • Author(s): 森 拓也、川原 勲、後藤 桂、宮川良博、門地優衣、國安弘基
  • Organizer: 第106回日本病理学会総会、東京都
• [Presentation] カヘキシア誘発マウスにおける中鎖脂肪酸経口摂取が腫瘍重量と骨格筋量に及ぼす影響 (2017)
  • Author(s): 森 拓也、宮川良博、川原 勲、後藤 桂、國安弘基
  • Organizer: 第52回日本理学療法学術大会、千葉市
• [Presentation] 2型糖尿病患者における表面筋電図を用いた骨格筋変性の評価 (2017)
  • Author(s): 宮川良博、額賀翔太、森 拓也、井上純爾、杉岡達也、後藤 桂、川原 勲
  • Organizer: 第52回日本理学療法学術大会、千葉市
• [Presentation] The effects of food nutrition ingredients against cancer sarcopenia (2017)
  • Author(s): Mori T, Miyagawa Y, Kawahara I, Goto K, Kishi S, Fujiwara-Tani R, Kuniyasu H
  • Organizer: 76th Annual Meeting of Japanese Association for Cancer, Yokohama
• [Presentation] The effects of food nutrition ingredients against cancer sarcopenia (2017)
  • Author(s): Miyagawa Y, Mori T, Kawahara I, Goto K, Kishi S, Fujiwara-Tani R, Kuniyasu H
  • Organizer: 76th Annual Meeting of Japanese Association for Cancer, Yokohama
• [Presentation] Fatty acids induce stemness in the stromal cells of a CT26 mouse tumor model (2017)
  • Author(s): Kawahara I, Mori T, Goto K, Miyagawa Y, Mori S, Kishi S, Fujiwara-Tani R, Kuniyasu H
  • Organizer: 76th Annual Meeting of Japanese Association for Cancer, Yokohama
• [Presentation] Significance of magnetic hyperthermia for induction of cancer cell apoptosis and preservation of skeletal muscle (2017)
  • Author(s): Goto K, Kawahara I, Mori T, Miyagawa Y, Mori S, Kishi S, Fujiwara-Tani R, Kuniyasu H
  • Organizer: 76th Annual Meeting of Japanese Association for Cancer, Yokohama
• [Presentation] Fatty acids induce stemness in the stromal cells of a CT26 mouse tumor model (2017)
  • Author(s): Kawahara I, Mori T, Goto K, Miyagawa Y, Mori S, Kishi S, Fujiwara-Tani R, Kuniyasu H
  • Organizer: 第4回日本サルコペニア・フレイル学会、京都市
• [Presentation] マウスカへキシア・モデルにおける 5-FU とラウリン酸の併用が腫瘍増殖と骨格筋萎 縮に与える影響 (2017)
  • Author(s): 森 拓也、川原 勲、後藤 桂、宮川良博、國安弘基
  • Organizer: 第2回日本がんサポーティブケア学会学術集会、さいたま市
• [Presentation] カヘキシア誘発マウスモデルを用いたラウリン酸経口摂取が腫瘍増殖と骨格筋萎縮に およぼす影響 (2017)
  • Author(s): 宮川良博、森 拓也、川原 勲、後藤 桂、國安弘基
  • Organizer: 第2回日本がんサポーティブケア学会学術集会、さいたま市
• [Presentation] がんに対する磁気温熱療法の骨格筋への影響 (2017)
  • Author(s): 川原 勲、森 拓也、後藤 桂、宮川良博、國安弘基
  • Organizer: 第2回日本がんサポーティブケア学会学術集会、さいたま市
• [Presentation] マウス CT26 皮下腫瘍モデルを用いた糖負荷が腫瘍増殖と骨格筋萎縮におよぼす影響 (2017)
  • Author(s): 後藤 桂、森 拓也、川原 勲、宮川良博、國安弘基
  • Organizer: 第2回日本がんサポーティブケア学会学術集会、さいたま市
• [Remarks] 奈良県立医科大学分子病理学HP
  • URL: http://www.naramed-u.ac.jp/~molepath/